Eschscholzia para Dolor leve a moderado
Eschscholzia californica — 6 estudios científicos revisados
Preliminary¿Sirve Eschscholzia para dolor leve a moderado?
Los efectos analgésicos se atribuyen a la actividad de los alcaloides sobre las vías de señalización del dolor en el sistema nervioso central.
Compuestos activos involucrados: Alcaloides, Flavonoides, Macarpina, Saponinas, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Eschscholzia y dolor leve a moderado:
Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors.
The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected in E. californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons.
PubMed: 26509084A genome assembly of the California poppy, Eschscholzia californica.
The California poppy (Eschscholzia californica), a native wildflower of western North America and the state wildflower of California, is characterized by extensive ecological variation and adaptation to diverse climatic conditions. Its broad geographic range and adaptability make it a valuable model for studying how plants respond to changing environmental conditions. Here, we present an updated, near-chromosome-level genome assembly for E. californica, developed as part of the California Conservation Genomics Project. This assembly spans 0.401 Gb and represents an advancement over previous ve
PubMed: 40874558CjbHLH1 homologs regulate sanguinarine biosynthesis in Eschscholzia californica cells.
Isoquinoline alkaloids (IQAs), terpenoid indole alkaloid and nicotine are some of the most studied alkaloids. Recently, several groups have reported that the biosynthesis of these alkaloids is regulated by basic helix-loop-helix (bHLH) transcription factors. Whereas the biosyntheses of nicotine and terpenoid indole alkaloid in Nicotiana plants and Catharanthus roseus are directly or indirectly regulated by Arabidopsis thaliana MYC2 homologs, a non-MYC2-type bHLH transcription factor, CjbHLH1, comprehensively regulates berberine biosynthesis in Coptis japonica. Interestingly, CjbHLH1 homologous
PubMed: 25713177Methods for regeneration and transformation in Eschscholzia californica: A model plant to investigate alkaloid biosynthesis.
Eschscholzia californica Cham. (California poppy) is a plant species that accumulates pharmacologically active alkaloids biosynthetically related to the morphinan alkaloids of Papaver somniferum. This, in combination with the relative ease with which it is propagated in vitro, makes it a key model for benzylisoquinoline biosynthesis. Transformation techniques are an important tool for these studies and for metabolic engineering attempts. Agrobacterium mediated transformation techniques for this model species have been developed in our lab and used for modulation of transcript levels relevant t
PubMed: 16673930Genome-wide identification of AP2/ERF transcription factor-encoding genes in California poppy (Eschscholzia californica) and their expression profiles in response to methyl jasmonate.
With respect to the biosynthesis of plant alkaloids, that of benzylisoquinoline alkaloids (BIAs) has been the most investigated at the molecular level. Previous investigations have shown that the biosynthesis of BIAs is comprehensively regulated by WRKY and bHLH transcription factors, while promoter analyses of biosynthesis enzyme-encoding genes have also implicated the involvement of members of the APETALA2/ethylene responsive factor (AP2/ERF) superfamily. To investigate the physiological roles of AP2/ERF transcription factors in BIA biosynthesis, 134 AP2/ERF genes were annotated using the dr
PubMed: 33093564Seguridad y Precauciones
El uso de Eschscholzia californica debe abordarse con extrema cautela debido a su perfil farmacológico centrado en la modulación del sistema nervioso central. En lo que respecta al embarazo y la lactancia, no existe evidencia clínica suficiente que garantice la seguridad del consumo de esta planta; por el contrario, debido a su capacidad para actuar sobre los receptores GABA (ácido gamma-aminobutírico), existe un riesgo teórico de efectos sedantes o de interferencia con el desarrollo neurológico fetal. El GABA es un neurotransmisor inhibidor fundamental para el desarrollo cerebral, y la presencia de alcaloides como la (S)-reticulina, que actúa como modulador alostérico positivo en isoformas específicas de los receptores GABA-A (como α3, α5 y α6), podría alterar la señalización neuronal en el feto o en el lactante. Por tanto, se desaconseja su uso en estas etapas. Para niños menores de 12 años, la seguridad es desconocida y el riesgo de sedación profunda o depresión respiratoria es significativamente mayor debido a la inmadurez de su sistema nervioso. En cuanto a las interacciones farmacológicas, la planta presenta riesgos críticos con medicamentos depresores del sistema nervioso central (como benzodiacepinas o alcohol), ya que sus alcaloides podrían potenciar de forma impredecible los efectos sedantes.
Perfil completo: Ver todos los usos y evidencia de Eschscholzia →