Kielmeyera para Infecciones bacterianas (específicamente por Staphylococcus aureus)
Kielmeyera variabilis — 6 estudios científicos revisados
Moderate¿Sirve Kielmeyera para infecciones bacterianas (específicamente por staphylococcus aureus)?
La presencia de xantonas y acilporoglucinolidos en los extractos de la planta muestra actividad antibacteriana al inhibir el crecimiento de cepas como S. aureus, interfiriendo con la viabilidad celular bacteriana.
Compuestos activos involucrados: Xantonas, Flavonoides, Esteroles, β-Sitosterol, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Kielmeyera y infecciones bacterianas (específicamente por staphylococcus aureus):
Antibacterial xanthones from Kielmeyera variabilis mart. (Clusiaceae).
The bioassay-guided fractionation of stems from Kielmeyera variabilis, traditionally used in Brazilian folk medicine, yielded assiguxanthone-B (1), kielcorin (4), 2,5-dihydroxybenzoic acid (3), and a mixture of xanthones containing assiguxanthone-B (1) and 1,3,5,6-tetrahydroxy-2-prenylxanthone (2) (1:1 w/w). The xanthone mixture inhibited Staphylococcus aureus and Bacillus subtilis at a concentration of 6.25 g/ml. When tested alone, the minimal inhibitory concentration of assiguxanthone-B was 25 g/ml against B. subtilis. Kielcorin and 2,5-dihydroxybenzoic acid were inactive against both strain
PubMed: 12937772Biological activities of extracts from Chenopodium ambrosioides Lineu and Kielmeyera neglecta Saddi.
BACKGROUND: Chenopodium ambrosioides and Kielmeyera neglecta are plants traditionally used in Brazil to treat various infectious diseases. The study of the biological activities of these plants is of great importance for the detection of biologically active compounds. METHODS: Extracts from these plants were extracted with hexane (Hex), dichloromethane (DCM), ethyl acetate (EtOAc) and ethanol (EtOH) and assessed for their antimicrobial properties, bioactivity against Artemia salina Leach and antifungal action on the cell wall of Neurospora crassa. RESULTS: Extracts from C. ambrosioides (Hex, D
PubMed: 22839690Free radical scavenging activity of Kielmeyera variabilis (Clusiaceae).
As part of our ongoing research on antioxidant agents from Brazilian flora, we screened the free radical scavenging activity of two extracts and eight fractions of Kielmeyera variabilis (Clusiaceae) using DPPH· (2,2-diphenyl-1-picrylhydrazyl-hydrate) and ABTS·+ [2,2'-azinobis(3-ethylenebenzothiazoline-6-sulfonic acid)] colorimetric assays. The ethyl acetate and n-butanol fractions of the leaves of K. variabilis displayed the strongest activity (IC₅₀ of 3.5 ± 0.3 and 4.4 ± 0.2 μg mL⁻¹ for DPPH· and 6.6 ± 0.4 and 3.1 ± 0.1 μg mL⁻¹ for ABTS·+, respectively). Chromatographic fractionation of the m
PubMed: 23429348Antiproliferative Constituents of Geopropolis from the Bee Melipona scutellaris.
Fractionation of geopropolis from Melipona scutellaris, guided by antiproliferative activity against two colon cancer cell lines (COLO205 and KM12), led to the isolation of two new cinnamic acid esters, mammea-type coumarins 5,7-dihydroxy-6-(3-methyl-2-butenyl)-8-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-propyl-coumarin (1) and 5,7-dihydroxy-6-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-phenylcoumarin (2), along with five known coumarins, mammeigin (3), hydroxymammeigin (4), mammeisin (5), cinnamoyloxy-mammeisin (6), and mammein (7), and the prenylated benzophenone ent-nemorosone (8). Among the isolated com
PubMed: 26544117Preliminary toxicity study of dichloromethane extract of Kielmeyera coriacea stems in mice and rats.
Kielmeyera coriacea Mart. (Clusiaceae), known as "Pau Santo" or "Saco de Boi" in the central Brazilian plateau region, is used to treat several tropical diseases. The present study evaluated the toxic effects of dichloromethane (DcM) extract of Kielmeyera coriacea stems, administered to rodents. In the acute toxicity tests, mice receiving doses of this extract by the oral and intraperitoneal routes, showed reversible effects, with LD50 values of 1503.0 and 538.8 mg/kg, respectively. In the repeated-dose oral (90 days) toxicity tests, male and female Wistar rats were treated by gavage with diff
PubMed: 17997061Seguridad y Precauciones
El uso de Kielmeyera variabilis debe abordarse con extrema precaución debido a la ausencia de ensayos clínicos extensos en humanos que validen su seguridad a largo plazo. En el caso de mujeres embarazadas y en periodo de lactancia, el uso de esta planta está estrictamente contraindicado. No existen datos científicos que garanticen que los compuestos prenilados o las xantonas presentes en la planta no crucen la barrera placentaria o no se secreten en la leche materna, lo que podría interferir con el desarrollo fetal o neonatal. Dado que ciertos componentes han mostrado actividad citotóxica en líneas celulares (como se observa en estudios de compuestos similares en la familia), existe un riesgo teórico de teratogenicidad (malformaciones congénitas). Para niños menores de 12 años, la seguridad es totalmente desconocida; sus sistemas metabólicos y renales están en desarrollo, lo que los hace más susceptibles a la toxicidad por metabolitos secundarios que en adultos. En cuanto a interacciones farmacológicas, el potencial antioxidante y la presencia de flavonoles podrían interferir con la cinética de fármacos procesados por el citocromo P450 en el hígado.
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