Corydalis para Inflamación sistémica
Corydalis crispa — 5 estudios científicos revisados
Strong¿Sirve Corydalis para inflamación sistémica?
Los extractos crudos de la planta han demostrado una capacidad significativa para inhibir la producción de la citoquina proinflamatoria TNF-alfa en células monocíticas, lo que ayuda a reducir la respuesta inflamatoria celular.
Compuestos activos involucrados: Acetilcolina, Alcaloides, Coreximina, Estilopina, Flavonoides, Ocrobirina, Protopina, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Corydalis y inflamación sistémica:
Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa.
The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibitedsignificant anti-inflammatory (p < 0.01) activity against TNF-alpha production in LPS activated THP-1 cells. The acetylcholinesterase inh
PubMed: 22799079Tibetan medicine Baxiaga: a systematic review of its historical herbalogical investigation, phytochemical constituents, and pharmacological activities.
BACKGROUND: Baxiaga (བ་ཤ་ཀ) is a typical Tibetan medicinal species of multiple origin. These plants have been used in traditional Tibetan medicine for centuries and are currently used to treat various types of fever, such as Chiba fever, liver fever, reduce inflammation, relieve pain, and heal other diseases. OBJECTIVE: This review aims to provide a comprehensive analysis of the traditional uses of the baxiaga series of plants ( MATERIALS AND METHODS: This review performed an extensive database search to collect detailed information about baxiaga and the literature was systematically interpret
PubMed: 41971083Defined Small Molecules Produced by Himalayan Medicinal Plants Display Immunomodulatory Properties.
Plant-derived compounds that modulate the immune responses are emerging as frontline treatment agents for cancer, infectious diseases and autoimmunity. Herein we have isolated 40 phytochemicals from five Bhutanese
PubMed: 30404196Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms.
Schistosomiasis and trichuriasis are two of the most common neglected tropical diseases (NTD) that affect almost a billion people worldwide. There is only a limited number of effective drugs to combat these NTD. Medicinal plants are a viable source of parasiticides. In this study, we have investigated six of the 19 phytochemicals isolated from two Bhutanese medicinal plants, Corydalis crispa and Pleurospermum amabile, for their anthelmintic properties. We used the xWORM technique and Scanning Electron Microscope-based imaging to determine the activity of the compounds.
PubMed: 27572696Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants.
ETHNOPHARMACOLOGICAL RELEVANCE: Seven studied medicinal plants; Aconitum laciniatum, Ajania nubigena, Codonopsis bhutanica, Corydalis crispa, Corydalis dubia, Meconopsis simplicifolia and Pleurospermum amabile, are currently used in the Bhutanese Traditional Medicine (BTM) for the management of different types of disorders including the diseases that bore relevance to various inflammatory conditions. AIMS OF THE STUDY: This study aimed to evaluate the inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven selected Bhutanese medicinal plants. It is
PubMed: 23769984Seguridad y Precauciones
El uso de Corydalis crispa debe abordarse con extrema precaución debido a su compleja composición de alcaloides isoquinolínicos, como la protopina, estilopina y bicuculina, los cuales poseen una actividad biológica potente y riesgos potenciales para la salud humana. En lo que respecta al embarazo y la lactancia, el uso de esta planta está estrictamente contraindicado. No existe evidencia clínica suficiente que garantice la seguridad en mujeres gestantes; por el contrario, la presencia de alcaloides con actividad neurotóxica y efectos sobre el desarrollo celular sugiere un riesgo de teratogenicidad (malformaciones fetales) o alteraciones en el desarrollo del feto. Durante la lactancia, los compuestos químicos pueden ser excretados a través de la leche materna, exponiendo al lactante a dosis impredecibles que podrían afectar su sistema nervioso central en desarrollo. Para niños menores de 12 años, la administración debe evitarse por completo. Los sistemas fisiológicos pediátricos son altamente sensibles a los cambios en la actividad enzimática y a la neurotoxicidad de los alcaloides, lo que aumenta el riesgo de efectos adversos graves.
Otras plantas estudiadas para Inflamación sistémica
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