Flor de manita para Reducción de secreción intestinal
Chiranthodendron pentadactylon — 6 estudios científicos revisados
Preliminary¿Sirve Flor de manita para reducción de secreción intestinal?
La epicatequina aislada de la planta muestra actividad antisecretora contra las toxinas de Vibrio cholera y Escherichia coli en modelos experimentales [PMID 22884870].
Compuestos activos involucrados: Flavonoides, Terpenos, Ácido ferúlico, ácido
Evidencia Científica
Los siguientes estudios han investigado la relación entre Flor de manita y reducción de secreción intestinal:
Anti-diarrheal activity of (-)-epicatechin from Chiranthodendron pentadactylon Larreat: experimental and computational studies.
ETHNOPHARMACOLOGICAL RELEVANCE: Chiranthodendron pentadactylon Larreat is frequently used in Mexican traditional medicine as well as in Guatemalan for several medicinal purposes, including their use in the control of diarrhea. AIM OF THE STUDY: This work was undertaken to obtain additional information that support the traditional use of Chiranthodendron pentadactylon Larreat, on pharmacological basis using the major antisecretory isolated compound from computational, in vitro and in vivo experiments. MATERIALS AND METHODS: (-)-Epicatechin was isolated from ethyl acetate fraction of the plant c
PubMed: 22884870In vitro susceptibility of Entamoeba histolytica and Giardia lamblia to plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders.
In our search for new antiprotozoal chemotherapy, we collected a selection of 26 plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. Methanolic extracts of these species were screened for their antiprotozoal activity against Entamoeba histolytica and Giardia lamblia trophozoites using in vitro tests. Among the tested extracts, the derivates of following species showed selectivity and significant antiprotozoal activity: Chiranthodendron pentadactylon, Annona cherimola and Punica granatum were the most active on Entamoeba histolytica with IC50 < 30 microg
PubMed: 16846708Antisecretory activity from the flowers of Chiranthodendron pentadactylon and its flavonoids on intestinal fluid accumulation induced by Vibrio cholerae toxin in rats.
ETHNOPHARMACOLOGICAL RELEVANCE: The flowers of Chiranthodendron pentadactylon Larreat. (Sterculiaceae) has been traditionally used as folk medicine in Mexico for the treatment of gastrointestinal disorders such as diarrhea and dysentery. AIM OF THE STUDY: This study aimed to assess the antisecretory activity which supports the therapeutic use of Chiranthodendron pentadactylon and its flavonoids to treat diarrhea. MATERIALS AND METHODS: The methanol extract of Chiranthodendron pentadactylon, subsequent fractions, and flavonoids were evaluated on cholera toxin-induced intestinal secretion in rat
PubMed: 19781621Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico.
Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens show
PubMed: 16174555Antibacterial properties of some plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders.
Antibacterial properties of aqueous and methanolic extracts of 26 medicinal plants used in Mexico to treat gastrointestinal disorders were tested against eight different species of enteropathogens: two Escherichia coli species; two Shigella sonnei species; two Shigella flexneri species; and two Salmonella sp. species. The results showed that all crude extracts exhibited antibacterial activity, at least against one of the microorganisms tested, at concentrations of 8 mg/mL or lower. The extracts from Caesalpinia pulcherria, Chiranthodendron pentadactylon, Cocos nucifera, Geranium mexicanum (aer
PubMed: 16005589Seguridad y Precauciones
La seguridad en el uso de la Flor de manita (Chiranthodendron pentadactylon) debe abordarse con extrema precaución, ya que la mayor parte de su evidencia científica se basa en modelos animales o estudios in vitro, careciendo de ensayos clínicos extensos en humanos que establezcan una dosis terapéutica segura y estandarizada. No existe una dosis máxima establecida para el consumo humano, lo que implica un riesgo inherente de toxicidad por sobredosis. En el caso de mujeres embarazadas y durante la lactancia, el uso de esta planta está estrictamente contraindicado; debido a la presencia de alcaloides y compuestos fenólicos complejos, no se puede garantizar la ausencia de efectos teratogénicos (daños al desarrollo fetal) o la transferencia de metabolitos activos a través de la leche materna, lo que podría comprometer la salud del neonato. Para niños menores de 12 años, su uso no debe realizarse, dado que sus sistemas metabólicos, específicamente la maduración renal y hepática, son altamente vulnerables a compuestos bioactivos no regulados. Respecto a las interacciones farmacológicas, se debe tener especial cuidado con la warfarina y otros anticoagulantes, ya que los flavonoides presentes (como la epicatequina y el tiliroside) podrían alterar la cascada de coagulación, incrementando el riesgo de hemorragias. Asimismo, existe un riesgo potencial de interacción con la metformina y otros fármacos para la diabetes; aunque el extracto de la flor muestra efectos antioxidantes en riñones con hiperglucemia [PMID 37896035], la manipulación de los niveles de glucosa y la función renal mediante compuestos no estandarizados podría causar hipoglucemia o desequilibrios electrolíticos impredecibles.
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