Árbol del pan para Actividad antihipertensiva
Artocarpus altilis — 16 estudios científicos revisados
Preliminary¿Sirve Árbol del pan para actividad antihipertensiva?
La investigación científica ha explorado el potencial de Árbol del pan (Artocarpus altilis) en relación con actividad antihipertensiva. Se han identificado 16 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: Alcaloides, Artocarpina, Flavonoides, Quercetina, Terpenos, Fenoles, Glutamato, Polifenoles, Leucina
Evidencia Científica
Los siguientes estudios han investigado la relación entre Árbol del pan y actividad antihipertensiva:
Development of Artocarpin-Loaded Chitosan Particles for Controlled Release and Inflammatory Application.
Artocarpin, a flavonoid derived from Artocarpus altilis, has been reported to exhibit anti-inflammatory and geroprotective activities. In this study, artocarpin was isolated from A. altilis heartwood via maceration followed by chromatographic purification, yielding 0.435% of dried extract with a purity of approximately 81%, as confirmed by HPLC. To enhance the physicochemical stability and biological performance of artocarpin, a chitosan-based microparticle delivery system was developed using 0.1% chitosan cross-linked with 0.5% sodium tripolyphosphate (5:1 ratio). The optimized formulation ac
PubMed: 41516792Electrospun PVP/HPBCD nanofiber topical drug delivery platform for enhanced skin permeability and anti-pollution bioactivity of Artocarpus altilis extract.
Artocarpus altilis methanolic extract (AAM) exhibits potent protective effects against particulate matter (PM)-induced skin damage; however, its poor aqueous solubility and limited skin permeability restrict its topical bioavailability. To overcome these limitations, we developed a polymer-based drug delivery system by fabricating electrospun nanofibers composed of polyvinylpyrrolidone (PVP), hydroxypropyl-β-cyclodextrin (HPBCD), and AAM. The optimized formulation engineering strategy enhanced AAM solubility via increased surface area, reduced crystallinity, and hydrogen bonding interactions w
PubMed: 41496494Breadfruit (Artocarpus altilis): Processing, nutritional quality, and food applications.
Breadfruit is an underutilized but highly nutritive crop containing complex carbohydrates while being low in fat. It is also a good source of essential amino acids (leucine, isoleucine, and valine). With a better understanding of breadfruit's morphology, its potential as a global solution to food security has been gaining popularity. Breadfruit has been forecasted to have a larger amount of suitable cultivable land area compared to major crops such as rice and wheat, making its cultivation more desirable. Due to its highly perishable nature, good post-harvesting and post-processing practices a
PubMed: 37006932Anti-cholinesterase potential of diverse botanical families from Malaysia: Evaluation of crude extracts and fractions from liquid-liquid extraction and acid-base fractionation.
ETHNOPHARMACOLOGICAL RELEVANCE: Enhancement of cholinergic functions in the brain via acetylcholinesterase inhibition is one of the main therapeutic strategies to improve symptoms associated with Alzheimer's or related cognitive deficits. There is a pathophysiological correlation between Alzheimer's and Diabetes Mellitus, as well as inflammation and oxidative stress that may cause cognitive decline. AIM OF THE STUDY: The present study was intended to evaluate anti-cholinesterase potential of 177 Malaysian plant extracts from 148 species known to have related ethnomedicinal uses such as anti-in
PubMed: 31419500Modulatory effects of methanol extract of Artocarpus altilis (Moraceae) on cadmium-induced hepatic and renal toxicity in male Wistar rats.
BACKGROUND: Cadmium (Cd) is an environmental risk factor with an established toxicity in animals. Therefore, natural antioxidants may be protective against Cd-toxicity. The study was designed to investigate the modulatory effects of methanol extract of Artocarpus altilis (AA) on oxidant-antioxidant balance and lipid profile in liver and kidney of Cd-exposed rats while quercetin (QE) served as standard. METHODS: Total phenolic content (TPC) and 2,2-diphenyl-1-picryldydrazyl (DPPH) radical scavenging activity of AA were assessed in vitro. In vivo, rats were orally treated with AA (200mg/kg) and
PubMed: 26905312Contexto Científico
En este estudio in vitro, se observó que los extractos de las hojas de esta planta mostraban actividad inhibitoria contra la acetilcolinesterasa (AChE), específicamente en fracciones menos polares tras la extracción ácida, lo que sugiere un potencial para el manejo de déficits cognitivos (PMID 31419500).
Seguridad y Precauciones
La seguridad en el consumo de Artocarpus altilis debe abordarse con cautela, especialmente debido a la presencia de compuestos bioactivos como la artocarpina y diversos flavonoides. En el caso de mujeres embarazadas y en periodo de lactancia, no existe evidencia científica suficiente (PMID 39840393) que garantice la inocuidad de los extractos concentrados o suplementos derivados de la planta sobre el desarrollo fetal o la composición de la leche materna. Debido a su potencial actividad antiinflamatoria y su influencia en procesos metabólicos, se recomienda evitar el uso de extractos terapéuticos durante estas etapas para prevenir cualquier alteración endocrina o inmunológica no estudiada en humanos. Para niños menores de 12 años, el uso de extractos debe ser estrictamente supervisado por un pediatra, ya que la toxicidad potencial en sistemas en desarrollo y la falta de estudios de dosificación pediática limitan su uso seguro como coadyuvante. En cuanto a interacciones farmacológicas, la planta presenta riesgos significativos con fármacos específicos. Debido a sus propiedades reportadas en la gestión de la diabetes (PMID 39840393), existe un riesgo de hipoglucemia si se combina con metformina u otros antidiabéticos, al potenciar el efecto hipoglucemiante.
Otras plantas estudiadas para Actividad antihipertensiva
Perfil completo: Ver todos los usos y evidencia de Árbol del pan →