Quina roja para Cáncer
Cinchona pubescens — 8 estudios científicos revisados
Preliminary¿Sirve Quina roja para cáncer?
En términos simples, esto significa que la cinconina no solo podría ayudar contra el cáncer, sino también prevenir la pérdida de densidad ósea al bloquear las células que destruyen el hueso.
Compuestos activos involucrados: Alcaloides, Cinconidina, Cinconina, Flavonoides, Quinidina, Quinina, Saponinas
Evidencia Científica
Los siguientes estudios han investigado la relación entre Quina roja y cáncer:
Green nanoarchitectonics of carbon quantum dots from Cinchona Pubescens Vahl as targeted and controlled drug cancer nanocarrier.
Carbon quantum dots (CQDs) are a new carbon-based nanomaterial that has attracted tremendous attention due to their excellent fluorescent properties, chemical stability, water solubility, and biocompatibility features. Here, fluorescent CQDs synthesized by a green nanoarchitectonic method using Cinchona Pubescens Vahl extract were evaluated as drug nanocarriers for carboplatin (CBP) delivery. The characterization methods showed CQDs with semispherical shapes and sizes around 5 nm, temperature- and pH-dependent functional groups that interact with the CBP molecule adding specificity to the drug
PubMed: 37515841Antitumor Plants. V. Constituents of Cinchona pubescens.
The stem bark and stem wood of Cinchona pubescens were found to owe their weak cytotoxic activity to the presence of quinovic acid. This acid and its 3-rhamnoside were isolated and characterized through several derivatives, all of which were assayed for their cytotoxicity.
PubMed: 713707Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination.
Hepeel is a homeopathic remedy commonly used to treat primary and secondary functional disorders of the liver. It consists of highly diluted extracts from the following plants: Chelidonium from Chelidonium majus, L., Carduus marianus from Silybum marianum, L., Veratrum from Veratrum album L., Colocynthis from Citrullus colocynthis L., Lycopodium from Lycopodium clavatum L., Nux moschata from Myristica fragans, Houtt, and China from Cinchona pubescens, Vahl. The antioxidative, antiproliferative and biochemical effects in HepG2 hepatoblastoma cells of serial dilutions of these plant tinctures we
PubMed: 14732962Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids.
BACKGROUND: Cinchonine is one of the Cinchona alkaloids that is commercially extracted from the Peruvian bark of Cinchona officinalis L. (Family: Rubiaceae). It is also obtained in much lower quantities from other species of Cinchona, such as Cinchona calisaya, Cinchona succirubra, and Cinchona pubescens, and in some other plants, such as Remijia peruviana. Cinchonine has been historically used as an anti-malarial agent. It also has a wide range of other biological properties, including anti-cancer, anti-obesity, anti-inflammatory, anti-parasitic, antimicrobial, anti-platelet aggregation, and
PubMed: 38031797Medicinal plants, human health and biodiversity: a broad review.
Biodiversity contributes significantly towards human livelihood and development and thus plays a predominant role in the well being of the global population. According to WHO reports, around 80 % of the global population still relies on botanical drugs; today several medicines owe their origin to medicinal plants. Natural substances have long served as sources of therapeutic drugs, where drugs including digitalis (from foxglove), ergotamine (from contaminated rye), quinine (from cinchona), and salicylates (willow bark) can be cited as some classical examples.Drug discovery from natural sources
PubMed: 25001990Contexto Científico
Los resultados indican que este compuesto posee propiedades anticancerígenas al activar la caspasa-3 y la proteína PARP-1, desencadenando el estrés del retículo endoplásmico en células cancerosas. En resumen, la evidencia científica actual es robusta en cuanto a la identificación de los mecanismos moleculares de sus alcaloides (como la cinconina), demostrando efectos anticancerígenos y antiinflamatorios en modelos in vitro e in vivo.
Seguridad y Precauciones
El uso de la corteza de Quina roja (Cinchona pubescens) conlleva riesgos significativos debido a su compleja composición de alcaloides, como la quinina, la cinconina y la cinconidina. Debido a la variabilidad química reportada en mercados populares, donde la autenticidad de la especie no siempre está garantizada [PMID 24971797], la toxicidad puede ser impredecible. En el caso de mujeres embarazadas y en periodo de lactancia, el consumo está estrictamente contraindicado. Los alcaloides de la quina pueden atravesar la barrera placentaria y la barrera hematoencefálica, con el potencial de causar efectos teratogénicos o alteraciones en el desarrollo fetal. Durante la lactancia, los compuestos pueden excretarse en la leche materna, exponiendo al lactante a riesgos de toxicidad sistémica y alteraciones en el ritmo cardíaco. Para niños menores de 12 años, el uso debe evitarse por completo debido a la inmadurez de sus sistemas metabólicos para procesar alcaloides complejos, lo que aumenta el riesgo de intoxicación aguda.
Otras plantas estudiadas para Cáncer
Perfil completo: Ver todos los usos y evidencia de Quina roja →