Menispermum canadense para Cáncer de pulmón (NSCLC)
Menispermum canadense — 5 estudios científicos revisados
Moderate¿Sirve Menispermum canadense para cáncer de pulmón (nsclc)?
La dauricina puede superar la resistencia al osimertinib mediante la inducción de ferroptosis vía estabilización de SAT1.
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Menispermum canadense y cáncer de pulmón (nsclc):
Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1.
Osimertinib is a third-generation EGFR tyrosine kinase inhibitor (TKI) widely used to treat advanced nonsmall cell lung cancer (NSCLC) with EGFR mutations. However, resistance to osimertinib frequently develops, limiting its long-term effectiveness. In this study, we used osimertinib-resistant lung cancer cell lines and lung cancer patient-derived organoids to demonstrate the potential of dauricine, a bioactive compound derived from menispermum dauricum, to overcome osimertinib resistance in lung cancer cells. Mechanistic studies reveal that dauricine, when combined with osimertinib, efficient
PubMed: 40485050Dauricine: Review of Pharmacological Activity.
BACKGROUND: Dauricine is an important natural organic compound in PURPOSE: The purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of dauricine in recent years. METHODS: Web of Science (121 articles) and PubMed databases (97 articles) were used to search for articles related to "dauricine" published from 2000 to 2024. Meanwhile, we classified the pharmacological activity of dauricine by screening these articles. RESULTS: Emerging evidence suggests that dauricine possesses numerous pharmacological activities, including neuropro
PubMed: 39355570Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis.
Lung cancer, one of the most prevalent tumors, remains a clinical challenge with a poor five-year survival rate. Daurisoline, a bis-benzylisoquinoline alkaloid derived from the traditional Chinese herb Menispermum dauricum, is known to suppress tumor growth effectively. However, its precise mechanism of action remains unclear. In this study, we demonstrate that Daurisoline targets glycolysis and reduces the protein level of HK2, thereby inhibiting lung cancer progression. Mechanistic investigations reveal that Daurisoline directly binds to AKT and antagonizes the AKT-GSK3β-c-Myc-HK2 signaling
PubMed: 39699276Daurisoline inhibits pancreatic cancer progression by direct binding to PPARα and blocking its ubiquitination-mediated degradation.
BACKGROUND: Pancreatic cancer (PC) is well known for its high lethality, and limited therapeutic options are currently available. Daurisoline (DAU), a bisbenzylisoquinoline alkaloid isolated from Menispermum dauricum DC., has demonstrated antitumor effects in several cancers, although its precise mechanism of action remains unclear. PURPOSE: This study evaluated the DAU-mediated inhibition of pancreatic cancer and the mechanisms responsible. METHODS: DAU's inhibitory effects on PC cells were measured through EdU, CCK-8, wound healing, Transwell, and flow cytometry assays. Bioinformatics analys
PubMed: 40975039Oxoisoaporphine Alkaloids: Prospective Anti-Alzheimer's Disease, Anticancer, and Antidepressant Agents.
Oxoisoaporphine alkaloids are a family of oxoisoquinoline-derived alkaloids that were first isolated from the rhizome of Menispermum dauricum DC. (Menispermaceae). It has been demonstrated that oxoisoaporphine alkaloids possess various biological properties, such as cholinesterase and β-amyloid inhibition, acting as a topoisomerase intercalator, monoamine oxidase A inhibition, and are expected to become anti-Alzheimer's disease, anticancer, and antidepressant drugs. This review provides an overview of natural sources, synthetic routes, bioactivities, structure-function relationship, and modifi
PubMed: 29696800Seguridad y Precauciones
Seguridad (Menispermum canadense) Advertencia general: El uso de Menispermum canadense debe ser manejado con extrema precaución debido a la presencia de alcaloides complejos en su composición química. La falta de estudios clínicos extensos en humanos limita la determinación de perfiles de seguridad definitivos, por lo que se recomienda evitar su uso sin supervisión profesional. Embarazo y lactancia: No se dispone de evidencia científica que garantice la seguridad de esta planta durante la gestación o el periodo de lactancia. Debido a la presencia de alcaloides de la familia Menispermaceae, que pueden atravesar la barrera placentaria o excretarse en la leche materna, su uso está contraindicado en estas etapas para prevenir posibles efectos teratogénicos o toxicidad en el lactante. Niños: El uso en población pediátrica está estrictamente desaconsejado. Los sistemas metabólicos de los niños son más sensibles a la acción de alcaloides y compuestos biohalogenados, lo que podría derivar en toxicidad sistémica.
Perfil completo: Ver todos los usos y evidencia de Menispermum canadense →