Rheum para Fibrosis renal
Rheum officinale — 4 estudios científicos revisados
Preliminary¿Sirve Rheum para fibrosis renal?
La planta puede actuar sobre la vía de señalización miR-21/PTEN/Akt, lo que podría ayudar a mitigar el proceso de cicatrización excesiva en el tejido renal.
Compuestos activos involucrados: Aloemodina, Antraceno, Arginina, Emodina, Flavonoides, Rafonticina, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Rheum y fibrosis renal:
Rheum officinale and Salvia miltiorrhiza inhibit renal fibrosis via miR-21/PTEN/Akt signaling pathway in vitro and in vivo.
ETHNOPHARMACOLOGICAL RELEVANCE: As one of the main components of many famous Chinese herbal formulas, Rheum palmatum L. and Salvia miltiorhiza Bunge (RS) are extensively used to treat chronic kidney disease (CKD). RS has been proved to improve renal function and relieve renal fibrosis (RF), but the potential mechanism remains a mystery. AIM OF THE STUDY: The purpose of this study is to determine whether microRNA-21 (miR-21) is associated with RF progression, as well as whether RS protects against RF through miR-21/PTEN/AKT signaling. MATERIALS AND METHODS: (1) The rat model of RF was establish
PubMed: 36513264Anthraquinones from
Renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) has become a significant public health concern due to its high morbidity and mortality.
PubMed: 40657042Rheum officinale (a traditional Chinese medicine) for chronic kidney disease.
BACKGROUND: Chronic kidney disease (CKD) is a major public health issue worldwide. Standard therapies to delay CKD progression include dietary protein restriction and administration of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) to help control blood pressure and confer additional renoprotective effects. Despite such interventions, CKD incidence and mortality rates continue to increase. Rheum officinale (Da Huang) a medicinal herb used widely in China to treat CKD has been reported to offer a range of pharmacological properties that may delay disease
PubMed: 22786510Effects of adding Rheum officinale to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on renal function in patients with chronic renal failure: A meta-analysis of randomized controlled trials .
OBJECTIVE: <italic>Rheum officinale</italic> is a traditional medicinal herb used widely in China to treat chronic renal failure, but the proof of evidence-based medicine is poor. This meta-analysis aims to assess the benefits of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) supplemented with <italic>Rheum officinale</italic> for delaying the progression of chronic renal failure. MATERIALS AND METHODS: The MEDLINE, EMBASE, Cochrane Library, SinoMed, Chinese National Knowledge Infrastructure, Wanfang, and VIP databases were searched to identify studies
PubMed: 29208203Seguridad y Precauciones
El uso de Rheum officinale debe abordarse con extrema cautela debido a su potente actividad farmacológica, especialmente en poblaciones vulnerables. En el caso de mujeres embarazadas y en periodo de lactancia, el uso de esta planta está estrictamente contraindicado. Los componentes activos, como las antraquinonas (emodina, aloe-emodina y fisción), pueden atravesar la barrera placentaria y afectar el desarrollo fetal, pudiendo provocar contracciones uterinas o efectos teratogénicos. Durante la lactancia, estos compuestos pueden excretarse en la leche materna, exponiendo al lactante a riesgos de toxicidad gastrointestinal o alteraciones metabólicas. En niños menores de 12 años, la seguridad no ha sido establecida y se desaconseja su uso debido a que su sistema digestivo y metabólico es más sensible a los efectos purgantes y a la absorción de compuestos bioactivos, lo que podría derivar en desequilibrios electrolíticos severos. Respecto a las interacciones farmacológicas, Rheum officinale presenta riesgos significativos.
Perfil completo: Ver todos los usos y evidencia de Rheum →