Rheum para Inflamación sistémica (como en la pancreatitis aguda)
Rheum palmatum — 7 estudios científicos revisados
Moderate¿Sirve Rheum para inflamación sistémica (como en la pancreatitis aguda)?
A través de la regulación de la diferenciación de células Th17 y la inhibición de factores inflamatorios como IL-1β e IL-6 (PMID 37861962).
Compuestos activos involucrados: Antraquinona, Crisofanol, Emodina, Fisiona, Flavonoides, Glucósidos, Saponinas, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Rheum y inflamación sistémica (como en la pancreatitis aguda):
Uncovering the mechanistic basis of
CONTEXT: OBJECTIVE: This study investigates rhubarb's therapeutic effects and underlying mechanisms in CKD. MATERIALS AND METHODS: High-performance liquid chromatography (HPLC) established a rhubarb fingerprint to ensure quality control. Network pharmacology and Mendelian randomization identified primary CKD therapeutic targets. Inflammation, oxidative stress, and renal performance were assessed through ELISAs and biochemical tests. Renal structure and fibrosis were examined using hematoxylin-eosin and Masson staining.
PubMed: 40783939Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation.
OBJECTIVE: To identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge., (Dahuang-Danshen, DH-DS) and the mechanism underlying its therapeutic efficacy in acute pancreatitis (AP) using a network pharmacology approach and validate the findings in animal experiments. METHODS: Network pharmacology analysis was used to elucidate the mechanisms underlying the therapeutic effects of DH-DS in AP. The reliability of the results was verified by molecular docking simulation and molecular dynamics simulation. Finally, the results of network pharmacology enrichment analysis were verified
PubMed: 37861962Rheum palmatum L. Attenuates High Fat Diet-Induced Hepatosteatosis by Activating AMP-Activated Protein Kinase.
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disorder characterized by the accumulation of excess fat in the liver. Rheum palmatumL. (RP) decoctions have been reported to ameliorate NAFLD. The aim of the present study was to investigate the effects and underlying mechanisms of RP in fatty liver disease induced by a high-fat diet (HFD) in rats. Low and high doses of aqueous RP extraction were orally administered to HFD-fed rats for six weeks.
PubMed: 27109162Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination.
The application of nanotechnology for antimicrobial delivery has capacity to improve antibacterial efficacy. Currently, the usage of various inorganic and organic carriers, such as metal ions, nano-silicon and surfactants, might increase the potential toxicity of nanoparticles and make their clinical transformation more difficult. Herein, a nano-delivery system was constructed by direct self-assembly of antibacterial phytochemicals (berberine and rhein) originated from traditional Chinese medicine
PubMed: 33088696Phylogenomics, phylogeography and germplasms authentication of the Rheum palmatum complex based on complete chloroplast genomes.
As a traditional Chinese medicine, rhubarb is used to treat several diseases such as severe acute pancreatitis, sepsis and chronic renal failure. However, few studies focused on the authentication of germplasm for the Rheum palmatum complex, and no studies have been conducted to elucidate the evolutionary history of the R. palmatum complex using plastome datasets. Hence, we aim to develop the potential molecular markers to identify the elite germplasms of rhubarb and explore the divergence and biogeographic history of the R. palmatum complex based on the newly sequenced chloroplast genome data
PubMed: 36808315Seguridad y Precauciones
El uso de Rheum palmatum conlleva riesgos significativos que deben ser evaluados con rigor clínico. En el caso de embarazo y lactancia, el uso de esta planta está estrictamente contraindicado. Los compuestos de tipo antraquinona presentes en la planta, como la emodina y la aloe-emodina, han demostrado poseer toxicidad reproductiva (PMID 27188216). Esto significa que pueden interferir con el desarrollo fetal o afectar la fertilidad. Durante la lactancia, aunque la biodisponibilidad oral es baja debido a la glucuronidación, existe el riesgo de que los metabolitos pasen a la leche materna, lo que podría exponer al lactante a efectos laxantes potentes o toxicidad sistémica. Para niños menores de 12 años, el uso no se recomienda debido a la inmadurez de sus sistemas enzimáticos y renales, lo que aumenta la susceptibilidad a la toxicidad.
Perfil completo: Ver todos los usos y evidencia de Rheum →