Phyllanthus para Inflamación sistémica
Phyllanthus acidus — 6 estudios científicos revisados
Preliminary¿Sirve Phyllanthus para inflamación sistémica?
Contiene compuestos bioactivos como triterpenos y flavonoides que poseen propiedades antiinflamatorias documentadas en estudios in vitro.
Compuestos activos involucrados: Flavonoides, Glucósidos, Terpenoides, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Phyllanthus y inflamación sistémica:
Phyllanthus acidus (L.) Skeels: A review of its traditional uses, phytochemistry, and pharmacological properties.
ETHNOPHARMACOLOGICAL RELEVANCE: Phyllanthus acidus (L.) Skeels is not only used for its edible fruits but also used to treat a wide spectrum of diseases such as inflammatory, rheumatism, bronchitis, asthma, respiratory disorder, hepatic diseases and diabetes in India, Asia, the Caribbean region, and Central and South America. This paper aims to discuss the current understanding regarding the traditional uses, phytochemical and pharmacological studies of P. acidus, and their possible research opportunities. MATERIALS AND METHODS: All information on P. acidus was collected from various electroni
PubMed: 31991202Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells.
Cancer cells generally exhibit 'iron addiction' phenotypes, which contribute to their vulnerability to ferroptosis inducers. Ferroptosis is a newly discovered form of programmed cell death caused by iron-dependent lipid peroxidation. In the present study, pacidusin B, a dichapetalin-type triterpenoid from Phyllanthus acidus (L.) Skeels (Euphorbiaceae), induces ferroptosis in the HT1080 human fibrosarcoma cell line. Cells treated with pacidusin B exhibited the morphological characteristic 'ballooning' phenotype of ferroptosis. The biochemical hallmarks of ferroptosis were also observed in pacid
PubMed: 38780674Genetic diversity analysis of Phyllanthus acidus Skeels of north-east India: Insights from multivariate analysis.
Phyllanthus is the largest genera of Phyllanthaceae mostly distributed in tropical and subtropical region of southeast Asia. Phyllanthus acidus (star gooseberry) is one important species of Phyllanthus predominantly found in north-eastern region of India having medicinal significance. The present investigation was focused to assess the genetic variability of 20 accessions of Phyllanthus acidus and to identify the elite types based on various physico-biochemical attributes. The findings underscored a remarkable range of diversity among the accessions. Correlation coefficients unveiled meaningfu
PubMed: 39994217Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities.
Phytochemical investigation on the nonpolar extracts of P. acidus leaves afforded three new cleistanthane diterpenoids, named phyllanacidins A-C (1-3), in addition to three known ones (4-6). Among them, compounds 2 and 3 represent the first examples of 17-nor cleistanthane diterpenoids. Their structures including absolute configurations were elucidated on the basis of extensive spectroscopic data and single crystal X-ray diffraction analysis. All the isolated cleistanthane diterpenoids were evaluated for their cytotoxic activities against five human cancer cell lines.
PubMed: 33276011Effects of Arbaroi (Phyllanthus acidus) pulp extract on physicochemical characteristics, oxidative stability and antimicrobial activity in chicken patties at refrigerated storage.
The antioxidant and antimicrobial effects of Phyllanthus acidus fruit pulp (PAFP) extract were evaluated and compared with those of butylated hydroxytoluene (BHT) and sodium nitrate (SN) in uncooked chicken patties on the 1st, 5th and 10th days of refrigerated storage. Five types of meatballs were formulated: control (T0), 0.1% PAFP extract (T1), 0.3% PAFP extract (T2), 0.02% BHT (T3) and 0.007% SN (T4). Physicochemical characteristics were assessed by measuring pH, cooking loss, and color. To evaluate the antioxidant activity, heme iron content, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging
PubMed: 41579600Seguridad y Precauciones
La seguridad del uso de Phyllanthus acidus es un área de investigación incipiente, ya que, como se señala en la revisión de [PMID 31991202], la mayoría de los estudios actuales se han realizado en modelos in vitro o en animales, careciendo de ensayos clínicos robustos en humanos que permitan establecer perfiles de seguridad definitivos. En lo que respecta al embarazo y la lactancia, no existe evidencia científica suficiente que garantice la ausencia de efectos teratogénicos (malformaciones fetales) o alteraciones en el desarrollo del neonato. Debido a la presencia de compuestos bioactivos como triterpenos y glucósidos, que pueden cruzar la barrera placentaria o excretarse en la leche materna, el uso de extractos concentrados de esta planta debe evitarse estrictamente en mujeres gestantes y lactantes para prevenir riesgos impredecibles. Para niños menores de 12 años, la seguridad no está establecida; sus sistemas metabólicos y renales están en desarrollo, lo que podría resultar en una toxicidad inesperada ante dosis que en adultos podrían ser tolerables. En cuanto a interacciones farmacológicas, se deben tener precauciones críticas: primero, debido a su actividad hipoglucemiante (capacidad para reducir el azúcar en sangre) documentada en estudios experimentales [PMID 31991202], el consumo de la planta junto con fármacos como la metformina o la insulina podría potenciar excesivamente el efecto hipoglucemiante, provocando crisis de hipoglucemia severa. Segundo, su potencial efecto sobre el metabolismo de carbohidratos y posibles efectos sobre el sistema enzimático hepático sugiere precaución al combinarla con antihipertensivos o fármacos que requieran un control glucémico estricto.
Otras plantas estudiadas para Inflamación sistémica
Perfil completo: Ver todos los usos y evidencia de Phyllanthus →