Acacia para Toxicidad celular (Apoptosis)
Acacia victoriae — 5 estudios científicos revisados
Moderate¿Sirve Acacia para toxicidad celular (apoptosis)?
Los compuestos llamados avicinas pueden inducir la muerte celular programada al afectar la función de las mitocondrias, lo que podría causar daño celular no deseado en tejidos sanos.
Compuestos activos involucrados: Flavonoides, Saponinas, Terpenos, Avicina, Inhibido, Terpenoides, Tripsina, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Acacia y toxicidad celular (apoptosis):
Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation.
Anticancer agents target various subcellular components and trigger apoptosis in chemosensitive cells. We have recently reported the tumor cell growth inhibitory properties of a mixture of triterpenoid saponins obtained from an Australian desert tree (Leguminosae) Acacia victoriae (Bentham). Here we report the purification of this mixture into two biologically pure components called avicins that contain an acacic acid core with two acyclic monoterpene units connected by a quinovose sugar. We demonstrate that the mixture of triterpenoid saponins and avicins induce apoptosis in the Jurkat human
PubMed: 11344312Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis.
This report describes the isolation and partial purification of novel triterpenoid saponins [Fraction 35 (F035)] and two pure biologically active derivatives (termed avicins D and G) from Acacia victoriae, an Australian desert tree of the Leguminosae family. F035 and the avicins markedly inhibited the growth of several tumor cell lines with minimum growth inhibition in human foreskin fibroblasts, mouse fibroblasts, and immortalized breast epithelial cells at similar concentrations. F035 and the avicins induced cell cycle (G1) arrest of the human MDA-MB-453 breast cancer cell line and apoptosis
PubMed: 11454696Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae.
Two new saponins named avicins D (1) and G (2) were isolated from the seed pods of the desert legume plant Acacia victoriae. The structures, elucidated by 1D and 2D NMR studies and by chemical means, were characterized as acacic acid-bearing oligosaccharides at C-3 and C-28 with a side chain linked to C-21 comprised of two monoterpene carboxylic acids and a quinovose moiety. Both compounds exhibited potent cytotoxicity (apoptosis) against human T-cell leukemia (Jurkat cells) in vitro.
PubMed: 12828461Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA.
Triterpenoid saponins, which are present in leguminous plants and some marine animals, possess a broad range of biological actions. We have earlier reported the extraction of avicins, a family of triterpenoid saponins obtained from the Australian desert tree Acacia victoriae (Leguminosae: Mimosoideae) that inhibit tumor cell growth and induce apoptosis, in part, by perturbing mitochondrial function. These saponins have also been found to prevent chemical-induced carcinogenesis in mice. This study examines the effect of a triterpene mixture (F094) and a single molecular species (avicin G) isola
PubMed: 11572998Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery.
Avicins are proapoptotic and anti-inflammatory triterpene electrophiles isolated from an Australian desert tree, Acacia victoriae. The presence of two alpha,beta unsaturated carbonyl groups (Michael reaction sites) in the side chain of the avicin molecule prompted us to study its effects on NF-E2-related factor 2 (Nrf2), a redox-regulated transcription factor that controls the expression of a battery of detoxification and antioxidant proteins via its binding to antioxidant response element (ARE). Avicin D-treated Hep G2 cells showed translocation of Nrf2 into the nucleus and a time-dependent i
PubMed: 14702110Seguridad y Precauciones
El consumo o uso de extractos de Acacia victoriae requiere una precaución extrema debido a su compleja composición química. En el caso de mujeres embarazadas o en periodo de lactancia, no existe evidencia científica que garantice la seguridad del uso de las semillas o sus compuestos aislados, como las avicinas, en humanos. Dado que los estudios sobre las avicinas muestran una capacidad para inducir la apoptosis (muerte celular programada) mediante la perturbación mitocondrial [PMID 11344312], existe un riesgo teórico de que estos compuestos puedan interferir con el desarrollo celular fetal o la transferencia a través de la leche materna. No hay datos que establezcan una dosis segura para estos grupos vulnerables. Para niños menores de 12 años, el uso debe evitarse estrictamente. Los sistemas fisiológicos en desarrollo son altamente sensibles a los inhibidores enzimáticos y a los compuestos de actividad biológica potente.
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