Hypericum para Interacción farmacocinética
Hypericum thymbrifolium — 5 estudios científicos revisados
Moderate¿Sirve Hypericum para interacción farmacocinética?
A través de la inducción de enzimas como el citocromo P450, la planta puede alterar la velocidad con la que el cuerpo procesa medicamentos sintéticos, reduciendo su efectividad.
Compuestos activos involucrados: {'name': 'Germacreno D', 'class': 'Sesquiterpeno'}, {'name': 'Hiperforina', 'class': 'Floroglucinol'}, {'name': 'Quercetina', 'class': 'Flavonoide'}
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y interacción farmacocinética:
Investigation of the effects of mineral elements on flower coloration of plants growing in different habitats (limestone, serpentine, gypsum).
In this study, 25 plant species growing in different habitats in Erzincan province were studied with gypsum (Ebenus macrophylla, Gypsophila lepidioides, Linum flavum, Onobrychis nitida, Paracaryum stenolophum, Psephellus recepii, Tanacetum heterotomum, Verbascum alyssifolium), limestone (Alkanna megacarpa, Alyssum sibiricum, Anthemis sp., Astragalus sp., Chrysophthalmum montanum, Ebenus laguroides, Genista aucheri, Pelargonium endlicherianum, Stachys sparsipilosa), or serpentine (Artedia squamata, Consolida olopetala, Convolvulus pseudoscammania, Erysimum pulchellum, Fumana aciphylla, Gladiolu
PubMed: 37975999Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228Adverse effects of herbal medicines: an overview of systematic reviews.
This overview of systematic reviews (SRs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (HMs). Five electronic databases were searched to identify all relevant SRs, with 50 SRs of 50 different HMs meeting our inclusion criteria. Most had only minor weaknesses in methods. Serious adverse effects were noted only for four HMs: Herbae pulvis standardisatus, Larrea tridentate, Piper methysticum and Cassia senna. The most severe adverse effects were liver or kidney damage, colon perforation, carcinoma, coma and death.
PubMed: 23472485Ethnobotanical and ethnomedicinal research into medicinal plants in the Mt Stara Planina region (south-eastern Serbia, Western Balkans).
BACKGROUND: Ethnobotanical research in Southeast Europe-one of the most important European hotspots for biocultural diversity-is significant for the acquisition of Traditional Ecological Knowledge related to plants as well as for encouraging the development of local environments. The current ethnobotanical research was conducted in the region of Mt Stara Planina (south-eastern Serbia), which is characterised by rich phytodiversity with a large number of endemic and relict plant species. The aim of the study was to document the diversity of uses of medicinal plants and of traditional knowledge
PubMed: 38200599Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression.
PubMed: 39598400Seguridad y Precauciones
El uso de Hypericum thymbrifolium requiere una vigilancia extrema debido a su estrecha relación filogenética con Hypericum perforatum, el cual posee un perfil de interacciones farmacológicas altamente complejo. En el caso de mujeres embarazadas o en periodo de lactancia, no existe evidencia clínica suficiente que garantice la seguridad del consumo de esta planta; por lo tanto, su uso está contraindicado. El riesgo radica en la capacidad de los compuestos fitoquímicos para atravesar la barrera placentaria o ser excretados a través de la leche materna, lo que podría exponer al feto o al lactante a efectos neurovegetativos impredecibles. Para niños menores de 12 años, la seguridad es igualmente incierta, ya que los sistemas metabólicos y enzimáticos en desarrollo son altamente sensibles a la inducción de vías de detoxificación, lo que podría alterar el metabolismo de otros fármacos esenciales para su crecimiento. En cuanto a las interacciones farmacológicas, el mecanismo principal es la inducción de las enzimas del citocromo P450 (específicamente la isoenzima CYP3A4) y la glicoproteína P. Esto significa que la planta puede acelerar la degradación de medicamentos, reduciendo su concentración en sangre a niveles sub-terapéuticos.
Perfil completo: Ver todos los usos y evidencia de Hypericum →