Aguaymanto para Inflamación sistémica
Physalis peruviana — 18 estudios científicos revisados
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Los withanólidos actúan reduciendo la actividad de mediadores proinflamatorios en el organismo.
Compuestos activos involucrados: withanólidos, witaferinas, carotenoides, ácido ascórbico, Alcaloides, Flavonoides, Saponinas, Terpeno, Terpenos, Vitamina, Vitamina c, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Aguaymanto y inflamación sistémica:
Withanolide glycosides from Physalis volubilis.
The study of the acetone and methanol extracts of the stems, leaves, and flowers of Physalis volubilis led to obtain four withanolide glycosides (4, 6, 10, and 14). Compounds 1-3, 13, 15, and a sterol glycoside were also isolated. The structures were established by analysis of spectroscopic and spectrometric data, and by chemical transformations. Nine of the obtained compounds (2, 3, 6, 7, 10, 11, and 13-15) were evaluated for their qualitative antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Compound 2
PubMed: 39938657A comprehensive quality evaluation method of different medicinal parts of Physalis Calyx seu Fructus by fingerprints, chemometrics, antioxidant activity, network pharmacology and molecular docking.
Physalis Calyx seu Fructus (PCF) is a herb widely used in China for its function of clearing heat and detoxifying, benefitting the pharynx and reducing phlegm, both in health care and in tea drinking. However, the quality of its fruit and calyx is uneven and the storage period is short. Therefore, it is crucial to develop other parts of PCF with longer storage periods and obvious medicinal effects. Firstly, high-performance liquid chromatography was used to develop the fingerprint of different parts of PCF, and various chemometric analyses were conducted to screen out chemical markers. The cal
PubMed: 37406673Efficient and cost-effective shoot regeneration in Aguaymanto (Physalis peruviana L.) using meta-Topolin and 6-benzylaminopurine combinations.
Physalis peruviana L. (known as aguaymanto or goldenberry) is a high-value Andean fruit crop with growing international demand due to its nutritional and nutraceutical properties. However, the development of advanced biotechnological tools for this species has been limited by the lack of efficient and reproducible in vitro regeneration protocols. Existing systems rely primarily on the use of zeatin, a highly effective but expensive cytokinin, which restricts their applicability in resource-limited laboratories. In this study, the synergistic effect of 6-benzylaminopurine (BAP) and meta-topolin
PubMed: 41386863Bioactive Compounds from Plants Used in Peruvian Traditional Medicine.
It is estimated that there are as many as 1400 plant species currently used in traditional Peruvian medicine; however, only a few have undergone scientific investigation. In this paper, we make a review of the botanical, chemical, pharmacological and clinical propierties of the most investigated Peruvian medicinal plants. The plant species selected for this review are: Smallanthus sonchifolius (yacon), Croton lechleri (sangre de grado), Uncaria tomentosa/U. guianensis (uña de gato), Lepidium meyenii (maca), Physalis peruviana (aguaymanto), Minthostachys mollis (muña), Notholaena nivea (cuti-cu
PubMed: 27169179Biologically active withanolides from
CONTEXT: OBJECTIVE: To study the chemical composition and potential medicinal properties of Poha. MATERIALS AND METHODS: The fresh fruits and aerial parts of Poha were extracted. The isolation of extract yields a novel withanolide (physaperuvin K; RESULTS: The structure of CONCLUSIONS: These findings enhance our understanding of Poha's constituents and potential medicinal properties. One of the most bioactive compounds identified in this study, physaperuvin K, is found in edible fruit.
PubMed: 40285658Seguridad y Precauciones
En el ámbito de la seguridad clínica, el uso de Physalis peruviana durante el embarazo y la lactancia debe abordarse con extrema cautela debido a la absoluta carencia de ensayos clínicos controlados en humanos que garanticen la inocuidad de la planta en estas etapas. La presencia de compuestos bioactivos complejos, como los withanólidos, sugiere un riesgo potencial de transferencia transplacentaria, lo que podría comprometer el desarrollo embrionario o fetal, aunque la evidencia científica actual es insuficiente para confirmar este mecanismo. En la lactancia, la farmacocinética de las witaferinas y otros metabolitos en la leche materna es completamente desconocida, por lo que se desaconseja su consumo para prevenir la exposición involuntaria del lactante. Para la población pediátrica, específicamente niños menores de 12 años, el uso de extractos concentrados está contraindicado debido a la inmadurez de las vías de biotransformación hepática y la sensibilidad de los sistemas de filtración renal en desarrollo. Respecto a las interacciones farmacológicas, la administración conjunta con warfarina representa un riesgo significativo, ya que los componentes de la planta podrían alterar la cascada de coagulación, incrementando el riesgo de hemorragias. La interacción con la metformina es crítica, dado que el potencial hipoglucemiante de la planta puede potenciar el efecto del fármaco, provocando episodios de hipoglucemia severa.
Otras plantas estudiadas para Inflamación sistémica
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