Cinchona ovata para Toxicidad sistémica por alcaloides
Cinchona ovata — 6 estudios científicos revisados
Moderate¿Sirve Cinchona ovata para toxicidad sistémica por alcaloides?
La acumulación de concentraciones máximas de alcaloides o sus metabolitos en el plasma puede alcanzar niveles de toxicidad [PMID 12479325].
Compuestos activos involucrados: Alcaloides, Caspasa, Cinconina, Quinidina, Quinina
Evidencia Científica
Los siguientes estudios han investigado la relación entre Cinchona ovata y toxicidad sistémica por alcaloides:
Medicinal plants, human health and biodiversity: a broad review.
Biodiversity contributes significantly towards human livelihood and development and thus plays a predominant role in the well being of the global population. According to WHO reports, around 80 % of the global population still relies on botanical drugs; today several medicines owe their origin to medicinal plants. Natural substances have long served as sources of therapeutic drugs, where drugs including digitalis (from foxglove), ergotamine (from contaminated rye), quinine (from cinchona), and salicylates (willow bark) can be cited as some classical examples.Drug discovery from natural sources
PubMed: 25001990Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids.
BACKGROUND: Cinchonine is one of the Cinchona alkaloids that is commercially extracted from the Peruvian bark of Cinchona officinalis L. (Family: Rubiaceae). It is also obtained in much lower quantities from other species of Cinchona, such as Cinchona calisaya, Cinchona succirubra, and Cinchona pubescens, and in some other plants, such as Remijia peruviana. Cinchonine has been historically used as an anti-malarial agent. It also has a wide range of other biological properties, including anti-cancer, anti-obesity, anti-inflammatory, anti-parasitic, antimicrobial, anti-platelet aggregation, and
PubMed: 38031797Dimeric Cinchona alkaloids.
Nature is full of dimeric alkaloids of various types from many plant families, some of them with interesting biological properties. However, dimeric Cinchona alkaloids were not isolated from any species but were products of designed partial chemical synthesis. Although the Cinchona bark is amongst the sources of oldest efficient medicines, the synthetic dimers found most use in the field of asymmetric synthesis. Prominent examples include the Sharpless dihydroxylation and aminohydroxylation ligands, and dimeric phase transfer catalysts. In this article the syntheses of Cinchona alkaloid dimers
PubMed: 25586655A matter of some sensitivity.
The development of sensitive chromatographic and spectroscopic techniques for the isolation and structure determination of natural products has greatly facilitated phytochemical investigations. Chemical investigations of herbarium material have resulted in the isolation of indole, quinoline and isoquinoline alkaloids from a wide number of plants. Examples of novel natural products from higher plants are given and include alkaloids, terpenoids, phenolics and quinones. Some plants investigated have not yielded the types of constituents which would have been predicted from them. Plant tissue cult
PubMed: 7786474The Fever Tree: from Malaria to Neurological Diseases.
This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine. Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars. Over those 400 years, the medical use of cinchona alkaloids has evolved from bark extracts to chemical synthesis and controlled clinical trials. At the present time, the use of quinine and quinidine has declined, to a large extent due to their toxicity. However, quinine is still being pres
PubMed: 30477182Seguridad y Precauciones
La seguridad en el uso de productos derivados de la corteza de Cinchona ovata, la cual contiene alcaloides potentes como la quinina y la cinchonina, es un asunto de extrema importancia debido a su estrecho margen terapéutico. (1) En lo que respecta al embarazo y la lactancia, el uso de alcaloides de la cinchona debe evitarse rigurosamente sin supervisión médica estricta. Aunque la quinina se ha utilizado históricamente en entornos de recursos limitados para tratar la malaria en mujeres embarazadas [PMID 30477182], su toxicidad es un riesgo significativo que requiere un balance riesgo-beneficio clínico muy preciso. (2) Para niños menores de 12 años, el uso de extractos de Cinchona ovata no se recomienda de forma generalizada debido a la falta de estudios de dosificación segura en poblaciones pediática y el riesgo de toxicidad sistémica. (3) Las interacciones farmacológicas son críticas; por ejemplo, la administración de estos alcaloides puede interactuar con fármacos que afectan el ritmo cardíaco, dado que la quinina y la quinidina tienen efectos sobre la conducción cardíaca [PMID 30477182]. Además, la estructura de los alcaloides de cinchona puede presentar riesgos de toxicidad retiniana si se combinan con ciertos agentes o bajo exposición a luz UVA [PMID 12479325].
Otras plantas estudiadas para Toxicidad sistémica por alcaloides
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