Quina amarilla para Inflamación crónica y aguda
Cinchona calisaya — 7 estudios científicos revisados
Moderate¿Sirve Quina amarilla para inflamación crónica y aguda?
Este valor medicinal no solo fue un recurso económico, sino que fue validado por la ciencia moderna; estudios sobre sus alcaloides, como la cinconina, han explorado sus propiedades antiinflamatorias, anticancerígenas y antiparasitarias [PMID 38031797].
Compuestos activos involucrados: Alcaloides, Cinchona, Cinconidina, Cinconina, Flavonoides, Quinidina, Quinina, Saponinas, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Quina amarilla y inflamación crónica y aguda:
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids.
BACKGROUND: Cinchonine is one of the Cinchona alkaloids that is commercially extracted from the Peruvian bark of Cinchona officinalis L. (Family: Rubiaceae). It is also obtained in much lower quantities from other species of Cinchona, such as Cinchona calisaya, Cinchona succirubra, and Cinchona pubescens, and in some other plants, such as Remijia peruviana. Cinchonine has been historically used as an anti-malarial agent. It also has a wide range of other biological properties, including anti-cancer, anti-obesity, anti-inflammatory, anti-parasitic, antimicrobial, anti-platelet aggregation, and
PubMed: 38031797Medicinal plants, human health and biodiversity: a broad review.
Biodiversity contributes significantly towards human livelihood and development and thus plays a predominant role in the well being of the global population. According to WHO reports, around 80 % of the global population still relies on botanical drugs; today several medicines owe their origin to medicinal plants. Natural substances have long served as sources of therapeutic drugs, where drugs including digitalis (from foxglove), ergotamine (from contaminated rye), quinine (from cinchona), and salicylates (willow bark) can be cited as some classical examples.Drug discovery from natural sources
PubMed: 25001990Natural Products That Changed Society.
Until the end of the 19th century all drugs were natural products or minerals. During the 19th century chemists succeeded in isolating pure natural products such as quinine, morphine, codeine and other compounds with beneficial effects. Pure compounds enabled accurate dosing to achieve serum levels within the pharmacological window and reproducible clinical effects. During the 20th and the 21st century synthetic compounds became the major source of drugs. In spite of the impressive results achieved within the art of synthetic chemistry, natural products or modified natural products still const
PubMed: 33925870The Fever Tree: from Malaria to Neurological Diseases.
This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine. Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars. Over those 400 years, the medical use of cinchona alkaloids has evolved from bark extracts to chemical synthesis and controlled clinical trials. At the present time, the use of quinine and quinidine has declined, to a large extent due to their toxicity. However, quinine is still being pres
PubMed: 30477182Glycyrrhizin alleviates the toxicity of hydroxychloroquine in treating oral lichen planus by occupying heat shock protein 90 alpha.
BACKGROUND: Oral lichen planus (OLP) is a common chronic inflammatory disease with the potential of malignant transformation. Hydroxychloroquine (HCQ), derived from quinine originating from Cinchona spp. bark, is a commonly prescribed off-label for OLP. However, it lacks robust evidence-based medicine practice, as well as theoretical guidance for its pharmacodynamic targets and for mitigating adverse reactions. PURPOSE: To compare the efficacy of HCQ with first-line treatment prednisone for treating severe erosive OLP and to identify compatible phytomedicine that is reasonably available based
PubMed: 39550918Seguridad y Precauciones
La seguridad en el uso de la Quina amarilla (Cinchona calisaya) es un tema de extrema precaución debido a la presencia de alcaloides potentes como la quinina y la cinconina, los cuales poseen una ventana terapéutica estrecha, lo que significa que la diferencia entre una dosis útil y una tóxica es pequeña. En relación con el embarazo y la lactancia, no existe evidencia científica suficiente que garantice la seguridad para el desarrollo fetal o neonatal; por lo tanto, su uso está contraindicado en mujeres embarazadas debido al riesgo potencial de efectos teratogénicos o toxicidad sistémica. Durante la lactancia, la transferencia de alcaloides a través de la leche materna puede exponer al lactante a riesgos de toxicidad neurológica o cardíaca, por lo que se recomienda evitar su consumo. Para niños menores de 12 años, el uso de extractos de Cinchona calisaya debe evitarse estrictamente, ya que sus sistemas metabólicos y fisiológicos en desarrollo no pueden procesar adecuadamente la carga de alcaloides, aumentando el riesgo de intoxicación aguda. En cuanto a las interacciones farmacológicas, la cinconina y otros alcaloides pueden interactuar peligrosamente con la warfarina, ya que pueden alterar la coagulación sanguínea y aumentar el riesgo de hemorragias. Asimismo, pueden potenciar o interferir con fármacos antihipertensivos debido a sus efectos sobre el sistema cardiovascular, y existe un riesgo de interacción con la metformina si se producen alteraciones en el metabolismo de la glucosa o la función renal.
Otras plantas estudiadas para Inflamación crónica y aguda
Perfil completo: Ver todos los usos y evidencia de Quina amarilla →