Quina roja para antimalarial
Cinchona pubescens — 5 estudios científicos revisados
Preliminary¿Sirve Quina roja para antimalarial?
La investigación científica ha explorado el potencial de Quina roja (Cinchona pubescens) en relación con antimalarial. Se han identificado 5 estudios relevantes que examinan esta relación.
Compuestos activos involucrados: Alcaloides, Cinconidina, Cinconina, Flavonoides, Quinidina, Quinina, Saponinas
Evidencia Científica
Los siguientes estudios han investigado la relación entre Quina roja y antimalarial:
The use of an integrated molecular-, chemical- and biological-based approach for promoting the better use and conservation of medicinal species: a case study of Brazilian quinas.
ETHNOPHARMACOLOGICAL RELEVANCE: Quina is a popular name originally attributed to Cinchona pubescens Vahl (=Cinchona succirubra) and Cinchona. calisaya Wedd., species native from Peru that have the antimalarial alkaloid quinine. In Brazil, bitter barks substitutes for the Peruvian species began to be used centuries ago, and they still are sold in popular markets. To assess the authenticity and the conditions on which samples of quinas have been commercialized, using the DNA barcode, chemical and biological assays. MATERIALS AND METHODS: Starting with 28 samples of barks acquired on a popular ma
PubMed: 24971797Medicinal plants used in the treatment of Malaria: A key emphasis to Artemisia, Cinchona, Cryptolepis, and Tabebuia genera.
Malaria is one of the life-threatening parasitic diseases that is endemic in tropical areas. The increased prevalence of malaria due to drug resistance leads to a high incidence of mortality. Drug discovery based on natural products and secondary metabolites is considered as alternative approaches for antimalarial therapy. Herbal medicines have advantages over modern medicines, including fewer side effects, cost-effectiveness, and affordability encouraging the herbal-based drug discovery. Several naturally occurring, semisynthetic, and synthetic antimalarial medications are on the market.
PubMed: 32022345Artemisinin-hydroxychloroquine combination from traditional antimalarial medicine attenuates pulmonary fibrosis via PI3K/AKT/GSK3β-mediated inhibition of epithelial-mesenchymal transition.
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisinin and hydroxychloroquine, derived respectively from Artemisia annua L. (Qinghao) and Cinchona calisaya Wedd., have been widely used for centuries to treat malaria and inflammatory disorders. In addition to their antimalarial activity, these compounds exhibit multifunctionality, including anti-inflammatory, antifibrotic, and immunomodulatory effects. Although preliminary studies suggested that the artemisinin-hydroxychloroquine (AH) combination may attenuate idiopathic pulmonary fibrosis (IPF), its underlying mechanisms remain poorly understood. AIM OF
PubMed: 41076144Antiparasitic properties of medicinal plants and other naturally occurring products.
Parasitic diseases remain a major public health problem affecting hundreds of millions of people, particularly in tropical developing countries. The limited availability and affordability of pharmaceutical medicines means that the majority of the world's population depends on traditional medical remedies, and it is estimated that some 20,000 species of higher plant are used medicinally throughout the world. Many well-known drugs listed in the modern pharmacopoeia have their origins in nature, including, for example, quinine from the bark of the Cinchona tree for the treatment of malaria, which
PubMed: 11757332Analysis of complementarities between nanomedicine and phytodrugs for the treatment of malarial infection.
The use of nanocarriers in medicine, so-called nanomedicine, is one of the most innovative strategies for targeting drugs at the action site and increasing their activity index and effectiveness. Phytomedicine is the oldest traditional method used to treat human diseases and solve health problems. The recent literature on the treatment of malaria infections using nanodelivery systems and phytodrugs or supplements has been analyzed. For the first time, in the present review, a careful look at the considerable potential of nanomedicine in promoting phytotherapeutic efficacy was done, and its key
PubMed: 37955573Seguridad y Precauciones
El uso de la corteza de Quina roja (Cinchona pubescens) conlleva riesgos significativos debido a su compleja composición de alcaloides, como la quinina, la cinconina y la cinconidina. Debido a la variabilidad química reportada en mercados populares, donde la autenticidad de la especie no siempre está garantizada [PMID 24971797], la toxicidad puede ser impredecible. En el caso de mujeres embarazadas y en periodo de lactancia, el consumo está estrictamente contraindicado. Los alcaloides de la quina pueden atravesar la barrera placentaria y la barrera hematoencefálica, con el potencial de causar efectos teratogénicos o alteraciones en el desarrollo fetal. Durante la lactancia, los compuestos pueden excretarse en la leche materna, exponiendo al lactante a riesgos de toxicidad sistémica y alteraciones en el ritmo cardíaco. Para niños menores de 12 años, el uso debe evitarse por completo debido a la inmadurez de sus sistemas metabólicos para procesar alcaloides complejos, lo que aumenta el riesgo de intoxicación aguda.
Otras plantas estudiadas para antimalarial
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