Tulbaghia para Actividad citotóxica (antitumoral in vitro)
Tulbaghia violacea — 4 estudios científicos revisados
Preliminary¿Sirve Tulbaghia para actividad citotóxica (antitumoral in vitro)?
Los extractos pueden inducir la muerte celular programada (apoptosis) mediante la activación de caspasas y la generación de especies reactivas de oxígeno en células cancerosas específicas [PMID 35094882, PMID 32737339].
Compuestos activos involucrados: Antocianinas, Fenoles, Flavonoides, Polifenoles, Saponinas, Terpenos, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Tulbaghia y actividad citotóxica (antitumoral in vitro):
Unravelling potential biomedical applications of the edible flower Tulbaghia violacea.
Traditionally, edible flowers have been used as foods and for therapeutic purposes, today they have gained importance due to their bioactive compounds such as flavonols, anthocyanins or other phenolic compounds, which give them potential for biomedical applications. This work evaluated a methanolic extract of Tulbaghia violacea. Eleven individual phenolic compounds were found and quantified by mass spectrometry in the extract. Antioxidant activity tests (TEAC, FRAP and DPPH) and other characterization parameters were assayed (total phenolic content and total flavonoid content). In vitro studie
PubMed: 35094882The effect of Tulbaghia violacea extracts on testosterone secretion by testicular cell cultures.
AIM OF THE STUDY: This study aimed to determine the effect of Tulbaghia violacea Harv. on the male reproductive system in vitro by using testicular cell cultures. Tulbaghia violacea is a plant species indigenous to southern Africa and is used locally as a herbal remedy/medicine to treat several ailments. MATERIALS AND METHODS: A 50% ethanol extract of Tulbaghia violacea was prepared. Three-month old male Balb/C mice were sacrificed and testicular cell cultures were prepared.
PubMed: 20723589The genus Tulbaghia (Alliaceae)--a review of its ethnobotany, pharmacology, phytochemistry and conservation needs.
ETHNOPHARMACOLOGICAL RELEVANCE: Tulbaghia is a monocotyledonous genus of herbaceous perennial bulbs predominantly found in Africa. The approximately 63 species have nutritive, ornamental and medicinal value. For centuries, several Tulbaghia species have found diverse uses in traditional medicine. AIM OF THE REVIEW: To evaluate and document the uses, especially the medicinal value of the genus Tulbaghia. The existing gaps in knowledge and possible means for greater development are highlighted.
PubMed: 23838476Phytochemical and biological study of callus cultures of Tulbaghia violacea Harv. Cultivated in Egypt.
As in vitro plant cultures are used extensively to produce bioactive metabolites, our goal was to establish calli from Tulbaghia violacea Harv. flowers and assess the tissue phytochemically and biologically. Murashige & Skoog medium(MS) + 22.6 μM 2,4-dichlorophenoxyacetic acid +2.2 μM benzylaminopurine induced callus from flowers. Gas chromatography/mass spectrometry(GC/MS) analyses of n-hexane extracts of calli(HC) and flowers(HF) revealed 33 and 32 components(92.6 and 98.5%, respectively). Hydrocarbons were predominant in HC (55.0%), whereas a higher percentage of oxygenated compounds was fo
PubMed: 28278648Seguridad y Precauciones
La seguridad en el uso de Tulbaghia violacea es un área que requiere extrema precaución debido a la falta de estudios clínicos extensos en humanos que establezcan límites de seguridad terapéutica. En el caso de mujeres embarazadas o en periodo de lactancia, el uso de esta planta está estrictamente desaconsejado. No existe evidencia científica suficiente que garantice que los compuestos bioactivos, como los flavonoides o los compuestos fenólicos mencionados en estudios de caracterización, no atraviesen la barrera placentaria o se secreten en la leche materna. Dado que la planta ha mostrado actividad citotóxica (capacidad de destruir células) en líneas celulares cancerígenas en entornos de laboratorio [PMID 32737339], existe un riesgo teórico de interferencia con el desarrollo celular fetal o alteraciones en el crecimiento del lactante. En niños menores de 12 años, la seguridad no puede ser establecida; sus sistemas metabólicos y renales están en desarrollo, lo que podría resultar en una toxicidad impredecible ante la ingesta de extractos concentrados. Respecto a las interacciones farmacológicas, la presencia de compuestos con actividad biológica significativa sugiere riesgos críticos.
Perfil completo: Ver todos los usos y evidencia de Tulbaghia →