Cinchona lancifolia para Malaria (actividad antiprotozoal)
Cinchona lancifolia — 11 estudios científicos revisados
Strong¿Sirve Cinchona lancifolia para malaria (actividad antiprotozoal)?
Los alcaloides de la Cinchona, como la quinina y la cinchonina, actúan interfiriendo con la capacidad del parásito Plasmodium para procesar la hemoglobina, lo que resulta en la acumulación de metabolitos tóxicos para el parásito dentro del eritrocito [PMID 32022345].
Compuestos activos involucrados: Alcaloides, Flavonoides, Terpenos, Cinchonina, Quinolina, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Cinchona lancifolia y malaria (actividad antiprotozoal):
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids.
BACKGROUND: Cinchonine is one of the Cinchona alkaloids that is commercially extracted from the Peruvian bark of Cinchona officinalis L. (Family: Rubiaceae). It is also obtained in much lower quantities from other species of Cinchona, such as Cinchona calisaya, Cinchona succirubra, and Cinchona pubescens, and in some other plants, such as Remijia peruviana. Cinchonine has been historically used as an anti-malarial agent. It also has a wide range of other biological properties, including anti-cancer, anti-obesity, anti-inflammatory, anti-parasitic, antimicrobial, anti-platelet aggregation, and
PubMed: 38031797Natural Products That Changed Society.
Until the end of the 19th century all drugs were natural products or minerals. During the 19th century chemists succeeded in isolating pure natural products such as quinine, morphine, codeine and other compounds with beneficial effects. Pure compounds enabled accurate dosing to achieve serum levels within the pharmacological window and reproducible clinical effects. During the 20th and the 21st century synthetic compounds became the major source of drugs. In spite of the impressive results achieved within the art of synthetic chemistry, natural products or modified natural products still const
PubMed: 33925870A matter of some sensitivity.
The development of sensitive chromatographic and spectroscopic techniques for the isolation and structure determination of natural products has greatly facilitated phytochemical investigations. Chemical investigations of herbarium material have resulted in the isolation of indole, quinoline and isoquinoline alkaloids from a wide number of plants. Examples of novel natural products from higher plants are given and include alkaloids, terpenoids, phenolics and quinones. Some plants investigated have not yielded the types of constituents which would have been predicted from them. Plant tissue cult
PubMed: 7786474The Fever Tree: from Malaria to Neurological Diseases.
This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine. Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars. Over those 400 years, the medical use of cinchona alkaloids has evolved from bark extracts to chemical synthesis and controlled clinical trials. At the present time, the use of quinine and quinidine has declined, to a large extent due to their toxicity. However, quinine is still being pres
PubMed: 30477182Medicinal plants used in the treatment of Malaria: A key emphasis to Artemisia, Cinchona, Cryptolepis, and Tabebuia genera.
Malaria is one of the life-threatening parasitic diseases that is endemic in tropical areas. The increased prevalence of malaria due to drug resistance leads to a high incidence of mortality. Drug discovery based on natural products and secondary metabolites is considered as alternative approaches for antimalarial therapy. Herbal medicines have advantages over modern medicines, including fewer side effects, cost-effectiveness, and affordability encouraging the herbal-based drug discovery. Several naturally occurring, semisynthetic, and synthetic antimalarial medications are on the market.
PubMed: 32022345Seguridad y Precauciones
La seguridad en el uso de Cinchona lancifolia debe abordarse con extrema cautela debido a la presencia de alcaloides quinolínicos, los cuales poseen una ventana terapéutica estrecha. En el caso de mujeres embarazadas y en periodo de lactancia, el uso de esta planta está contraindicado o debe ser estrictamente supervisado por profesionales médicos. Los alcaloides de la familia Cinchona, como la cinchonina y la quinina, pueden atravesar la barrera placentaria y la barrera hematoencefálica, lo que representa un riesgo potencial para el desarrollo fetal y la salud del lactante. No existe evidencia suficiente que garantice la inocuidad de estos compuestos durante la gestación, por lo que se recomienda evitar su consumo para prevenir posibles efectos teratogénicos o toxicidad sistémica en el neonato. En niños menores de 12 años, su administración no está recomendada debido a la inmadurez de sus sistemas metabólicos, especialmente el hepático y el renal, lo que incrementa el riesgo de acumulación de metabolitos tóxicos. En cuanto a las interacciones farmacológicas, la Cinchona lancifolia puede interactuar peligrosamente con fármacos que afectan la coagulación, como la warfarina, debido a que ciertos alcaloides pueden alterar la agregación plaquetaria o la dinámica de la coagulación sanguínea.
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