Atropa para Síndrome anticolinérgico central
Atropa belladonna — 3 estudios científicos revisados
Strong¿Sirve Atropa para síndrome anticolinérgico central?
Los alcaloides tropánicos bloquean los receptores de acetilcolina en el sistema nervioso, provocando confusión, alucinaciones y convulsiones.
Compuestos activos involucrados: Acetilcolina, Alcaloides, Atropina, Escopolamina, Flavonoides, Hiosciamina
Evidencia Científica
Los siguientes estudios han investigado la relación entre Atropa y síndrome anticolinérgico central:
Seizures caused by ingestion of Atropa belladonna in a homeopathic medicine in a previously well infant: case report and review of the literature.
Atropa belladonna is a poisonous plant that can cause anticholinergic effects when ingested. Roots, leaves, and fruits of the plant contain the alkaloids atropine, hyoscyamine, and scopolamine, which can lead to an anticholinergic toxidrome; however, not all characteristics of the toxidrome are necessarily present in each case of poisoning. We present an infant who suffered serious seizures after ingestion of a homeopathic agent containing A. belladonna. The 20-day-old infant arrived at the emergency department with fever and generalized seizures for 30 minutes, 2 hours after ingesting the cor
PubMed: 24105354Atropa belladonna intoxication: a case report.
Atropa belladonna is a poisonous plant also called deadly nightshade. Its roots, leaves and fruits contain alkaloids: atropine, hyocyamine and scopolamine. The risk of poisoning in children is important because of possible confusion with other berries. Atropa belladonna acute intoxication is a severe condition, it's should be considered in the presence of anti-cholinergic toxidrome, the differential diagnosis include other plants or psychoactive drugs containing atropine. The treatment is mainly symptomatic including gastrointestinal decontamination with activated charcoal.
PubMed: 22655106The pattern of coding sequences in the chloroplast genome of Atropa belladonna and a comparative analysis with other related genomes in the nightshade family.
Atropa belladonna is a valuable medicinal plant and a commercial source of tropane alkaloids, which are frequently utilized in therapeutic practice. In this study, bioinformaticmethodologies were used to examine the pattern of coding sequences and the factors thatmight influence codon usage bias in the chloroplast genome of Atropa belladonna andother nightshade genomes. The chloroplast engineering being a promising field in modernbiotechnology, the characterization of chloroplast genome is very important. The resultsrevealed that the chloroplast genomes of Nicotiana tabacum, Solanum lycopersic
PubMed: 36617650Seguridad y Precauciones
La seguridad en el uso de Atropa belladonna es extremadamente crítica debido a su alta toxicidad. En el contexto de embarazo y lactancia, el uso de esta planta está estrictamente contraindicado. Los alcaloides tropánicos, como la atropina y la escopolamina, pueden atravesar la barrera placentaria y afectar el desarrollo neurológico del feto, pudiendo causar malformaciones o alteraciones en el sistema nervioso central del neonato. Durante la lactancia, estos compuestos se excretan en la leche materna, lo que representa un riesgo de intoxicación aguda para el lactante, manifestándose potencialmente como sedación extrema, convulsiones o crisis autonómicas. En niños menores de 12 años, el riesgo es desproporcionadamente alto. La literatura médica documenta casos de intoxicación grave en infantes, incluso con dosis mínimas utilizadas en remedios homeopáticos, que han resultado en síndromes anticolinérgicos centrales, convulsiones generalizadas y, en casos extremos, la muerte [PMID 24105354].
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