Platycodon para Inflamación gastrointestinal (Colitis)
Platycodon grandiflorus — 4 estudios científicos revisados
Moderate¿Sirve Platycodon para inflamación gastrointestinal (colitis)?
Los polisacáridos de Platycodon (PGP) han demostrado en modelos animales la capacidad de regular la inmunidad colónica y reducir la inflamación mediante la modulación de vías de señalización como PI3K/AKT y JAK2/STAT3 [PMID 40653325, PMID 37120245].
Compuestos activos involucrados: Fenoles, Flavonoides, Platycodina, Saponinas
Evidencia Científica
Los siguientes estudios han investigado la relación entre Platycodon y inflamación gastrointestinal (colitis):
Platycodon grandiflorus polysaccharides combined with hesperidin exerted the synergistic effect of relieving ulcerative colitis in mice by modulating PI3K/AKT and JAK2/STAT3 signaling pathways.
Ulcerative colitis (UC) is a chronic inflammatory disorder with a complex etiology, characterized by intestinal inflammation and barrier dysfunction. Platycodon grandiflorus polysaccharides (PGP), the primary component of Platycodon grandiflorus, and hesperidin (Hesp), a prominent active component in Citrus aurantium L. (CAL), have both demonstrated anti-inflammatory properties. This study aims to elucidate the underlying mechanism of the synergistic effect of PGP combined with Hesp on UC, focusing on the coordinated interaction between the phosphatidylinositol 3-kinase (PI3K)/protein kinase B
PubMed: 40653325Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis.
Platycodon grandiflorus polysaccharide (PGP) is one of the main components of P. grandiflorus, but the mechanism of its anti-inflammatory effect has not been fully elucidated. The aim of this study was to evaluate the therapeutic effect of PGP on mice with dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) and explore the underlying mechanisms. The results showed that PGP treatment inhibited the weight loss of DSS-induced UC mice, increased colon length, and reduced DAI, spleen index, and pathological damage within the colon. PGP also reduced the levels of pro-inflammatory cytokines
PubMed: 37120245Platycodon grandiflorus root extract activates hepatic PI3K/PIP3/Akt insulin signaling by enriching gut Akkermansia muciniphila in high fat diet fed mice.
BACKGROUND: Increasing hepatic insulin signaling is found to be an important mechanism of Platycodon grandiflorus root to alleviate metabolic syndrome (MetS) symptoms such as insulin resistance, obesity, hyperlipidemia and hepatic steatosis, but the details are not yet clear. Since the main constituents of Platycodon grandiflorus root were hard to be absorbed by gastrointestinal tract, getting opportunity to interact with gut microbiota, we speculate the gut microorganisms may mediate its effect. PURPOSE: Our work aimed to confirm the critical role of gut microbes in the intervention of Platyc
PubMed: 36610135Effects of excessive Platycodon grandiflorus root on gut microbiota and host co-metabolism in mice.
ETHNOPHARMACOLOGICAL RELEVANCE: Platycodon grandiflorus root, is a widely used herb in East Asia for treating respiratory diseases, but research on its oral safety is limited. AIM OF THE STUDY: This study examines the potential adverse gastrointestinal reactions resulting from excessive consumption of Platycodon grandiflorus root (PR) and its effects on gut microbiota and host co-metabolism. MATERIALS AND METHODS: This study evaluated the effects of different doses (1.5, 4.5, and 7.5 g/kg/day) of PR on ICR mice through gavage. Select the 7.5 g/kg/day dosage group and the control group to asses
PubMed: 40058476Seguridad y Precauciones
El uso de Platycodon grandiflorus debe abordarse con precaución debido a su potente actividad biológica. En cuanto al embarazo y la lactancia, no existe evidencia clínica suficiente en humanos que garantice la seguridad del consumo de sus saponinas esteroidales y polisacáridos durante estas etapas. Debido a que la planta posee efectos inmunomoduladores (capacidad de alterar la respuesta del sistema inmune) y efectos sobre la señalización celular, existe un riesgo teórico de interferencia con el desarrollo fetal o la transferencia de compuestos a través de la leche materna. Se recomienda evitar su uso en mujeres gestantes o lactantes a menos que un médico lo autorice explícitamente. Para niños menores de 12 años, la seguridad no ha sido establecida. Los sistemas fisiológicos en desarrollo son más sensibles a los compuestos bioactivos como las saponinas, que pueden tener efectos irritantes o alterar el equilibrio inmunológico infantil.
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