Boldo para Disfunción hepática
Peumus boldus — 10 estudios científicos revisados
Moderate¿Sirve Boldo para disfunción hepática?
La boldina ejerce efectos hepatoprotectores mediante la modulación de redes biológicas y la reducción de marcadores de daño oxidativo [PMID 38234264].
Compuestos activos involucrados: boldina, cineol, ascaridol, flavonoides, Alcaloides, Saponinas, Terpeno, Terpenos, Conocido, Saponina, Compuestos fenólicos
Evidencia Científica
Los siguientes estudios han investigado la relación entre Boldo y disfunción hepática:
Antioxidant and Cytotoxic Evaluation of Aqueous Extracts from Hymenochaetaceae Fungi Associated with Endemic Chilean Sclerophyll Forest Trees.
In the search for safe and effective natural antioxidants, this study investigates the antioxidant and cytotoxic properties of aqueous extracts obtained from three fungi of the family Hymenochaetaceae: Inonotus sp., Fulvifomes sp., and Phylloporia boldo, all associated with endemic trees of the Chilean sclerophyll forest. Antioxidant capacity was assessed through DPPH, ABTS, and hydroxyl radical scavenging assays. Fulvifomes sp. exhibited the highest antioxidant activity across all methods, which was consistent with its elevated polyphenol content. P.
PubMed: 40565340Pharmacology of boldine: summary of the field and update on recent advances.
Over the past decade, boldine, a naturally occurring alkaloid found in several plant species including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of human disease. Some of the properties that have been attributed to boldine include antioxidant activities, neuroprotective and analgesic actions, hepatoprotective effects, anti-inflammatory actions, cardioprotective effects and anticancer potential. Compelling data now indicates that boldine blocks connexin (Cx) hemichannels (HCs) and that many if not all of its effects in rodent models of injury and disease a
PubMed: 39346563Boldine: a narrative review of the bioactive compound with versatile biological and pharmacological potential.
OBJECTIVE: Boldine is a plant-derived bioactive compound that has a beneficial impact on human health. Boldine is an aporphine alkaloid mainly obtained from the leaves and bark of the Chilean Boldo tree (Peumus boldus, Family: Monimiaceae). There are plenty of preclinical evidence supports that boldine exerts its beneficial effects against various diseases. Lumiskin™, a patented and marketed formulation by Revitol Skincare for skin brightening, contains Dicetyl boldine, a boldine derivative. CONTENT: All the available information on the Chilean boldo tree (P.
PubMed: 38234264An Overview of Chemistry, Kinetics, Toxicity and Therapeutic Potential of Boldine in Neurological Disorders.
Boldine is an alkaloid obtained from the medicinal herb Peumus boldus (Mol.) (Chilean boldo tree; boldo) and belongs to the family Monimiaceae. It exhibits a wide range of pharmacological effects such as antioxidant, anticancer, hepatoprotective, neuroprotective, and anti-diabetic properties. There is a dearth of information regarding its pharmacokinetics and toxicity in addition to its potential pharmacological activity. Boldine belongs to the aporphine alkaloid class and possesses lipophilic properties which enable its efficient absorption and distribution throughout the body, including the
PubMed: 37462836Tacrolimus and herbs interactions: a review.
The calcineurin inhibitor tacrolimus (TAC) shows inter-and intra-individual variability in blood levels and has a narrow therapeutic index. To reduce the chance of fluctuations in immunosuppressive activity and potential drug interactions, it is critical to keep track of drug concentrations. Cytochrome-P450 (CYP) isoenzymes CYP3A4 and CYP3A5, as well P-glycoprotein (P-gp) are involved in TAC bioavailability. TAC's interactions with herbal extracts are reviewed here, because with more people using TAC, it is becoming crucial to know which extracts, which are often part of self-medication, can a
PubMed: 34620272Seguridad y Precauciones
El uso de Peumus boldus debe abordarse con extrema precaución debido a su compleja composición de alcaloides y terpenos. En el caso de mujeres embarazadas y en periodo de lactancia, su uso está estrictamente desaconsejado. No existen estudios clínicos suficientes que garanticen la ausencia de efectos teratogénicos o riesgos para el desarrollo fetal; además, la boldina y otros compuestos pueden atravesar la barrera placentaria o excretarse en la leche materna, con potenciales efectos sobre el lactante. En niños menores de 12 años, el uso de boldo no se recomienda debido a la inmadurez de sus sistemas enzimáticos hepáticos y renales, lo que incrementa el riesgo de toxicidad por la acumulación de metabolitos. Respecto a las interacciones farmacológicas, el boldo puede alterar significativamente la farmacocinética de medicamentos metabolizados por el sistema del citocromo P450 (CYP450). Se ha observado que el boldo puede inducir el sistema CYP450 y la bomba de eflujo P-gp, lo que podría disminuir la biodisponibilidad de fármacos críticos como el tacrolimus (un inmunosupresor vital para trasplantados) [PMID 39757635].
Perfil completo: Ver todos los usos y evidencia de Boldo →