Angelica para Fibrosis hepática
Angelica dahurica — 5 estudios científicos revisados
Preliminary¿Sirve Angelica para fibrosis hepática?
Componentes como el bergapteno han mostrado potencial para mitigar la fibrosis mediante la activación de la vía de señalización FXR.
Compuestos activos involucrados: Bergaptenina, Cumarinas, Flavonoides, Furanocumarina, Imperatorina, Polisacárido, Terpenos, Beta-sitosterol, Compuestos fenólicos, Sitosterol
Evidencia Científica
Los siguientes estudios han investigado la relación entre Angelica y fibrosis hepática:
Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma.
Osteosarcoma (OS) is a malignant bone tumor of mesenchymal origin. Angelica dahurica is a typical traditional Chinese herb. Angelica dahurica is used in the treatment of a variety of tumors. However, the studies of Angelica dahurica for OS have not been reported. To investigate Angelica dahurica's potential mechanism of action in the treatment of OS, we used network pharmacology and molecular docking methods in this study.
PubMed: 36343039Effect of Angelica dahurica, Angelica dahurica polysaccharides, and imperatorin on free and bound heterocyclic amine generation in roasted beef patties and release profiles of bound heterocyclic amines during in vitro digestion.
This study explored the suppressive activity of Angelica dahurica (AD), AD polysaccharides, and imperatorin on free and bound heterocyclic amine (HA) formation in roast beef patties and release profiles of bound HAs during in vitro digestion. The suppressive effects and potential mechanisms associated with free radical quenching were explored using UPLC-MS/MS, multivariate statistical analysis, and electron paramagnetic resonance (EPR). AD (0.5%, 1.0%, and 1.5%) and imperatorin (0.005%, 0.010%, and 0.015%) showed a dose-dependent inhibition for both free and bound HAs, with AD polysaccharides
PubMed: 38129016Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway.
Angelica dahurica (A. dahurica) has a wide range of pharmacological effects, including analgesic, anti-inflammatory and hepatoprotective effects. In this study, we investigated the effect of A. dahurica extract (AD) and its effective component bergapten (BG) on hepatic fibrosis and potential mechanisms. Hepatic fibrosis was induced by intraperitoneal injection with carbon tetrachloride (CCl
PubMed: 38334900Metabolomics analysis reveals metabolite changes during freeze-drying and oven-drying of Angelica dahurica.
Angelica dahurica (Angelica dahurica Fisch. ex Hoffm.) is widely used as a traditional Chinese medicine and the secondary metabolites have significant pharmacological activities. Drying has been shown to be a key factor affecting the coumarin content of Angelica dahurica. However, the underlying mechanism of metabolism is unclear. This study sought to determine the key differential metabolites and metabolic pathways related to this phenomenon.
PubMed: 37055447Anti-inflammatory Study on the Constituents of Angelica sinensis (Oliv.) Diels, Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav., Angelica pubescence Maxim and Foeniculum vulgare Mill. Essential Oils.
Umbelliferae plants, which are widely used as traditional Chinese medicine because of their characteristics of relieving rheumatism, alleviating fever, circulating blood and easing pain. This experimental study was based on ear edema model caused by 12-O-tetracycline-propylphenol-13-acetic acid (TPA) in mice and compared with the Ibuprofen (Ib) group. Gas chromatography-mass spectrometry (GC-MS) was used to analyse the composition of the essential oils from the four studied Umbelliferae plants (Angelica sinensis (Oliv.) Diels, A. dahurica (Hoffm.) Benth. & Hook.f.
PubMed: 35793972Seguridad y Precauciones
El uso de Angelica dahurica conlleva riesgos significativos que deben ser evaluados con rigor clínico. En el caso de mujeres embarazadas y en periodo de lactancia, no existe evidencia científica suficiente que garantice la seguridad del consumo de sus compuestos activos, como las cumarinas (por ejemplo, la bergapteno o la imperatorina). Debido a que estas sustancias pueden atravesar la barrera placentaria o ser excretadas a través de la leche materna, existe el riesgo teórico de interferencia con el desarrollo fetal o neonatal. No se recomienda su uso en estas etapas debido a la falta de perfiles toxicológicos establecidos para el desarrollo embrionario. Para niños menores de 12 años, el uso de Angelica dahurica está estrictamente contraindicado. Los sistemas metabólicos y enzimáticos de los infantes son inmaduros, lo que podría resultar en una toxicidad inesperada o en una respuesta farmacológica desproporcionada.
Otras plantas estudiadas para Fibrosis hepática
Perfil completo: Ver todos los usos y evidencia de Angelica →