Árbol del pan para Crecimiento de células cancerosas (en modelos in vitro)
Artocarpus altilis — 14 estudios científicos revisados
Preliminary¿Sirve Árbol del pan para crecimiento de células cancerosas (en modelos in vitro)?
La quercetina del fruto induce apoptosis mediante la vía mitocondrial, regulando genes BAX y BCL-2 (PMID 30614306).
Compuestos activos involucrados: Alcaloides, Artocarpina, Flavonoides, Quercetina, Terpenos, Fenoles, Glutamato, Polifenoles, Leucina
Evidencia Científica
Los siguientes estudios han investigado la relación entre Árbol del pan y crecimiento de células cancerosas (en modelos in vitro):
Development of Artocarpin-Loaded Chitosan Particles for Controlled Release and Inflammatory Application.
Artocarpin, a flavonoid derived from Artocarpus altilis, has been reported to exhibit anti-inflammatory and geroprotective activities. In this study, artocarpin was isolated from A. altilis heartwood via maceration followed by chromatographic purification, yielding 0.435% of dried extract with a purity of approximately 81%, as confirmed by HPLC. To enhance the physicochemical stability and biological performance of artocarpin, a chitosan-based microparticle delivery system was developed using 0.1% chitosan cross-linked with 0.5% sodium tripolyphosphate (5:1 ratio). The optimized formulation ac
PubMed: 41516792Electrospun PVP/HPBCD nanofiber topical drug delivery platform for enhanced skin permeability and anti-pollution bioactivity of Artocarpus altilis extract.
Artocarpus altilis methanolic extract (AAM) exhibits potent protective effects against particulate matter (PM)-induced skin damage; however, its poor aqueous solubility and limited skin permeability restrict its topical bioavailability. To overcome these limitations, we developed a polymer-based drug delivery system by fabricating electrospun nanofibers composed of polyvinylpyrrolidone (PVP), hydroxypropyl-β-cyclodextrin (HPBCD), and AAM. The optimized formulation engineering strategy enhanced AAM solubility via increased surface area, reduced crystallinity, and hydrogen bonding interactions w
PubMed: 41496494Herbal Medicines as Complementary Therapy for Managing Complications in COVID-19 Patients with Diabetes Mellitus.
Diabetes mellitus (DM) is recognized and classified as a group of conditions marked by persistent high blood glucose levels. It is also an inflammatory condition that may influence concurrent disease states, including Coronavirus Disease 2019 (COVID-19). Currently, no effective drug has been found to treat COVID-19, especially in DM patients. Many herbal medicines, such as the well-known Andrographis paniculata, have been explored as drugs and complementary therapies due to their antidiabetic, antibacterial, antiviral, anti-inflammatory, and immunomodulatory effects. This study aimed to examin
PubMed: 39840393In vitro antioxidant and anti-inflammatory properties of Artocarpus altilis (Parkinson) Fosberg (seedless breadfruit) fruit pulp protein hydrolysates.
Protein hydrolysates from dietary sources possess many physiological and biological properties. Artocarpus altilis is an evergreen multipurpose plant with many benefits. Therefore, this study evaluates in vitro antioxidant and anti-inflammatory properties of A. altilis protein hydrolysates. Protein was isolated from A.
PubMed: 36707546Effect of geranylated dihydrochalcone from Artocarpus altilis leaves extract on Plasmodium falciparum ultrastructural changes and mitochondrial malate: Quinone oxidoreductase.
Nearly half of the world's population is at risk of being infected by Plasmodium falciparum, the pathogen of malaria. Increasing resistance to common antimalarial drugs has encouraged investigations to find compounds with different scaffolds. Extracts of Artocarpus altilis leaves have previously been reported to exhibit in vitro antimalarial activity against P. falciparum and in vivo activity against P. berghei.
PubMed: 36565667Seguridad y Precauciones
La seguridad en el consumo de Artocarpus altilis debe abordarse con cautela, especialmente debido a la presencia de compuestos bioactivos como la artocarpina y diversos flavonoides. En el caso de mujeres embarazadas y en periodo de lactancia, no existe evidencia científica suficiente (PMID 39840393) que garantice la inocuidad de los extractos concentrados o suplementos derivados de la planta sobre el desarrollo fetal o la composición de la leche materna. Debido a su potencial actividad antiinflamatoria y su influencia en procesos metabólicos, se recomienda evitar el uso de extractos terapéuticos durante estas etapas para prevenir cualquier alteración endocrina o inmunológica no estudiada en humanos. Para niños menores de 12 años, el uso de extractos debe ser estrictamente supervisado por un pediatra, ya que la toxicidad potencial en sistemas en desarrollo y la falta de estudios de dosificación pediática limitan su uso seguro como coadyuvante. En cuanto a interacciones farmacológicas, la planta presenta riesgos significativos con fármacos específicos. Debido a sus propiedades reportadas en la gestión de la diabetes (PMID 39840393), existe un riesgo de hipoglucemia si se combina con metformina u otros antidiabéticos, al potenciar el efecto hipoglucemiante.
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