Wisteria para Marcador de fibrosis hepática avanzada
Wisteria floribunda — 17 estudios científicos revisados
Strong¿Sirve Wisteria para marcador de fibrosis hepática avanzada?
La presencia de la proteína Mac-2-binding protein con afinidad por la lectina WFA sirve como un biomarcador para detectar la progresión de la fibrosis y la cirrosis (PMID 32601332).
Compuestos activos involucrados: Flavonoides, Lectina, Saponinas
Evidencia Científica
Los siguientes estudios han investigado la relación entre Wisteria y marcador de fibrosis hepática avanzada:
Wisteria floribunda agglutinin-positive Mac-2-binding protein as a diagnostic biomarker in liver cirrhosis: an updated meta-analysis.
Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) had been suggested as a possible glycobiomarker for assessing liver fibrosis. Here, we conducted this updated meta-analysis to systematically investigate the predictive accuracy of WFA+-M2BP for diagnosing liver fibrosis and hepatocellular carcinoma (HCC) by comparing with multiple non-invasive indicators. We searched relevant literatures from Pubmed, Web of Science, EMBASE and Cochrane Library and enrolled 36 eligible studies involving 7,362 patients. Summary results were calculated using bivariate random effects model.
PubMed: 32601332Wisteria floribunda agglutinin positive glycobiomarkers: a unique lectin as a serum biomarker probe in various diseases.
Serum proteins are generally glycosylated and solubilized, and are thus present as glycoproteins. The glycan structure of glycoproteins reflects cell differentiation status; glycan structures generated by diseased cells are distinguishable from those produced by healthy cells. Proteins may therefore serve as markers of tissues that secrete them. Several strategies for the identification of novel serum biomarkers using a combination of glycoscience-based technologies have been recently proposed. The selection of lectins for use as probes for identification of altered glycan structures represent
PubMed: 29265940Post-treatment serum Wisteria floribunda agglutinin-positive mac-2-binding protein level is a useful predictor of hepatocellular carcinoma development after hepatitis C virus eradication.
AIMS: Recent advances of direct-acting antiviral drugs for hepatitis C virus (HCV) have dramatically improved the sustained virologic response (SVR) rate, but hepatocellular carcinoma (HCC) development rarely occurs even in patients who achieve an SVR. Wisteria floribunda agglutinin-positive mac-2-binding protein (WFA METHODS AND RESULTS: We examined the association between WFA CONCLUSIONS: The assessment of liver fibrosis using the WFA
PubMed: 34622009Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels and liver fibrosis: A meta-analysis.
BACKGROUND AND AIM: A reliable, non-invasive biomarker for diagnosis of liver fibrosis in chronic liver disease patients is needed. The aim of this study was to assess by meta-analysis the efficacy of measuring serum levels of Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA METHODS: We performed a meta-analysis using online journal database searches. We identified 39 studies, 21 of which met the criteria for meta-analysis. Sensitivity and specificity of WFA RESULTS: With WFA CONCLUSIONS: These results suggest that serum WFA
PubMed: 28406534Wisteria floribunda agglutinin-positive human Mac-2-binding protein as a predictive marker of liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfected patients.
AIM: In human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfected patients, the progression of liver failure is reported to be more aggressive than that in HCV mono-infected patients. Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA METHODS: M2BP was measured in 31 HIV/HCV coinfected patients, and we analyzed the correlation between WFA RESULTS: In the HIV/HCV coinfected patients, the serum level of WFA CONCLUSION: In conclusion, WFA
PubMed: 31785125Seguridad y Precauciones
La seguridad en el uso de la planta Wisteria (Wisteria floribunda) es un tema de extrema cautela debido a la presencia de compuestos potencialmente tóxicos en sus tejidos, como las saponinas y otros glucósidos. En el contexto de la seguridad clínica, es fundamental distinguir entre el uso de la planta como material biológico y la presencia de la lectina Wisteria floribunda agglutinin (WFA) en procesos patológicos. (1) Respecto al embarazo y la lactancia, no existe evidencia científica que demuestre la seguridad del consumo de partes de la planta en estas etapas. Debido a que los compuestos de la familia Fabaceae pueden interferir con procesos de desarrollo embrionario o pasar a la leche materna, se desaconseja totalmente su ingesta. La falta de estudios clínicos en humanos sobre la teratogenicidad de sus componentes obliga a mantener una postura de prevención absoluta para evitar malformaciones congénitas. (2) En niños menores de 12 años, el riesgo es significativamente mayor debido a su menor masa corporal y sistemas metabólicos en desarrollo.
Perfil completo: Ver todos los usos y evidencia de Wisteria →