Calceolaria parviflora para Interferencia neuroquímica
Calceolaria parviflora — 6 estudios científicos revisados
Preliminary¿Sirve Calceolaria parviflora para interferencia neuroquímica?
Extractos de especies de Calceolaria muestran inhibición de las enzimas acetilcolinesterasa y butirilcolinesterasa, lo que puede afectar la regulación de los neurotransmisores [PMID 24416779].
Compuestos activos involucrados: Alcaloides, Calceolariosido, Flavonoides, Glucósidos, Saponinas, Terpenoides, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Calceolaria parviflora y interferencia neuroquímica:
Reconsideration of the Structures of Stemara-13(14)-en-18-ol and Related Diterpene Natural Products: Vinylic Hydrogen Chemical Shifts Are Key.
The reported synthesis of stemara-13(14)-en-18-ol, which revealed that the structure of this natural product was misassigned, prompted an investigation using density functional theory methods into the structural reassignment of this natural product and related diterpenoids extracted from Calceolaria plants. 1H and 13C chemical shift predictions led to the reassignment of relative configuration, and in one case the carbon skeleton, of several diterpenoids from Calceolaria. In many of these cases, the chemical shift of the vinylic hydrogen was found to be diagnostic.
PubMed: 35952375Biopesticides from plants: Calceolaria integrifolia s.l.
The effects of persistent organic pollutants (POPs) on humans and biodiversity are multiple and varied. Nowadays environmentally-friendly pesticides are strongly preferred to POPs. It is noteworthy that the crop protection role of pesticides and other techniques, i.e. biopesticides, plant extracts, prevention methods, organic methods, evaluation of plant resistance to certain pests under an integrated pest management (IPM), could improve the risks and benefits which must be assessed on a sound scientific basis. For this directive it is crucial to bring about a significant reduction in the use
PubMed: 24893349Inhibitory effect of sterols from Ruprechtia triflora and diterpenes from Calceolaria pinnifolia on the growth of Mycobacterium tuberculosis.
Bioactivity-guided fractionation of the CH 2 Cl 2 /MeOH extract of the aerial part of Ruprechtia triflora Griseb. led to the identification of several sterols and a triterpene as the active components against Mycobacterium tuberculosis. This is the first report of a chemical investigation of a member of the genus Ruprechtia. The novel acylated sterol, 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-yl stearate, was isolated and its structure determined on the basis of spectral evidence including NMR (especially selective 1D NOE, selective 1D TOCSY, HSQC, HMBC) and MS (HR-FAB). In addition, sever
PubMed: 12898418Identification and determination of the inulin content in the roots of the Northeast Brazilian species Pombalia calceolaria L.
A polysaccharide was extracted from the roots of Pombalia calceolaria, a plant used in folk medicine in Northeastern Brazil, by decoction followed by precipitation with methanol, yielding a concentration of 13.0% w/w, and purification with acetone. The molar mass peak was estimated to be 4.0×10(3)Da using gel permeation chromatography (GPC). Polarized light photomicrography of histological sections revealed the presence of inulin in the cortical parenchyma. The chemical composition of inulin was identified by 1D and 2D NMR and FT-IR spectroscopy and the findings were compared with the literatu
PubMed: 27261763Plant species as a therapeutic resource in areas of the savanna in the state of Pernambuco, Northeast Brazil.
ETHNOPHARMACOLOGICAL RELEVANCE: Ethnobotanical studies have contributed significantly in research of plants with therapeutic potential. The aim of the present study was to learn about the use of native medicinal plants cited by the traditional population in "cerradão" (savanna woodland) areas in Northeast Brazil, providing data on therapeutic indications of the species used and their versatility. MATERIALS AND METHODS: Semi-structured interviews were conducted on the basis of a standardized questionnaire designed for key informants selected using the "snowball" technique. The selection of plan
PubMed: 26026371Seguridad y Precauciones
La seguridad en el uso de Calceolaria parviflora requiere una precaución extrema debido a la falta de estudios clínicos exhaustivos en humanos y a la presencia de metabolitos secundarios con actividad biológica significativa. En cuanto al embarazo y la lactancia, no existe evidencia científica que garantice la inocuidad de esta especie para mujeres gestantes o en periodo de lactancia; por lo tanto, su uso está estrictamente contraindicado en estos estados, ya que los componentes químicos de la planta podrían atravesar la barrera placentaria o excretarse en la leche materna, con riesgos potenciales para el desarrollo fetal o neonatal aún no cuantificados. Para niños menores de 12 años, el uso debe evitarse por completo, dado que sus sistemas metabólicos, específicamente las enzimas hepáticas encargadas de la detoxificación, no están plenamente desarrollados, lo que incrementa el riesgo de toxicidad sistémica. En términos de interacciones farmacológicas, se debe tener especial cuidado con la administración de fármacos que afecten la coagulación, como la warfarina, debido a que compuestos como el calceolariosido A han demostrado tener efectos sobre la agregación plaquetaria mediante mecanismos dependientes de calcio [PMID 8372152], lo que podría potenciar peligrosamente el riesgo de hemorragias. Asimismo, la interacción con la metformina o fármacos para la diabetes debe monitorearse si se sospecha de efectos metabólicos, aunque no hay datos específicos. Respecto a los antihipertensivos, la presencia de compuestos con actividad inhibidora de la colinesterasa (AChE y BChE) en el género Calceolaria [PMID 24416779] sugiere que el consumo de la planta podría alterar la neurotransmisión colinérgica, interfiriendo con medicamentos que regulan el sistema nervioso autónomo.
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