Prunella para Inflamación sistémica
Prunella vulgaris — 4 estudios científicos revisados
Moderate¿Sirve Prunella para inflamación sistémica?
Sus compuestos (como la luteolina y el ácido rosmarínico) actúan inhibiendo mediadores inflamatorios para reducir la respuesta inflamatoria del cuerpo.
Compuestos activos involucrados: Cumarinas, Esculetina, Flavonoides, Luteolina, Terpeno, Terpenoides, Umbeliferona, ácido, ácido oleanólico, ácido rosmarínico, ácido ursólico, ácidos grasos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Prunella y inflamación sistémica:
Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications.
Prunella vulgaris (PV) is a perennial herb belonging to the Labiate family and is widely distributed in the northeastern Asian countries such as Korea, Japan, and China. It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. So far, about 200 compounds have been isolated from PV plant and a majority of these have been characterized mainly as triterpenoids, sterols and flavonoids, followed by coumarins, phenylpropanoids, polysaccharides and volatile oils. This review summarizes and analyz
PubMed: 30864498Mechanism of Prunella vulgaris L. and luteolin in restoring Tfh/Tfr balance and alleviating oxidative stress in Graves' disease.
BACKGROUND: The pathophysiology of Graves' disease (GD) involves imbalances between follicular helper T (Tfh) and follicular regulatory T (Tfr) cells, as well as oxidative stress (OS). Prunella vulgaris L. (Xia Ku Cao, XKC) and its primary bioactive compound, luteolin, are recognized for their potential in treating GD. Yet, the mechanism accounting for the immune-modulatory and antioxidant effects of XKC remains elusive. PURPOSE: This study aims to evaluate the pharmacological effects and elucidate the underlying mechanism of XKC and luteolin in a GD mouse model induced by recombinant adenovir
PubMed: 38879922Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules: A meta-analysis.
BACKGROUND: Prunella vulgaris (PV), a traditional Chinese medical herb, is considered beneficial for some thyroid diseases. However, the effectiveness is not consistent in different studies. This review compiles the evidence from randomized controlled trials (RCTs) and quantifies the effects of PV preparation on thyroid nodules. METHODS: Eight databases were searched up to April 2021 to identify eligible studies. Only RCTs were included.
PubMed: 34731129Therapeutic role of Prunella vulgaris L. polysaccharides in non-alcoholic steatohepatitis and gut dysbiosis.
OBJECTIVE: Prunella vulgaris L. has long been used for liver protection according to traditional Chinese medicine theory and has been proven by modern pharmacological research to have multiple potential liver-protective effects. However, its effects on non-alcoholic steatohepatitis (NASH) are currently uncertain. Our study explores the effects of P. vulgaris polysaccharides on NASH and intestinal homeostasis.
PubMed: 40204563Seguridad y Precauciones
La seguridad en el uso de Prunella vulgaris es un campo que requiere cautela, especialmente debido a su compleja composición química que incluye flavonoides, terpenoides y ácidos fenólicos. En cuanto al embarazo y la lactancia, no existe evidencia clínica suficiente en humanos que garantice la seguridad del consumo de esta planta en mujeres gestantes o lactantes. Debido a que compuestos como la luteolina y el ácido ursólico pueden tener efectos biológicos sistémicos, el riesgo de interferencia con el desarrollo fetal o la transferencia a través de la leche materna es una preocupación teórica importante. Se recomienda evitar su uso en estos periodos para prevenir cualquier riesgo de toxicidad neonatal o complicaciones gestacionales. Para niños menores de 12 años, el uso de Prunella vulgaris no está recomendado. Los sistemas fisiológicos en desarrollo, particularmente los ejes hormonales y metabólicos, son altamente sensibles a los compuestos bioactivos; la falta de estudios de seguridad pediátrica hace que cualquier administración sea potencialmente riesgosa.
Otras plantas estudiadas para Inflamación sistémica
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