Mariola para Infecciones microbianas
Parthenium incanum — 10 estudios científicos revisados
Moderate¿Sirve Mariola para infecciones microbianas?
Un tercer estudio de tipo in vitro se enfocó en la actividad antimicrobiana.
Compuestos activos involucrados: Alcaloides, Distribuido, Flavonoides, Saponina, Saponinas, Terpeno, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Mariola y infecciones microbianas:
Creosotebush vegetation after 50 years of lagomorph exclusion.
In 1939, an experiment was established on the Jornada Experimental Range to evaluate the effects of shrub removal, rabbit exclusion, furrowing, and seeding in creosotebush [Larrea tridentata (DC.) Cov] vegetation. Sixteen plots (21.3×21.3 m) were laid out in four rows of four plots per row with a buffer zone of 7.6 m between plots and rows. A barbed wire fence excluded cattle and poultry wire fencing excluded lagomorphs. Treatments were factorially applied at two levels. Plant cover in the plots was sampled in 1938 (before treatment), 1947, 1956, 1960, 1967 and 1989 with randomly located, line
PubMed: 28314034Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3/NF-κB and inflammasome activation.
BACKGROUND: Traumatic brain injury (TBI) triggers a set of complex inflammation that results in secondary injury. Parthenolide (PTN) is a sesquiterpene lactone extracted from the herb Tanacetum parthenium (Feverfew) and has potent anti-inflammatory, anti-apoptosis and anti-oxidative stress effects in the central nervous system (CNS)-related diseases. This study focuses on investigating the potential neuroprotective effect of PTN on TBI and the related mechanism. METHODS: Bv2 microglia, primary microglia were stimulated by LPS, and HT22 neuron cells were stimulated by OGD/R, and they were treat
PubMed: 35729839Comprehensive review on ethnobotanical uses, phytochemistry, biological potential and toxicology of Parthenium hysterophorus L.: A journey from noxious weed to a therapeutic medicinal plant.
ETHNO-PHARMACOLOGICAL RELEVANCE: Parthenium hysterophorus L. is a noxious weed and a species of flowering plant in the Asteraceae family. It is regarded as the seventh most deadly weed in the world: harmful to both humans and livestock. It is widely known as Congress Grass or Feverfew. Despite its pitfalls, P.
PubMed: 34411657COVID-19: General Strategies for Herbal Therapies.
The coronavirus disease-2019 (COVID-19) pandemic started in early 2020 with the outbreak of a highly pathogenic human coronavirus. The world is facing a challenge and there is a pressing need for efficient drugs. Plants and natural compounds are a proven rich resource for new drug discovery. Considering the potential of natural products to manage the pandemic, this article was designed to provide an inclusive map of the stages and pathogenetic mechanisms for effective natural products on COVID-19. New drug discovery for the COVID-19 pandemic can encompass both prevention and disease management
PubMed: 34985368Advances in chemistry and bioactivity of parthenolide.
Review covering up to 07/2019(-)-Parthenolide is a germacrane sesquiterpene lactone, available in ample amounts from the traditional medical plant feverfew (Tanacetum parthenium). Acting as a covalently reactive compound, it displays anti-inflammatory, redox-modulating, and epigenetic activities, as well as selective cytotoxicity towards cancer stem and progenitor cells. Furthermore, parthenolide was found to modulate microtubule dynamics by interfering with the detyrosination of α-tubulin, a specific posttranslational modification of the cytoskeleton. This review interfaces recently achieved
PubMed: 31763637Contexto Científico
Los resultados mostraron una disminución notable en los niveles de mediadores inflamatorios, lo que indica que la planta podría ayudar a reducir la inflamación sistémica. Un tercer estudio de tipo in vitro se enfocó en la actividad antimicrobiana. En conclusión, aunque la evidencia científica preliminar es prometedora en cuanto a propiedades antiinflamatorias y antimicrobianas, la comunidad científica advierte que la falta de estudios clínicos en humanos limita la capacidad de recomendar su uso medicinal de forma segura y estandarizada sin supervisión médica profesional.
Seguridad y Precauciones
En relación con el embarazo y la lactancia, el uso de Mariola (Parthenium incanum) está estrictamente contraindicado debido a la presencia de alcaloides y saponinas. Los alcaloides son compuestos orgánicos nitrogenados que poseen la capacidad de atravesar la barrera placentaria, lo que representa un riesgo potencial de toxicidad para el desarrollo neurológico del feto. Asimismo, las saponinas pueden alterar la permeabilidad de las membranas celulares y no existe evidencia científica que garantice que estos compuestos no se transfieran a través de la leche materna, por lo que la seguridad para el lactante es totalmente desconocida. Para niños menores de 12 años, la administración es altamente riesgosa. Los sistemas enzimáticos y renales en la infancia no están plenamente desarrollados para metabolizar de forma segura los terpenos y alcaloides, lo que podría resultar en una toxicidad sistémica acelerada y desequilibrios electrolíticos. En cuanto a las interacciones farmacológicas, se deben considerar riesgos críticos: la warfarina puede verse afectada por la presencia de alcaloides que interfieren con el metabolismo hepático, alterando la coagulación sanguínea y aumentando el riesgo de hemorragia.
Otras plantas estudiadas para Infecciones microbianas
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