Caulerpa para Efecto pro-apoptótico en células cancerosas de colon
Caulerpa lentillifera — 6 estudios científicos revisados
Preliminary¿Sirve Caulerpa para efecto pro-apoptótico en células cancerosas de colon?
A nivel molecular, los polisacáricos pueden inducir la apoptosis (muerte celular programada) en células de cáncer de colon mediante la vía p53/Bax/Caspase-3 y la acumulación de especies reactivas de oxígeno (ROS) (PMID 40157667).
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Caulerpa y efecto pro-apoptótico en células cancerosas de colon:
Molecular mechanisms underlying the anti-Colon Cancer effects of Caulerpa lentillifera polysaccharides (CLP).
Colon cancer (CC) ranks is the second leading cause of cancer-related deaths globally. Despite chemotherapy being a primary treatment its effectiveness significantly declines in advanced in stage. Emerging evidence suggests that dietary components particularly polysaccharides, play a role in CC progression. This study employed multi-omics and network pharmacology to elucidate the mechanisms underlying the apoptotic effects of Caulerpa lentillifera polysaccharide (CLP) in CC, validated through in vitro and in vivo experiments. Transcriptomics and network pharmacology analysis identified the p53
PubMed: 40157667The potential of polysaccharide extracts from Caulerpa lentillifera waste.
Caulerpa is a marine macroalgae and is rich in polysaccharides, which have the potential for immunostimulatory and anticoagulant activity. The objective of this work was to increase the value of C. lentillifera waste by polysaccharide extraction. A polysaccharide yield of about 25% of dry weight was obtained under the following optimized conditions: two-stage extraction (60 min/stage) using a ratio of 1:15 (w/v) at 90 °C, and 2× precipitation by the final concentration of 75% ethanol. The polysaccharide extracts contained a non-reducing sugar that accounted for 44% of weight extracts as a majo
PubMed: 32553952Caulerpa lentillifera polysaccharides enhance the immunostimulatory activity in immunosuppressed mice in correlation with modulating gut microbiota.
In this study, the immunostimulatory activity of Caulerpa lentillifera polysaccharides (CLP) was elucidated in cytoxan (CTX)-induced immunosuppressed BALB/c mice. The results showed that CLP ameliorated the CTX-evoked damage to body weight, colon length and thymus/spleen indexes and enhanced the secretions of interleukin (IL)-1β, tumor necrosis factor (TNF)-α and superoxidase dismutase (SOD) in serum and thymic, splenic and colonic tissues of the immunosuppressed mice. Besides, CLP promoted the production of secretory immunoglobulin A (SIgA) and mucin2 in the colonic tissue of the immunosuppre
PubMed: 31271400The potential anticoagulant property of
BACKGROUND: Anticoagulants have been used in the treatment of several circulatory diseases and thrombotic disorders, and in the blood sampling for hematologic analysis. Sulfated polysaccharides (SP), which have anticoagulant properties, are found in most seaweeds, including OBJECTIVE: The study generally aimed to evaluate the potential anticoagulant property of METHODOLOGY: The whole plant of fresh RESULTS: Phase one results revealed significant differences on the clotting time between the negative and the positive and experimental groups (
PubMed: 28936148Phytochemical analysis, antioxidant activity, and cytotoxic effects of Caulerpa lentillifera extracts inducing cell apoptosis and sub-G/G0-G1 cell cycle arrest in KON oral cancer cells.
BACKGROUND: Marine algae have excellent phytoconstituents with notable biological activity and bioactive therapeutic benefits, but the anti-oral cancer activity of Caulerpa lentillifera (C. lentillifera) has not been widely studied. This study aimed to explore the anti-cancer properties of C. lentillifera to gain insights into possible treatment approaches. METHODS: The three C.
PubMed: 40069755Seguridad y Precauciones
En relación con el embarazo y la lactancia, no existen estudios clínicos suficientes en humanos que determinen la seguridad del consumo de Caulerpa lentillifera en estas etapas. Debido a que los polisacáridos de esta alga pueden alterar el metabolismo de los ácidos biliares y la microbiota intestinal (PMID 40044008), existe el riesgo de que estas alteraciones afecten el desarrollo fetal o la composición de la leche materna. Se recomienda evitar su consumo terapéutico o concentrado durante la gestación y el periodo de lactancia por precaución, hasta que se disponga de evidencia toxicológica clara. Para niños menores de 12 años, la seguridad no ha sido establecida. El sistema digestivo y metabólico en desarrollo es altamente sensible a cambios en la absorción de lípidos y la actividad de la lipasa, procesos que el polisacárido de Caulerpa puede modular (PMID 38228205). Por tanto, su uso en población pediátrica debe ser evitado sin supervisión médica estricta.
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