Ageratina para Temblores (Trembles)
Ageratina altissima — 5 estudios científicos revisados
Strong¿Sirve Ageratina para temblores (trembles)?
La ingestión de compuestos como la tremetona provoca una neurotoxicidad y miotoxicidad que se manifiesta como sacudidas musculares involuntarias.
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Ageratina y temblores (trembles):
Toxicity of white snakeroot (Ageratina altissima) and chemical extracts of white snakeroot in goats.
White snakeroot (Ageratina altissima) is a sporadically toxic plant that causes trembles in livestock and milk sickness in humans that drink tainted milk. The putative toxin in white snakeroot is tremetone and possibly other benzofuran ketones, even though it has not been demonstrated in vivo. Toxic white snakeroot was dosed to goats, and they developed clinical signs of poisoning, exercise intolerance, significant increases in serum enzyme activities, and histological changes. Tremetone and the other benzofuran ketones were extracted with hexane; the extracts and residues were analyzed for tr
PubMed: 25641641Effect of grinding and long-term storage on the toxicity of white snakeroot (Ageratina altissima) in goats.
White snakeroot (Ageratina altissima) contains the putative toxin tremetone and can produce a disease called "trembles" or "milk sickness". However the toxicity of tremetone has not been demonstrated in vivo. It has been reported that the plant is less toxic after drying and grinding. The objectives of these studies were to determine: 1) the toxic effect of grinding white snakeroot 4 months prior to dosing and, 2) the toxic effect of storing white snakeroot at ambient temperature for 5 years. Dried white snakeroot, ground 1 day, 1 month, and 4 months prior to dosing, was orally gavaged to goat
PubMed: 29702438Tremetone and structurally related compounds in white snakeroot ( Ageratina altissima ): a plant associated with trembles and milk sickness.
Ingestion of white snakeroot ( Ageratina altissima ) can cause trembles in livestock and milk sickness in humans. The toxicity has been associated with tremetol, a relatively crude, multicomponent lipophilic extract of the plant. In this study, 11 different compounds were isolated from white snakeroot-derived lipophilic extracts from 18 collections. Six of the isolated compounds have not been previously reported to be found in white snakeroot. High-performance liquid chromatography (HPLC) analysis indicated that there are three different chemotypes of white snakeroot from the plant samples ana
PubMed: 20681643Quantitative method for the measurement of three benzofuran ketones in rayless goldenrod (Isocoma pluriflora) and white snakeroot (Ageratina altissima) by high-performance liquid chromatography (HPLC).
White snakeroot ( Ageratina altissima ) and rayless goldenrod ( Isocoma pluriflora ) can cause "trembles" and "milk sickness" in livestock and humans, respectively. Tremetol, a complex mixture of sterols and derivatives of methyl ketone benzofuran has been extracted from white snakeroot and rayless goldenrod and is reported to be the toxic substance in plant material. In this study, the three major benzofuran ketones, tremetone, dehydrotremetone, and 3-oxyangeloyl-tremetone, were isolated from rayless goldenrod. Using these compounds as standards, a quantitative high-performance liquid chromat
PubMed: 19480385Evaluation of drying methods and toxicity of rayless goldenrod ( Isocoma pluriflora ) and white snakeroot ( Ageratina altissima ) in goats.
White snakeroot and rayless goldenrod cause "trembles" and "milk sickness" in livestock and humans, respectively. The toxin in white snakeroot and rayless goldenrod was identified in 1927 and 1930, respectively, as tremetol. It was reported that the toxin in white snakeroot disappears as it is dried and that completely dried plants were incapable of producing trembles or milk sickness. Conversely, it has been reported that the rayless goldenrod toxin was not destroyed by drying and that the plant is toxic either fresh or dry. In this study the concentrations of tremetone, dehydrotremetone, and
PubMed: 22541005Seguridad y Precauciones
La seguridad en el uso de Ageratina altissima es extremadamente crítica debido a su perfil de toxicidad sistémica y miotóxica. No existe una dosis segura establecida para el consumo humano, ya que la planta es reconocida por causar la enfermedad conocida como 'milk sickness' (enfermedad de la leche) a través de la ingesta de productos lácteos contaminados. (1) En el caso de embarazo y lactancia, el riesgo es severo. Debido a que los compuestos tóxicos como la tremetona son lipofílicos (tienen afinidad por las grasas), pueden atravesar fácilmente la barrera placentaria y almacenarse en los tejidos grasos de la madre, afectando el desarrollo fetal. En la lactancia, existe un riesgo directo de transferencia de toxinas al lactante a través de la leche materna, lo cual puede provocar cuadros de intoxicación aguda en el bebé. (2) Para niños menores de 12 años, la toxicidad es potencialmente letal debido a su menor masa corporal; la exposición accidental puede resultar en cuadros de debilidad muscular severa y excitación neurológica.
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