Cascarilla para Malaria y fiebres intermitentes
Cinchona cordifolia — 10 estudios científicos revisados
Strong¿Sirve Cascarilla para malaria y fiebres intermitentes?
La quinina, principal alcaloide de Cinchona, actúa interfiriendo con la capacidad del parásito Plasmodium para metabolizar la hemoglobina, acumulando hemo tóxico que destruye al parásito dentro del eritrocito.
Compuestos activos involucrados: quinina, quinidina, cinconina, cinconidina, taninos, ácido quínico, Alcaloides, Glucósidos, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Cascarilla y malaria y fiebres intermitentes:
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids.
BACKGROUND: Cinchonine is one of the Cinchona alkaloids that is commercially extracted from the Peruvian bark of Cinchona officinalis L. (Family: Rubiaceae). It is also obtained in much lower quantities from other species of Cinchona, such as Cinchona calisaya, Cinchona succirubra, and Cinchona pubescens, and in some other plants, such as Remijia peruviana. Cinchonine has been historically used as an anti-malarial agent. It also has a wide range of other biological properties, including anti-cancer, anti-obesity, anti-inflammatory, anti-parasitic, antimicrobial, anti-platelet aggregation, and
PubMed: 38031797Natural Products That Changed Society.
Until the end of the 19th century all drugs were natural products or minerals. During the 19th century chemists succeeded in isolating pure natural products such as quinine, morphine, codeine and other compounds with beneficial effects. Pure compounds enabled accurate dosing to achieve serum levels within the pharmacological window and reproducible clinical effects. During the 20th and the 21st century synthetic compounds became the major source of drugs. In spite of the impressive results achieved within the art of synthetic chemistry, natural products or modified natural products still const
PubMed: 33925870The Fever Tree: from Malaria to Neurological Diseases.
This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine. Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars. Over those 400 years, the medical use of cinchona alkaloids has evolved from bark extracts to chemical synthesis and controlled clinical trials. At the present time, the use of quinine and quinidine has declined, to a large extent due to their toxicity. However, quinine is still being pres
PubMed: 30477182Medicinal plants used in the treatment of Malaria: A key emphasis to Artemisia, Cinchona, Cryptolepis, and Tabebuia genera.
Malaria is one of the life-threatening parasitic diseases that is endemic in tropical areas. The increased prevalence of malaria due to drug resistance leads to a high incidence of mortality. Drug discovery based on natural products and secondary metabolites is considered as alternative approaches for antimalarial therapy. Herbal medicines have advantages over modern medicines, including fewer side effects, cost-effectiveness, and affordability encouraging the herbal-based drug discovery. Several naturally occurring, semisynthetic, and synthetic antimalarial medications are on the market.
PubMed: 32022345Artemisinin-hydroxychloroquine combination from traditional antimalarial medicine attenuates pulmonary fibrosis via PI3K/AKT/GSK3β-mediated inhibition of epithelial-mesenchymal transition.
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisinin and hydroxychloroquine, derived respectively from Artemisia annua L. (Qinghao) and Cinchona calisaya Wedd., have been widely used for centuries to treat malaria and inflammatory disorders. In addition to their antimalarial activity, these compounds exhibit multifunctionality, including anti-inflammatory, antifibrotic, and immunomodulatory effects. Although preliminary studies suggested that the artemisinin-hydroxychloroquine (AH) combination may attenuate idiopathic pulmonary fibrosis (IPF), its underlying mechanisms remain poorly understood. AIM OF
PubMed: 41076144Seguridad y Precauciones
El uso de preparaciones de Cinchona cordifolia requiere extrema precaución debido a la potencia de sus alcaloides, particularmente la quinina. Durante el embarazo, el uso está estrictamente contraindicado: la quinina atraviesa la barrera placentaria y puede provocar contracciones uterinas, aborto espontáneo y malformaciones congénitas del sistema auditivo del feto. Durante la lactancia, los alcaloides se excretan en la leche materna, pudiendo causar toxicidad en el lactante. En niños menores de 12 años, la administración de extractos de corteza de cinchona debe evitarse completamente debido a la dificultad de controlar la dosis de alcaloides y la mayor sensibilidad pediátrica a sus efectos tóxicos, particularmente la ototoxicidad (daño auditivo) y la cardiotoxicidad. Las interacciones farmacológicas son numerosas y potencialmente graves. La quinina y la quinidina inhiben la enzima CYP2D6 del citocromo P450, lo que puede alterar el metabolismo de antidepresivos (fluoxetina, paroxetina), betabloqueantes (metoprolol), antipsicóticos y opioides (codeína).
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