Aristolochia para Nefropatía por ácido aristolóquico
Aristolochia manshuriensis — 18 estudios científicos revisados
Strong¿Sirve Aristolochia para nefropatía por ácido aristolóquico?
Los ácidos aristolóquicos causan daño directo a las células de los túbulos renales, provocando insuficiencia renal progresiva.
Compuestos activos involucrados: Alcaloides, Flavonoides, Saponinas, Terpenos, ácido, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Aristolochia y nefropatía por ácido aristolóquico:
Toxicity of the Chinese herb mu tong (Aristolochia manshuriensis). What history tells us.
Plant sources of some traditional Chinese herbs may have changed over time. History records of herbal toxicity should be viewed critically when different plants might have been used under the same name in earlier eras. The current main source of the Chinese herb Mu Tong is Aristolochia manshuriensis. Examination of classical Chinese herbal literature revealed that until the mid 17th century the original source plants of Mu Tong had been several Akebia species. From the 17th century until the early 20th century Clematis species were the main source of Mu Tong.
PubMed: 12503251Pollen ultrastructure in Aristolochia manshuriensis and A. contorta (Aristolochiaceae).
Pollen ultrastructure has been studied in two relict and rare species of the genus Aristolochia, A. contorta Bunge and A. manshuriensis Kom. (Aristolochiaceae). Both species have inaperturate, spheroidal, sometimes distally monocolpate or distally bicolpate pollen grains.
PubMed: 29511834Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse.
Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways medicinally, including via ingestion of low doses for short periods of time. Non-alcoholic steatohepatitis (NASH) induced the hepatocyte injury and inflammation. The protective effects of AMK against NASH are unclear; therefore, in this study, the protective effects of AMK ethyl acetate extract were investigated in a high-fat diet (HFD)-induced NASH model. We found decreased hepatic steatosi
PubMed: 26726030Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity.
Aristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity. We found that OM reduced mouse mortality caused by AMK and attenuated AMK-induced acute nephrotoxicity in rats. OM enhanced hepatic Cyp 1a1/2 and renal Cyp 1a1 expression in rats, as well as CYP 1A1 expression in human renal tubular epithelial cells (HKCs). HKCs with ectopic CYP 1A1 expression were more tolerant to AA than the control cells.
PubMed: 27716846Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs.
ETHNOPHARMACOLOGICAL RELEVANCE: Aristolochia manshuriensis Kom (AMK), belonging to the Aristolochia family, is traditionally used in China to remove heart fire, promote dieresis, restore menstruation, and enhance milk secretion. The active constitutes of AMK are aristolochic acids (AAs, I and II) that are reported to cause serious side effects including nephrotoxicity and carcinogenicity. AIM OF THE STUDY: The tumorigenic role of AMK is far to be understood. We analyzed the toxicity reactions after long-term exposure of AMK in rats. MATERIALS AND METHODS: Sprague-Dawley rats underwent gavage w
PubMed: 30008395Seguridad y Precauciones
El uso de Aristolochia manshuriensis (conocida en la medicina tradicional china como Mu Tong o Guan-mu-tong) conlleva riesgos de seguridad extremadamente graves que deben ser considerados con máxima cautela. La presencia de ácidos aristolóquicos (AA) convierte a esta planta en una sustancia altamente nefrotóxica y carcinogénica. (1) Embarazo y lactancia: El consumo de Aristolochia manshuriensis está estrictamente contraindicado durante el embarazo y la lactancia. Los ácidos aristolóquicos son teratógenos potenciales y pueden atravesar la barrera placentaria, poniendo en riesgo el desarrollo fetal. No existe evidencia de seguridad para el uso materno, y el riesgo de daño renal irreversible en la madre o malformaciones en el feto supera cualquier posible beneficio terapéutico. En la lactancia, los compuestos pueden excretarse en la leche materna, exponiendo al lactante a toxinas que pueden causar daño renal temprano.
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