Rheum para Elevación del nitrógeno ureico en sangre (BUN)
Rheum officinale — 6 estudios científicos revisados
Moderate¿Sirve Rheum para elevación del nitrógeno ureico en sangre (bun)?
A través de sus propiedades farmacológicas, puede ayudar a la reducción de los niveles de BUN, lo cual es un marcador de la función renal.
Compuestos activos involucrados: Aloemodina, Antraceno, Arginina, Emodina, Flavonoides, Rafonticina, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Rheum y elevación del nitrógeno ureico en sangre (bun):
Rheum officinale (a traditional Chinese medicine) for chronic kidney disease.
BACKGROUND: Chronic kidney disease (CKD) is a major public health issue worldwide. Standard therapies to delay CKD progression include dietary protein restriction and administration of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) to help control blood pressure and confer additional renoprotective effects. Despite such interventions, CKD incidence and mortality rates continue to increase. Rheum officinale (Da Huang) a medicinal herb used widely in China to treat CKD has been reported to offer a range of pharmacological properties that may delay disease
PubMed: 22786510Effects of adding Rheum officinale to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on renal function in patients with chronic renal failure: A meta-analysis of randomized controlled trials .
OBJECTIVE: <italic>Rheum officinale</italic> is a traditional medicinal herb used widely in China to treat chronic renal failure, but the proof of evidence-based medicine is poor. This meta-analysis aims to assess the benefits of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) supplemented with <italic>Rheum officinale</italic> for delaying the progression of chronic renal failure. MATERIALS AND METHODS: The MEDLINE, EMBASE, Cochrane Library, SinoMed, Chinese National Knowledge Infrastructure, Wanfang, and VIP databases were searched to identify studies
PubMed: 29208203Rheum officinale Baill. Treats zebrafish embryo thrombosis by regulating NOS3 expression in the arginine biosynthesis pathway.
BACKGROUND: Rheum officinale Baill. (ROB), as one of the traditional Chinese medicines for promoting blood circulation and removing blood stasis, has a wide range of pharmacological effects, such as cardiovascular protection, and has become a common drug in the clinical care of thrombosis. OBJECTIVE: Although there are some pharmacological studies on ROB in the treatment of thrombotic diseases, the mechanism and material basis are still unclear. Based on the arginine biosynthesis signalling pathway, this research explored the target proteins and metabolites related to the intervention of ROB i
PubMed: 35182903Rheum officinale and Salvia miltiorrhiza inhibit renal fibrosis via miR-21/PTEN/Akt signaling pathway in vitro and in vivo.
ETHNOPHARMACOLOGICAL RELEVANCE: As one of the main components of many famous Chinese herbal formulas, Rheum palmatum L. and Salvia miltiorhiza Bunge (RS) are extensively used to treat chronic kidney disease (CKD). RS has been proved to improve renal function and relieve renal fibrosis (RF), but the potential mechanism remains a mystery. AIM OF THE STUDY: The purpose of this study is to determine whether microRNA-21 (miR-21) is associated with RF progression, as well as whether RS protects against RF through miR-21/PTEN/AKT signaling. MATERIALS AND METHODS: (1) The rat model of RF was establish
PubMed: 36513264Insights into the functional characteristics of rhubarb (Rheum officinale Baill) treatment on experimental traumatic brain injury through network pharmacology with metagenomics.
BACKGROUND: Traumatic brain injury (TBI) imposes a heavy burden on society and families owing to its high morbidity and mortality. Rhubarb has been noticed in the Chinese herb for treating TBI. The pharmacological effects include anti-inflammation, anti-bacterial, and purgative. But little is known about its potential mechanism when treating TBI. PURPOSE: In this study, we profiled the pharmacological and intestinal functional characteristics of rhubarb in post-TBI mice.
PubMed: 40472396Seguridad y Precauciones
El uso de Rheum officinale debe abordarse con extrema cautela debido a su potente actividad farmacológica, especialmente en poblaciones vulnerables. En el caso de mujeres embarazadas y en periodo de lactancia, el uso de esta planta está estrictamente contraindicado. Los componentes activos, como las antraquinonas (emodina, aloe-emodina y fisción), pueden atravesar la barrera placentaria y afectar el desarrollo fetal, pudiendo provocar contracciones uterinas o efectos teratogénicos. Durante la lactancia, estos compuestos pueden excretarse en la leche materna, exponiendo al lactante a riesgos de toxicidad gastrointestinal o alteraciones metabólicas. En niños menores de 12 años, la seguridad no ha sido establecida y se desaconseja su uso debido a que su sistema digestivo y metabólico es más sensible a los efectos purgantes y a la absorción de compuestos bioactivos, lo que podría derivar en desequilibrios electrolíticos severos. Respecto a las interacciones farmacológicas, Rheum officinale presenta riesgos significativos.
Perfil completo: Ver todos los usos y evidencia de Rheum →