Ceiba para Proliferación de células cancerosas (in vitro)
Ceiba pentandra — 6 estudios científicos revisados
Preliminary¿Sirve Ceiba para proliferación de células cancerosas (in vitro)?
Extractos de hojas muestran actividad antiproliferativa mediante la inducción de la apoptosis y la detención del ciclo celular en el punto de control G1/S, afectando genes como AKT1 y STAT3 [PMID...
Compuestos activos involucrados: Alcaloides, Flavonoides, Glucósidos, Kaempferol, Linarina, Terpenos, Compuestos fenólicos, Sitosterol
Evidencia Científica
Los siguientes estudios han investigado la relación entre Ceiba y proliferación de células cancerosas (in vitro):
Integrative network pharmacology and molecular dynamics analysis of Ceiba pentandra compounds with experimental support for colorectal cancer therapy.
This study investigated the anticancer potential of Ceiba pentandra leaf extract against colorectal cancer (CRC) through integrated computational and experimental approaches. Twenty-nine phytochemicals were identified, of which ten compounds with high gastrointestinal absorption and drug-like properties were shortlisted. SwissTargetPrediction and network pharmacology analyses (GeneMANIA, STRING, Cytoscape) revealed 267 common targets between C. pentandra compounds and CRC-associated genes. Key hub genes included AKT1, TP53, and STAT3.
PubMed: 41395189A bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells.
ETHNOPHARMACOLOGICAL RELEVANCE: Ceibapentandra (L.) Gaertn. (Malvaceae) has been used in Africa traditionally to manage a variety of illnesses, including cancer. The hydroethanolic extract of the leaves of C. pentandra has been shown to possess antiproliferative activity. However, the fractionation of antiproliferative bioactive constituents from the leaves of C.
PubMed: 39814326Diversity of Endophytic Fungi Isolated from the Bark of Ceiba pentandra (L.) Gaertn., (Bombacaceae) and Antibacterial Potential of Secalonic Acid A Produced by Diaporthe searlei EC 321.
The objective of this study was to study the diversity of endophytic fungi isolated from Ceiba pentandra and to isolate their bioactive chemical compounds. The methodology used during this study consisted in isolating endophytic fungi from the bark of C. pentandra on Potato Agar. The isolates obtained were identified on the basis of the ITS regions of their ribosomal DNA. Antibacterial screening of the mycelium of endophytic fungi isolated was evaluated against multidrug-resistant E.
PubMed: 37814192Ceiba pentandra cellulose crosslinked with citric acid for drug release systems.
An alternative for the production of drug delivery system is proposed based on the Ceiba pentandra milkweed. The kapok cellulose was chemically crosslinked with citric acid (CA) at different CA proportions, and loaded with chlorhexidine diacetate (CHX) at different concentrations. Cellulose crosslinking was followed with FTIR and XPS analysis, and the CHX loading was determined using elemental analysis. In vitro studies showed a burst release within the first 2-3 h and the drug release kinetics was described with several models. In addition, the crosslinked Ceiba pentandra fibers did not exhib
PubMed: 33957461Ethyl acetate extract of Ceiba pentandra (L.) Gaertn. reduces methotrexate-induced renal damage in rats via antioxidant, anti-inflammatory, and antiapoptotic actions.
UNLABELLED: Methotrexate (MTX) is a chemotherapeutic agent and an immunosuppressant used to treat cancer and autoimmune diseases. However, its use is limited by its multi-organ toxicity, including nephrotoxicity, which is related to MTX-driven oxidative stress. Silencing oxidative stressors is therefore an important strategy in minimizing MTX adverse effects.Medicinal plants rich in phenolic compounds are probable candidates to overcome these oxidants. Herein, C. pentandra ethyl acetate extract showed powerful in vitro radical-scavenging potential (IC50 = 0.0716) comparable to those of the sta
PubMed: 32953564Seguridad y Precauciones
La seguridad en el uso de Ceiba pentandra debe abordarse con extrema cautela debido a la falta de ensayos clínicos controlados en humanos que establezcan una dosis terapéutica segura y estandarizada. En el caso de mujeres embarazadas y en periodo de lactancia, el uso de esta planta está estrictamente contraindicado. Existe evidencia etnobotánica que señala que el exudado de la corteza posee propiedades abortivas, lo que sugiere un riesgo significativo de interrupción del embarazo o efectos teratogénicos no estudiados. No hay datos suficientes para garantizar la ausencia de transferencia de compuestos bioactivos a través de la leche materna, por lo que se debe evitar su consumo durante la lactancia para prevenir riesgos de toxicidad en el lactante. En niños menores de 12 años, la seguridad no ha sido establecida; la fisiología pediátrica es altamente sensible a compuestos como los flavonoides y lactonas presentes en la planta, y la falta de estudios de toxicidad en pediatría impide recomendar su uso en esta población. Respecto a las interacciones farmacológicas, se debe tener precaución con la warfarina y otros anticoagulantes, ya que la presencia de compuestos con actividad biológica podría alterar la cascada de coagulación.
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