Lapacho rosado para Cáncer (diversos tipos)
Handroanthus heptaphyllus — 4 estudios científicos revisados
In_vitro¿Sirve Lapacho rosado para cáncer (diversos tipos)?
Una fracción polisacarídica de las hojas, compuesta por arabinananos y galactanos, mostró actividad gastroprotectora significativa en modelos animales [PMID 31582051].
Compuestos activos involucrados: lapachol, β-lapachona, furanonaftoquinonas, ácido ursólico, quercetina, rutina, Flavonoides, Naftoquinona, Taninos, Topoisomerasa, Naftoquinonas
Evidencia Científica
Los siguientes estudios han investigado la relación entre Lapacho rosado y cáncer (diversos tipos):
Polysaccharide fractions from Handroanthus heptaphyllus and Handroanthus albus barks: Structural characterization and cytotoxic activity.
Barks of trees of the genus Handroanthus are known for their antitumor activity, which is attributed to naphthoquinones. Another class of molecules that has shown antitumor activity are the polysaccharides, however those from Handroanthus barks have never been studied. Accordingly, the aim of this study was to extract polysaccharides from H. heptaphyllus and H. albus barks, to characterize them structurally and to evaluate their cytotoxic effects on the human colon and human breast cancer cell lines, Caco-2 and MCF-7, respectively.
PubMed: 33010272Understanding the optimal temperature range for foliar development of neotropical forest species during the seedling stage.
Thermal requirements is a tool to predict plant leaf development. This study aimed to estimate the cardinal temperatures and phyllochron for the foliar development of seedlings from four neotropical forest species native to Brazilian biomes. An experiment was conducted using various sowing dates to provide a wide range of temperature regimes, to estimate the base (Tb), optimum (Topt), and maximum (TB) temperature and phyllochron of Handroanthus heptaphyllus, Tabebuia roseoalba, Ceiba speciosa, and Schinus terebinthifolia. The results indicated significant variations in the cardinal temperature
PubMed: 41483029Anticancer potential and toxicity of the genus Handroanthus Mattos (Bignoniaceae): A systematic review.
The genus Handroanthus Mattos (Bignoniaceae) is widely used for the treatment of cancer in traditional medicine in Brazil and other South American countries. The anticancer potential of species of this genus has been reported in the literature, indicating that their chemical compounds may be effective against different tumor cell lines. In this perspective, the present study aimed to conduct a systematic review of ethnobotanical, pharmacological, phytochemical and toxicological information on Handroanthus species related to cancer treatment. Searches were conducted in the Google Scholar, PubMe
PubMed: 35998713Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis.
β-Lapachone is an ortho-naphthoquinone originally isolated from the heartwood of Handroanthus impetiginosus and can be obtained through synthesis from lapachol, naphthoquinones, and other aromatic compounds. β-Lapachone is well known to inhibit topoisomerase I and to induce NAD(P)H: quinone oxidoreductase 1. Currently, phase II clinical trials are being conducted for the treatment of pancreatic cancer. In view of ever-increasing scientific interest in this naphthoquinone, herein, the authors present a review of the synthesis, physicochemical properties, biological activities, and toxicity of β
PubMed: 33667813Seguridad y Precauciones
En el análisis de seguridad del Lapacho rosado (Handroanthus heptaphyllus), es imperativo señalar que la evidencia científica disponible en humanos es limitada y se basa predominantemente en estudios preclínicos, lo que exige una gestión de riesgos extremadamente cautelosa. Respecto al embarazo y la lactancia, el uso de esta planta está estrictamente desaconsejado; la presencia de naftoquinonas, como el lapachol y la beta-lapachona, plantea un riesgo de citotoxicidad debido a su capacidad para generar especies reactivas de oxígeno (ROS), lo que podría interferir con la división celular normal y derivar en efectos teratogénicos durante el desarrollo embrionario. En la lactancia, la transferencia de metabolitos activos a través de la leche materna no ha sido estudiada, por lo que el riesgo de toxicidad sistémica en el lactante es una preocupación válida y no se debe asumir la inocuidad. Para niños menores de 12 años, el uso es contraindicado debido a la inmadurez de sus sistemas enzimáticos hepáticos, específicamente del complejo citocromo P450, lo que dificulta la metabolización segura de compuestos complejos. En cuanto a las interacciones farmacológicas, el consumo de Lapacho puede potenciar el efecto de la warfarina, incrementando el riesgo de hemorragias debido a la posible alteración de la agregación plaquetaria o la cascada de coagulación. Con la metformina, existe una preocupación teórica sobre la alteración de la homeostasis de la glucosa, lo que podría desestabilizar los niveles de glucemia.
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