Hypericum para Reducción de la eficacia de fármacos (Interacción farmacocinética)
Hypericum nummularium — 4 estudios científicos revisados
Strong¿Sirve Hypericum para reducción de la eficacia de fármacos (interacción farmacocinética)?
La inducción de las enzimas del citocromo P450 acelera el metabolismo de medicamentos, reduciendo su concentración en el torrente sanguíneo.
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y reducción de la eficacia de fármacos (interacción farmacocinética):
Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228Adverse effects of herbal medicines: an overview of systematic reviews.
This overview of systematic reviews (SRs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (HMs). Five electronic databases were searched to identify all relevant SRs, with 50 SRs of 50 different HMs meeting our inclusion criteria. Most had only minor weaknesses in methods. Serious adverse effects were noted only for four HMs: Herbae pulvis standardisatus, Larrea tridentate, Piper methysticum and Cassia senna. The most severe adverse effects were liver or kidney damage, colon perforation, carcinoma, coma and death.
PubMed: 23472485Ethnobotanical and ethnomedicinal research into medicinal plants in the Mt Stara Planina region (south-eastern Serbia, Western Balkans).
BACKGROUND: Ethnobotanical research in Southeast Europe-one of the most important European hotspots for biocultural diversity-is significant for the acquisition of Traditional Ecological Knowledge related to plants as well as for encouraging the development of local environments. The current ethnobotanical research was conducted in the region of Mt Stara Planina (south-eastern Serbia), which is characterised by rich phytodiversity with a large number of endemic and relict plant species. The aim of the study was to document the diversity of uses of medicinal plants and of traditional knowledge
PubMed: 38200599Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression.
PubMed: 39598400Seguridad y Precauciones
El uso de especies del género Hypericum, particularmente aquellas con propiedades farmacológicas activas como Hypericum perforatum (frecuentemente estudiada en relación con Hypericum nummularium), requiere una vigilancia extrema debido a su capacidad para alterar el metabolismo de fármacos esenciales. En el contexto de **embarazo y lactancia**, no existe evidencia suficiente que garantice la seguridad del uso de estas plantas; por el contrario, existe un riesgo potencial de efectos teratogénicos o alteraciones en el desarrollo fetal debido a su actividad biológica sobre el sistema nervioso central. Durante la lactancia, los compuestos activos pueden ser excretados en la leche materna, lo que podría exponer al lactante a concentraciones sistémicas no controladas, afectando su desarrollo neurológico. El uso en estas etapas debe evitarse a menos que exista una supervisión médica estricta y una evaluación de riesgo-beneficio exhaustiva. En **niños menores de 12 años**, el uso de Hypericum no está recomendado. El sistema enzimático hepático y la barrera hematoencefálica de los infantes y niños pequeños están en constante desarrollo, lo que los hace particularmente vulnerables a las interacciones farmacocinéticas.
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