Quina amarilla para antimalarial
Cinchona calisaya — 7 estudios científicos revisados
Preliminary¿Sirve Quina amarilla para antimalarial?
La investigación científica ha explorado el potencial de Quina amarilla (Cinchona calisaya) en relación con antimalarial. Se han identificado 7 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: Alcaloides, Cinchona, Cinconidina, Cinconina, Flavonoides, Quinidina, Quinina, Saponinas, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Quina amarilla y antimalarial:
Artemisinin-hydroxychloroquine combination from traditional antimalarial medicine attenuates pulmonary fibrosis via PI3K/AKT/GSK3β-mediated inhibition of epithelial-mesenchymal transition.
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisinin and hydroxychloroquine, derived respectively from Artemisia annua L. (Qinghao) and Cinchona calisaya Wedd., have been widely used for centuries to treat malaria and inflammatory disorders. In addition to their antimalarial activity, these compounds exhibit multifunctionality, including anti-inflammatory, antifibrotic, and immunomodulatory effects. Although preliminary studies suggested that the artemisinin-hydroxychloroquine (AH) combination may attenuate idiopathic pulmonary fibrosis (IPF), its underlying mechanisms remain poorly understood. AIM OF
PubMed: 41076144Effect of Medium pH and Light on Quinidine Production in Cinchona calisaya Wedd. Endophytic Fungi.
OBJECTIVES: Quinidine has pharmaceutical importance as an antimalarial, antiarrhythmia, antimicrobial, anticancer, antioxidant, astringent, and bitter flavoring agent. Quinidine is in high demand, yet its production from the bark of the quina tree (Cinchona calisaya) is limited. Quinidine production from quina tree fungal endophytes, namely Aspergillus sydowii, Diaporthe sp., Diaporthe lithicola, Fusarium oxysporum, and F. solani is lower than the quinidine content of the tree bark. This study attempted to increase quinidine production from these fungi.
PubMed: 33900523Phylogeny Predicts the Quantity of Antimalarial Alkaloids within the Iconic Yellow
Considerable inter- and intraspecific variation with respect to the quantity and composition of plant natural products exists. The processes that drive this variation remain largely unknown. Understanding which factors determine chemical diversity has the potential to shed light on plant defenses against herbivores and diseases and accelerate drug discovery. For centuries,
PubMed: 28382048Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil.
For centuries, malaria was treated with the bark of Cinchona calisaya and Cinchona succirubra plants named "quinas" in Brazil, from which the quinine molecule was isolated. Other plant species known also as "quinas" are used to treat fever and malaria, like Deianira erubescens (roots and leaves), Strychnos pseudoquina (bark), and Remijia ferruginea (bark). Based on this popular knowledge, we evaluated the in vivo antimalarial activity of the ethanol crude extracts of these plant species in mice infected with Plasmodium berghei. Only Remijia ferruginea showed antimalarial activity, reducing par
PubMed: 12860318Medicinal plants used in the treatment of Malaria: A key emphasis to Artemisia, Cinchona, Cryptolepis, and Tabebuia genera.
Malaria is one of the life-threatening parasitic diseases that is endemic in tropical areas. The increased prevalence of malaria due to drug resistance leads to a high incidence of mortality. Drug discovery based on natural products and secondary metabolites is considered as alternative approaches for antimalarial therapy. Herbal medicines have advantages over modern medicines, including fewer side effects, cost-effectiveness, and affordability encouraging the herbal-based drug discovery. Several naturally occurring, semisynthetic, and synthetic antimalarial medications are on the market.
PubMed: 32022345Seguridad y Precauciones
La seguridad en el uso de la Quina amarilla (Cinchona calisaya) es un tema de extrema precaución debido a la presencia de alcaloides potentes como la quinina y la cinconina, los cuales poseen una ventana terapéutica estrecha, lo que significa que la diferencia entre una dosis útil y una tóxica es pequeña. En relación con el embarazo y la lactancia, no existe evidencia científica suficiente que garantice la seguridad para el desarrollo fetal o neonatal; por lo tanto, su uso está contraindicado en mujeres embarazadas debido al riesgo potencial de efectos teratogénicos o toxicidad sistémica. Durante la lactancia, la transferencia de alcaloides a través de la leche materna puede exponer al lactante a riesgos de toxicidad neurológica o cardíaca, por lo que se recomienda evitar su consumo. Para niños menores de 12 años, el uso de extractos de Cinchona calisaya debe evitarse estrictamente, ya que sus sistemas metabólicos y fisiológicos en desarrollo no pueden procesar adecuadamente la carga de alcaloides, aumentando el riesgo de intoxicación aguda. En cuanto a las interacciones farmacológicas, la cinconina y otros alcaloides pueden interactuar peligrosamente con la warfarina, ya que pueden alterar la coagulación sanguínea y aumentar el riesgo de hemorragias. Asimismo, pueden potenciar o interferir con fármacos antihipertensivos debido a sus efectos sobre el sistema cardiovascular, y existe un riesgo de interacción con la metformina si se producen alteraciones en el metabolismo de la glucosa o la función renal.
Otras plantas estudiadas para antimalarial
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