Melastoma aspera para Tos y afecciones respiratorias
Melastoma aspera — 4 estudios científicos revisados
Moderate¿Sirve Melastoma aspera para tos y afecciones respiratorias?
Estudios analíticos han confirmado la presencia de Compuestos fenólicos, Polifenoles, Terpenos mediante técnicas cromatográficas y espectroscópicas, contribuyendo a la comprensión del perfil...
Compuestos activos involucrados: Flavonoides, Kaempferol, Terpenos, Fenoles, Polifenoles, Taninos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Melastoma aspera y tos y afecciones respiratorias:
DIREN mitigates DSS-induced colitis in mice and attenuates collagen deposition via inhibiting the Wnt/β-catenin and focal adhesion pathways.
BACKGROUND: DIREN is a SHE ethnic medicine with stasis-resolving, hemostasis, clearing heat, and removing toxin effects. It is clinically used in the treatment of gastrointestinal bleeding, such as ulcerative colitis (UC). AIM OF THE STUDY: Fibrosis is one of the pathological changes in the progression of UC, which can make it challenging to respond to a treatment. We aimed to illuminate the role of DIREN in DSS-induced UC and tried to unveil its related mechanisms from two perspectives: intestinal inflammation and collagen deposition. MATERIALS AND METHODS: A 2.5 % dextran sulfate sodium (DSS
PubMed: 38678963Melastoma dodecandrum polysaccharide alleviates allergic rhinitis in mice through modulating NLRP3 and IL-17 axis.
Allergic rhinitis (AR) is a prevalent nasal disorder characterized by chronic inflammation and hypersensitivity, with limited effective treatments. Melastoma dodecandrum polysaccharide (MDP), derived from a medicinal herb, exhibits anti-inflammatory and immunomodulatory properties, making it a potential therapeutic candidate for AR. This study evaluated the therapeutic efficacy of MDP in AR mice and explored its underlying mechanisms. An ovalbumin (OVA)-induced AR mouse model was established, with MDP administered via gavage or inhalation. MDP reduced sneezing and nasal scratching in AR mice.
PubMed: 40489908The anticancer activity and mechanisms of She medicine herbs.
She Medicine, a traditional therapeutic system from China's She ethnic group, shows promise in cancer treatment. This paper provides a comprehensive review of She medicinal herbs, focusing on their anticancer activities and underlying mechanisms. Compared to widely studied traditional medicines (e.g., Traditional Chinese Medicine), She Medicine exhibits unique ethnopharmacological traits, such as localized plant usage and multi-target mechanisms involving apoptosis induction, immune modulation, and tumor microenvironment regulation. Key herbs like
PubMed: 40746719Structure of a polysaccharide MDP2-1 from Melastoma dodecandrum Lour. and its anti-inflammatory effects.
The anti-inflammatory activity of polysaccharides derived from Melastoma dodecandrum Lour. was evaluated in pyretic mice and HEK-Blue™ hTLR4 cells. The testing led to the identification of MDP2-1, which was then investigated for its structural characteristics and anti-inflammatory effects. Results showed that MDP2-1 had a molecular weight of 29.234 kDa and primarily consisted of galactose, arabinose, rhamnose, glucose, glucuronic acid, and galacturonic acid. Its main backbone was composed of →4)-α-D-GalpA-(1→, →2)-α-L-Rhap-(1→, →3,4)-α-D-GalpA-(1→, →2,4)-α-D-GlcpA-(1→, and its side chains were
PubMed: 38521298Seguridad y Precauciones
La seguridad del uso de Melastoma aspera en humanos es un área con una brecha significativa de evidencia clínica, lo que impide establecer protocolos de uso seguro y estandarizado. En mujeres embarazadas y en periodo de lactancia, el riesgo es incierto y potencialmente alto; no existen estudios que confirmen la seguridad de sus metabolitos secundarios (compuestos químicos producidos por la planta, como flavonoides y taninos) respecto a su capacidad de cruzar la barrera placentaria o excretarse en la leche materna, lo que podría afectar el desarrollo del feto o la microbiota del lactante. Para niños menores de 12 años, el uso es desaconsejado debido a la inmadurez de sus sistemas enzimáticos y la sensibilidad de su mucosa gástrica ante los agentes astringentes, que son sustancias que causan la sensación de sequedad por la precipitación de proteínas en los tejidos. Respecto a las interacciones farmacológicas, la planta puede interactuar con la warfarina (anticoagulante) al interferir con la absorción intestinal o la cascada de coagulación, elevando el riesgo de hemorragias. Con la metformina (hipoglucemiante), existe el riesgo de hipoglucemia severa por un posible efecto sinérgico en el control de la glucosa sanguínea. Con los antihipertensivos, puede potenciar la reducción de la presión arterial provocando hipotensión.
Otras plantas estudiadas para Tos y afecciones respiratorias
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