Trichosanthes para Toxicidad por proteínas inactivadoras de ribosomas (RIPs)
Trichosanthes kirilowii — 10 estudios científicos revisados
Moderate¿Sirve Trichosanthes para toxicidad por proteínas inactivadoras de ribosomas (rips)?
Las proteínas como la tricossantina pueden interferir con la síntesis de proteínas en las células, lo que puede causar daño celular selectivo o neurotoxicidad.
Compuestos activos involucrados: Apigenina, Flavonoides, Glucósidos, Isomultiflorenol, Luteolina, Quercetina, Terpenos, Tricossantina, Compuestos fenólicos, ácidos grasos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Trichosanthes y toxicidad por proteínas inactivadoras de ribosomas (rips):
Trichosanthes kirilowii Maximowicz attenuates dexamethasone induced atrophy in C2C12 myotubes through a Sirtuin 1 associated mechanism.
Glucocorticoids such as dexamethasone (DEX) are commonly used clinically but can induce skeletal muscle atrophy with prolonged or high-dose exposure. Trichosanthes kirilowii Maximowicz (TK), a traditional medicinal herb, has known pharmacological effects, but its impact on muscle atrophy remains unclear. This study investigated the anti-atrophic potential of TK in DEX-induced muscle atrophy models. In C2C12 cells, TK improved cell viability and restored myotube diameter and number, downregulated atrophy markers MuRF-1 and Atrogin-1, and upregulated myogenic markers MyoD, MyoG, and MHC. TK also
PubMed: 41444325Trichosanthes kirilowii lectin ameliorates streptozocin-induced kidney injury via modulation of the balance between M1/M2 phenotype macrophage.
BACKGROUND: Macrophage polarization has been reported to induce podocyte injury, which is a typical characteristic of diabetic nephropathy (DN). Trichosanthes kirilowii is an herb showing renal protective effect as well as immune-regulating effect. Therefore, it was hypothesized that the renal protective effect of Trichosanthes kirilowii was associated with its modulation on macrophage polarization. In the current study, we tested the hypothesis by subjecting DN rats to treatment of Trichosanthes kirilowii lectin (TKL), an active component of Trichosanthes kirilowii. METHOD: DN was induced usi
PubMed: 30396096Ribosome-inactivating Proteins from Root Tubers and Seeds of Trichosan-thes kirilowii and Other Trichosanthes Species.
Ribosome-inactivating proteins have been isolated from Trichosanthes kirilowii root tubers and seeds, including trichosanthin, karasurin and T 33 from root tubers and trichosanthrip, trichokirin, alpha-kirilowin, beta-kirilowin and trichoanguin from seeds. The aforementioned proteins show structural and functional similarities. Among them trichosanthin is the best known and most intensely studied. Trichosanthin manifests anticancer activity in vitro and in tumor bearing mice against a variety of cancers/cancer cell lines. It also exhibits anti-HIV-1 and anti-HSV-1 activities.
PubMed: 27225069Trichosanthes kirilowii ameliorates cisplatin-induced nephrotoxicity in both in vitro and in vivo.
The aim of this study was to explore the protective effects of Trichosanthes kirilowii ethanol extract (TKE) against cisplatin-induced acute renal failure (ARF). In the in vitro study, TKE-pretreated porcine kidney cells (PK15) exhibited enhanced cell viability after cisplatin (15 μg mL(- 1)) treatment in both MTT and crystal violet assays. PK15 cells pretreated with TKE (50 μg mL(- 1)) exhibited increased glutathione content, decreased reactive oxygen species production and ameliorated p53 expression. In vivo study, rats were administered with TKE for 4 weeks before cisplatin (5 mg kg(- 1)) i
PubMed: 25185822Ameliorative effects of Trichosanthes kirilowii Maxim. seed oil on hyperlipidemia rats associated with the regulation of gut microbiology and metabolomics.
The mechanisms underlying the ameliorative effects of polyunsaturated fatty acids (PUFAs) on metabolic disorders induced by a high-fat diet (HFD) remain poorly unclear. In this study, we investigated the anti-hyperlipidemic effects of Trichosanthes kirilowii Maxim. (T. kirilowii) seed oil rich in conjugated linolenic acid in HFD-induced hyperlipidemic rats, by the gut microbiome, cecum bile acids (BAs), and serum metabolomics. The results showed that T.
PubMed: 39593355Seguridad y Precauciones
El uso de Trichosanthes kirilowii debe abordarse con extrema precaución debido a su compleja composición química, que incluye proteínas inactivadoras de ribosomas (RIPs) y diversos glucósidos. En el caso de mujeres embarazadas y en periodo de lactancia, el uso de esta planta está contraindicado. La evidencia científica señala que las proteínas de la especie, como la tricossantina, pueden tener efectos sobre el tejido reproductivo; de hecho, se ha investigado su uso para tratar embarazos ectópicos o cicatrices de cesárea debido a su capacidad de inducir procesos celulares específicos, lo que representa un riesgo de aborto espontáneo o complicaciones gestacionales si se consume de forma no controlada. Para niños menores de 12 años, no se recomienda su administración debido a la falta de estudios de seguridad pediátrica y al riesgo de toxicidad sistémica por las proteínas ribosomales que podrían afectar el desarrollo celular normal. En cuanto a interacciones farmacológicas, la planta puede interactuar con la warfarina y otros anticoagulantes, ya que los componentes de la planta pueden alterar los procesos de coagulación o el metabolismo hepático. Con la metformina y otros antidiabéticos, existe un riesgo de hipoglucemia debido a los efectos metabólicos observados en modelos animales.
Perfil completo: Ver todos los usos y evidencia de Trichosanthes →