Aristolochia para Carcinogénesis (formación de tumores)
Aristolochia manshuriensis — 5 estudios científicos revisados
Strong¿Sirve Aristolochia para carcinogénesis (formación de tumores)?
La exposición a los componentes de la planta puede inducir mutaciones genéticas que resultan en tumores en órganos como la vejiga, el estómago y el riñón.
Compuestos activos involucrados: Alcaloides, Flavonoides, Saponinas, Terpenos, ácido, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Aristolochia y carcinogénesis (formación de tumores):
Aristolochia manshuriensis Kom inhibits adipocyte differentiation by regulation of ERK1/2 and Akt pathway.
Aristolochia manshuriensis Kom (AMK) is a traditional medicinal herb used for the treatment of arthritis, rheumatism, hepatitis, and anti-obesity. Because of nephrotoxicity and carcinogenicity of AMK, there are no pharmacological reports on anti-obesity potential of AMK. Here, we showed AMK has an inhibitory effect on adipocyte differentiation of 3T3-L1 cells along with significantly decrease in the lipid accumulation by downregulating several adipocyte-specific transcription factors including peroxisome proliferation-activity receptor γ (PPAR-γ), CCAAT/enhancer binding protein α (C/EBP-α) and
PubMed: 23166699Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse.
Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways medicinally, including via ingestion of low doses for short periods of time. Non-alcoholic steatohepatitis (NASH) induced the hepatocyte injury and inflammation. The protective effects of AMK against NASH are unclear; therefore, in this study, the protective effects of AMK ethyl acetate extract were investigated in a high-fat diet (HFD)-induced NASH model. We found decreased hepatic steatosi
PubMed: 26726030Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs.
ETHNOPHARMACOLOGICAL RELEVANCE: Aristolochia manshuriensis Kom (AMK), belonging to the Aristolochia family, is traditionally used in China to remove heart fire, promote dieresis, restore menstruation, and enhance milk secretion. The active constitutes of AMK are aristolochic acids (AAs, I and II) that are reported to cause serious side effects including nephrotoxicity and carcinogenicity. AIM OF THE STUDY: The tumorigenic role of AMK is far to be understood. We analyzed the toxicity reactions after long-term exposure of AMK in rats. MATERIALS AND METHODS: Sprague-Dawley rats underwent gavage w
PubMed: 30008395Rapid Identification of Officinal Akebiae Caulis and Its Toxic Adulterant Aristolochiae Manshuriensis Caulis (Aristolochia manshuriensis) by Loop-Mediated Isothermal Amplification.
Mu-tong (Akebiae Caulis) is a traditional Chinese medicine commonly used as a diuretic and antiphlogistic. A common adulterant of Mu-tong is Guan-mu-tong (Aristolochiae Manshuriensis Caulis), which is derived from the stem of Aristolochia manshuriensis Komarov, and contains carcinogenic aristolochic acids. We used an alternative technique, loop-mediated isothermal amplification (LAMP), to differentiate Mu-tong from Guan-mu-tong because LAMP is quick, highly sensitive, and specific. We designed a set of four common primers (G-F3, G-B3, G-FIP, and G-BIP) and a loop primer (G-LB) for LAMP based o
PubMed: 27379153Possible role of mitochondrial injury in Caulis Aristolochia manshuriensis-induced chronic aristolochic acid nephropathy.
CONTEXT: The proximal tubular epithelial cells (PTECs) are the primary target of aristolochic acids and especially vulnerable to mitochondrial injury from insults of toxic xenobiotics. OBJECTIVES: This study aimed to investigate the possible role of mitochondrial injury in Caulis Aristolochia manshuriensis (CAM)-induced aristolochic acid nephropathy (AAN). MATERIALS AND METHODS: Male Sprague-Dawley rats were gavaged with CAM extract every other week for 1, 4, 8 and 12 weeks, respectively. RESULTS: The rats in the model group showed chronic AAN as evidenced by worsening kidney function evaluate
PubMed: 27250112Seguridad y Precauciones
El uso de Aristolochia manshuriensis (conocida en la medicina tradicional china como Mu Tong o Guan-mu-tong) conlleva riesgos de seguridad extremadamente graves que deben ser considerados con máxima cautela. La presencia de ácidos aristolóquicos (AA) convierte a esta planta en una sustancia altamente nefrotóxica y carcinogénica. (1) Embarazo y lactancia: El consumo de Aristolochia manshuriensis está estrictamente contraindicado durante el embarazo y la lactancia. Los ácidos aristolóquicos son teratógenos potenciales y pueden atravesar la barrera placentaria, poniendo en riesgo el desarrollo fetal. No existe evidencia de seguridad para el uso materno, y el riesgo de daño renal irreversible en la madre o malformaciones en el feto supera cualquier posible beneficio terapéutico. En la lactancia, los compuestos pueden excretarse en la leche materna, exponiendo al lactante a toxinas que pueden causar daño renal temprano.
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