Panax para Disfunción cardíaca (insuficiencia)
Panax quinquefolius — 7 estudios científicos revisados
Moderate¿Sirve Panax para disfunción cardíaca (insuficiencia)?
Las saponinas de Panax quinquefolius (PQS) han mostrado potencial para mejorar la fracción de eyección del ventrículo izquierdo (LVEF) y la tolerancia al ejercicio, ayudando a la función mecánica del corazón.
Compuestos activos involucrados: Flavonoides, Saponinas, Terpenos, Ginsenósidos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Panax y disfunción cardíaca (insuficiencia):
Ginseng as a Treatment for Fatigue: A Systematic Review.
BACKGROUND: Millions of people with chronic illness suffer from fatigue. Fatigue is a complex, multidimensional symptom with poorly understood causes, wide variations in severity among individuals, and negative effects on multiple domains of daily life. Many patients with fatigue report the use of herbal remedies. Ginseng is one of the most widely used because it is believed to improve energy, physical and emotional health, and well-being. OBJECTIVE: To systematically review the published evidence to evaluate the safety and effectiveness of the two types of Panax ginseng (Asian [Panax ginseng]
PubMed: 29624410The efficacy and safety of panax quinquefolius saponin for heart failure: a systematic review and meta-analysis.
BACKGROUND: Heart failure (HF) is a global health concern, affecting millions of individuals worldwide and leading to significant morbidity and mortality. Despite advances in conventional therapeutic strategies, the prognosis for HF patients remains challenging, and there is a constant search for novel therapeutic options. Among these, Panax quinquefolius saponin (PQS) has demonstrated promising pharmacological properties that may benefit HF. However, the efficacy and safety of PQS for HF have not been comprehensively evaluated. OBJECTIVE: This systematic review and meta-analysis aim to provid
PubMed: 40093323Panax quinquefolius saponins and panax notoginseng saponins attenuate myocardial hypoxia-reoxygenation injury by reducing excessive mitophagy.
OBJECTIVE: Panax quinquefolius saponins (PQS) and Panax notoginseng saponins (PNS) are key bioactive compounds in Panax quinquefolius L. and Panax notoginseng, commonly used in the treatment of clinical ischemic heart disease. However, their potential in mitigating myocardial ischemia-reperfusion injury remains uncertain. This study aims to evaluate the protective effects of combined PQS and PNS administration in myocardial hypoxia/reoxygenation (H/R) injury and explore the underlying mechanisms. METHODS: To investigate the involvement of HIF-1α/BNIP3 mitophagy pathway in the myocardial protec
PubMed: 38713401Panax quinquefolius saponin inhibits vascular smooth muscle cell calcification via activation of nuclear factor-erythroid 2-related factor 2.
BACKGROUND: Panax quinquefolius saponin (PQS) is the main active component of Panax quinquefolius. Emerging evidence suggests that PQS exerts beneficial effects against cardiovascular diseases. However, the role and mechanism of PQS in vascular calcification are not unclear. The present study investigated the effects of PQS on the calcification of vascular smooth muscle cell (VSMCs). METHODS: The present study used calcification medium containing 3 mM inorganic phosphate (Pi) to induce rat VSMCs calcification.
PubMed: 37085826Panax quinquefolius saponins combined with dual antiplatelet therapy enhanced platelet inhibition with alleviated gastric injury via regulating eicosanoids metabolism.
BACKGROUND: Panax quinquefolius saponin (PQS) was shown beneficial against platelet adhesion and for gastroprotection. This study aimed to investigate the integrated efficacy of PQS with dual antiplatelet therapy (DAPT) on platelet aggregation, myocardial infarction (MI) expansion and gastric injury in a rat model of acute MI (AMI) and to explore the mechanism regarding arachidonic acid (AA)-derived eicosanoids metabolism. METHODS: Wistar rats were subjected to left coronary artery occlusion to induce AMI model followed by treatment with DAPT, PQS or the combined therapy. Platelet aggregation
PubMed: 37596586Seguridad y Precauciones
La seguridad de Panax quinquefolius (ginseng americano) es un tema de relevancia clínica debido a su actividad farmacológica sobre múltiples sistemas corporales. En lo que respecta al embarazo y la lactancia, no existe evidencia científica suficiente que garantice la seguridad del consumo de ginsenósidos en mujeres gestantes o lactantes; por lo tanto, su uso está contraindicado en estos grupos debido a la falta de estudios clínicos que descarten efectos teratogénicos (malformaciones fetales) o alteraciones en el desarrollo del lactante a través de la leche materna. Para niños menores de 12 años, el uso no está recomendado, ya que el desarrollo hormonal y metabólico en etapas pediátricas es altamente sensible a los compuestos bioactivos, y la falta de datos sobre la farmacocinética en niños impide establecer una dosis segura. En cuanto a las interacciones farmacológicas, el riesgo es significativo. Con la metformina y otros hipoglucemiantes, Panax quinquefolius puede potenciar el efecto hipoglucemiante (reducción de azúcar en sangre), aumentando el riesgo de hipoglucemia severa. Con la warfarina y otros anticoagulantes, existe un riesgo de alterar la cascada de coagulación, lo que podría incrementar el riesgo de hemorragias.
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