Tripterygium para Inmunosupresión (Debilidad inmunológica)
Tripterygium wilfordii — 17 estudios científicos revisados
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La planta actúa inhibiendo la proliferación de células T y B, lo que reduce la respuesta inflamatoria pero aumenta la susceptibilidad a infecciones.
Compuestos activos involucrados: Alcaloides, Flavonoides, Saponinas, Terpenos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Tripterygium y inmunosupresión (debilidad inmunológica):
Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment.
Tripterygium wilfordii Hook F (TwHF)-based therapy is among the most efficient and crucial therapeutics for the treatment of rheumatoid arthritis (RA), which indicates that TwHF is a potential source of novel anti-RA drugs. However, accumulating studies have observed that TwHF-based therapy induces multi-organ toxicity, which prevents the wide use of this herb in clinical practice, although several recent studies have attempted to reduce the toxicity of TwHF. Notably, our research group developed a "Clinical Practice Guideline for Tripterygium Glycosides/Tripterygium wilfordii Tablets in the T
PubMed: 33296090Tripterygium wilfordii Hook F combination therapy with methotrexate for rheumatoid arthritis: An updated meta-analysis.
ETHNOPHARMACOLOGICAL RELEVANCE: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory arthropathy. Tripterygium wilfordii Hook F (TwHF) is common herbal medicine for the treatment of RA in China. However, many important issues, such as efficacy, safety and optimal doses of the combination therapy of TwHF and Methotrexate (MTX) for RA remain to be evaluated. AIMS OF THE STUDY: This study aims to evaluate the efficacy and safety of combination therapy of TwHF and MTX for RA by meta-analysis of randomized clinical trials (RCTs). MATERIAL AND METHODS: Relevant literature was searched from
PubMed: 36706936Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice.
Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation o
PubMed: 30604167Efficacy of Tripterygium wilfordii Hook F on animal model of Diabetic Kidney Diseases: A systematic review and meta-analysis.
ETHNOPHARMACOLOGICAL RELEVANCE: Tripterygium wilfordii Hook F (TwHF) has been clinically applied in the treatment of Diabetic Kidney Diseases (DKD). A large number of animal experiments focused on the TwHF treatment of DKD were conducted every year, but the evidence for these preclinical studies is unclear. AIM OF THE STUDY: This study aims to evaluate the efficacy of TwHF on diabetic nephropathy through a stematic reviews and meta-analysis of animal models, and whether it has an effect on improving kidney pathology, renal function indicators and blood sugar levels, it also summarizes the use
PubMed: 34419607[Overview of hepatotoxicity studies on Tripterygium wilfordii in recent 20 years].
Tripterygium wilfordii is widely used in the treatment of rheumatism with curative effect. However,its toxicity and adverse reactions,especially the hepatotoxicity,rank the first in the herbs induced liver injury,is the key factors hindering its clinical application. This paper reviewed the literatures related to the hepatotoxicity of T. wilfordii in recent 20 years,and summarized the characteristic of hepatotoxicity induced by T. wilfordii,the factors causing liver injury,the mechanism of toxicity,and the measures to reduce toxicity.
PubMed: 31602901Seguridad y Precauciones
El uso de Tripterygium wilfordii (TwHF) conlleva riesgos significativos debido a su potente actividad inmunosupresora y toxicidad multiorgánica. En cuanto al embarazo y la lactancia, su uso está estrictamente contraindicado. Debido a sus propiedades inmunomoduladoras y efectos sobre la proliferación celular, existe un riesgo potencial de teratogenicidad (malformaciones fetales) y alteraciones en el desarrollo embrionario. En la lactancia, los compuestos activos pueden excretarse en la leche materna, lo que podría comprometer la salud del lactante mediante la supresión de su sistema inmunológico en desarrollo o toxicidad sistémica. Para niños menores de 12 años, no existen protocolos de seguridad establecidos y su uso es altamente desaconsejado, ya que los efectos sobre el crecimiento y la maduración inmunológica en etapas pediátricas no han sido evaluados y podrían ser devastadores. Respecto a las interacciones farmacológicas, el uso de TwHF con Metotrexato (MTX) es común en el tratamiento de la artritis reumatoide, pero requiere un monitoreo estrecho debido al riesgo de toxicidad combinada; aunque algunos estudios sugieren beneficios en la tasa de remisión, la sinergia puede exacerbar la mielosupresión (disminución de la producción de células sanguíneas).
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