Barbasco para Exceso de poblaciones de peces (control biológico)
Lonchocarpus utilis — 7 estudios científicos revisados
Strong¿Sirve Barbasco para exceso de poblaciones de peces (control biológico)?
Efecto piscicida debido a la inhibición del complejo I mitocondrial.
Compuestos activos involucrados: Cuberesina, Deguelina, Insecticida, Rotenolona, Rotenona, Tefrosina
Evidencia Científica
Los siguientes estudios han investigado la relación entre Barbasco y exceso de poblaciones de peces (control biológico):
Cubé resin insecticide: identification and biological activity of 29 rotenoid constituents.
Cubé resin, the root extract from Lonchocarpus utilis and urucu, is an important insecticide, acaricide, and piscicide. The four major active ingredients are rotenone, deguelin, rotenolone, and tephrosin, totaling 77 wt %. As a commercial pesticide, the minor constituents are also of chemical interest and toxicological relevance. This study identifies 25 minor rotenoids in cubé resin "brittle" of which 12 are new compounds, the most unusual being 7'-chloro-5'-hydroxy-4',5'-dihydrodeguelin (the first chlororotenoid from a plant extract) and four isomers of 4',5'-dihydro-4', 5'-dihydroxytephrosi
PubMed: 10552508Rotenone: from modelling to implication in Parkinson's disease.
Rotenone ([2R-(2α,6aα,12aα)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyran[3,4-b]furo [2,3-h][1]benzopyran-6(6aH)-one) is a naturally occurring compound derived from the roots and stems of Derris, Tephrosia, Lonchocarpus and Mundulea plant species. Since its discovery at the end of the 19th century, rotenone has been widely used as a pesticide for controlling insects, ticks and lice, and as a piscicide for management of nuisance fish in lakes and reservoirs. In 2000, Betarbet et al. reproduced most of the behavioural, biochemical and pathological features of Parkinson's
PubMed: 32337944Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update.
Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceral-type leishmaniasis are recorded and 60000 persons died from the disease. In Mexico, cutaneous leishmaniasis is known as chiclero's ulcer and is reported in 22 states, it is considered as a health problem. For its treatment, pentavalent antimonial drugs are administered. These drugs cause severe side effects, are costly.
PubMed: 29268964Pharmacological basis and new insights of deguelin concerning its anticancer effects.
Deguelin is a rotenoid of the flavonoid family, which can be extracted from Lonchocarpus, Derris, or Tephrosia. It possesses the inhibition of cancer cell proliferation by inducing apoptosis through regulating the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, the NF-κB signaling pathway, the Wnt signaling pathway, the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway and epidermal growth factor receptor (EGFR) signaling, activating the p38 mitogen-activated protein kinase (MAPK) pathway, repression of Bmi1, targeting cyclooxygenase-2
PubMed: 34644595Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production.
In this study, we tested the potential use of a lectin from Lonchocarpus sericeus seeds (LSL), to control neutrophil migration and inflammatory hypernociception (decrease of nociceptive threshold). Pretreatment of the animals intravenously (15 min before) with LSL inhibited neutrophil migration to the peritoneal cavity in a dose-dependent fashion confirmed by an inhibition of rolling and adhesion of leukocytes by intravital microscopy. We also tested the ability of the pretreatment with LSL to inhibit neutrophil migration on immunised mice, and it was observed that a strong inhibition of neutr
PubMed: 17466916Seguridad y Precauciones
SEGURIDAD Y PRECAUCIONES: BARBASCO (Lonchocarpus utilis) El uso de *Lonchocarpus utilis*, conocido comúnmente como Barbasco, requiere una precaución extrema debido a la presencia de compuestos químicos altamente potentes, principalmente la rotenona y la deguelina. Estos componentes, presentes en la resina de cubé extraída de sus raíces, actúan como potentes inhibidores del complejo uno (NADH:ubiquinona oxidoreductasa) en la cadena de transporte de electrones mitocondrial [PMID 15540952]. Debido a esta actividad bioquímica, el manejo de la planta debe realizarse con rigor para evitar la exposición accidental. En cuanto a la toxicidad, se debe considerar que los componentes activos de la planta son conocidos por su capacidad para inducir efectos neurotóxicos. En modelos experimentales, la administración de sustancias como la deguelina ha demostrado la capacidad de inducir síndromes similares a la enfermedad de Parkinson [PMID 15540952]. Por lo tanto, la neurotoxicidad es un riesgo latente que exige vigilancia constante.
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