Wisteria para Alteración de la estructura de glicoproteínas (uso diagnóstico)
Wisteria floribunda — 7 estudios científicos revisados
Strong¿Sirve Wisteria para alteración de la estructura de glicoproteínas (uso diagnóstico)?
La lectina WFA se une a estructuras de carbohidratos alteradas en proteínas secretadas por células enfermas, permitiendo identificar patologías como fibrosis hepática o cáncer (PMID 29265940).
Compuestos activos involucrados: Flavonoides, Lectina, Saponinas
Evidencia Científica
Los siguientes estudios han investigado la relación entre Wisteria y alteración de la estructura de glicoproteínas (uso diagnóstico):
Wisteria floribunda agglutinin-positive Mac-2-binding protein as a diagnostic biomarker in liver cirrhosis: an updated meta-analysis.
Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) had been suggested as a possible glycobiomarker for assessing liver fibrosis. Here, we conducted this updated meta-analysis to systematically investigate the predictive accuracy of WFA+-M2BP for diagnosing liver fibrosis and hepatocellular carcinoma (HCC) by comparing with multiple non-invasive indicators. We searched relevant literatures from Pubmed, Web of Science, EMBASE and Cochrane Library and enrolled 36 eligible studies involving 7,362 patients. Summary results were calculated using bivariate random effects model.
PubMed: 32601332Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels and liver fibrosis: A meta-analysis.
BACKGROUND AND AIM: A reliable, non-invasive biomarker for diagnosis of liver fibrosis in chronic liver disease patients is needed. The aim of this study was to assess by meta-analysis the efficacy of measuring serum levels of Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA METHODS: We performed a meta-analysis using online journal database searches. We identified 39 studies, 21 of which met the criteria for meta-analysis. Sensitivity and specificity of WFA RESULTS: With WFA CONCLUSIONS: These results suggest that serum WFA
PubMed: 28406534Meta-analysis of the diagnostic value of Wisteria floribunda agglutinin-sialylated mucin1 and the prognostic role of mucin1 in human cholangiocarcinoma.
OBJECTIVE: Serum carbohydrate antigen 19-9 (CA19-9) is a widely used tumour marker for cholangiocarcinoma (CCA). However, it is not a necessarily good CCA marker in terms of diagnostic accuracy. The purpose of this study is to evaluate the diagnostic value of DESIGN: Meta-analysis. DATA SOURCES: Studies published in PubMed, Web of Science, The Cochrane Library and the China National Knowledge Infrastructure up to 11 October 2017. ELIGIBILITY CRITERIA: We included reports assessing the diagnostic capacity of WFA-MUC1 and the prognostic role of MUC1 in CCA.
PubMed: 30700476Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients.
BACKGROUND: Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) was a novel marker of liver fibrosis. We aimed to investigate WFA+-M2BP level in assessing liver fibrosis in patients with chronic hepatitis B (CHB) infection. METHODS: A total of 160 CHB patients, who received a liver biopsy, were consecutively recruited. Serum WFA+-M2BP level was quantified at the time point of biopsy. The results were compared with histopathological manifestations and clinical characteristics of the patients.
PubMed: 31393964Serum wisteria floribunda agglutinin-positive human Mac-2 binding protein is unsuitable as a diagnostic marker of occult hepatocellular carcinoma in end-stage liver cirrhosis.
BACKGROUND AND PURPOSE: Serum glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) is a marker of liver fibrosis and hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the diagnostic ability of WFA+-M2BP for occult HCC, which current diagnostic imaging tests fail to detect. METHODS: Patients who underwent hepatectomy for liver transplantation (LT) and whose whole liver could be sliced and subjected to histological examination between 2010 and 2018 were eligible for this study (n = 89). WFA+-M2BP levels were measured in samples collected before
PubMed: 37910585Seguridad y Precauciones
La seguridad en el uso de la planta Wisteria (Wisteria floribunda) es un tema de extrema cautela debido a la presencia de compuestos potencialmente tóxicos en sus tejidos, como las saponinas y otros glucósidos. En el contexto de la seguridad clínica, es fundamental distinguir entre el uso de la planta como material biológico y la presencia de la lectina Wisteria floribunda agglutinin (WFA) en procesos patológicos. (1) Respecto al embarazo y la lactancia, no existe evidencia científica que demuestre la seguridad del consumo de partes de la planta en estas etapas. Debido a que los compuestos de la familia Fabaceae pueden interferir con procesos de desarrollo embrionario o pasar a la leche materna, se desaconseja totalmente su ingesta. La falta de estudios clínicos en humanos sobre la teratogenicidad de sus componentes obliga a mantener una postura de prevención absoluta para evitar malformaciones congénitas. (2) En niños menores de 12 años, el riesgo es significativamente mayor debido a su menor masa corporal y sistemas metabólicos en desarrollo.
Perfil completo: Ver todos los usos y evidencia de Wisteria →