Quina roja para Inflamación
Cinchona pubescens — 5 estudios científicos revisados
Preliminary¿Sirve Quina roja para inflamación?
Mecanismos de acción celular de los alcaloides: La literatura revisada en [PMID 38031797] destaca que la cinconina tiene un efecto antiinflamatorio que puede mitigar los impactos de las dietas...
Compuestos activos involucrados: Alcaloides, Cinconidina, Cinconina, Flavonoides, Quinidina, Quinina, Saponinas
Evidencia Científica
Los siguientes estudios han investigado la relación entre Quina roja y inflamación:
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids.
BACKGROUND: Cinchonine is one of the Cinchona alkaloids that is commercially extracted from the Peruvian bark of Cinchona officinalis L. (Family: Rubiaceae). It is also obtained in much lower quantities from other species of Cinchona, such as Cinchona calisaya, Cinchona succirubra, and Cinchona pubescens, and in some other plants, such as Remijia peruviana. Cinchonine has been historically used as an anti-malarial agent. It also has a wide range of other biological properties, including anti-cancer, anti-obesity, anti-inflammatory, anti-parasitic, antimicrobial, anti-platelet aggregation, and
PubMed: 38031797Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects.
Herbal extracts represent an ample source of natural compounds, with potential to be used in improving human health. There is a growing interest in using natural extracts as possible new treatment strategies for inflammatory diseases. We therefore aimed at identifying herbal extracts that affect inflammatory signaling pathways through toll-like receptors (TLRs), TLR2 and TLR4. Ninety-nine ethanolic extracts were screened in THP-1 monocytes and HeLa-TLR4 transfected reporter cells for their effects on stimulated TLR2 and TLR4 signaling pathways. The 28 identified anti-inflammatory extracts were
PubMed: 30307962Glycyrrhizin alleviates the toxicity of hydroxychloroquine in treating oral lichen planus by occupying heat shock protein 90 alpha.
BACKGROUND: Oral lichen planus (OLP) is a common chronic inflammatory disease with the potential of malignant transformation. Hydroxychloroquine (HCQ), derived from quinine originating from Cinchona spp. bark, is a commonly prescribed off-label for OLP. However, it lacks robust evidence-based medicine practice, as well as theoretical guidance for its pharmacodynamic targets and for mitigating adverse reactions. PURPOSE: To compare the efficacy of HCQ with first-line treatment prednisone for treating severe erosive OLP and to identify compatible phytomedicine that is reasonably available based
PubMed: 39550918Artemisinin-hydroxychloroquine combination from traditional antimalarial medicine attenuates pulmonary fibrosis via PI3K/AKT/GSK3β-mediated inhibition of epithelial-mesenchymal transition.
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisinin and hydroxychloroquine, derived respectively from Artemisia annua L. (Qinghao) and Cinchona calisaya Wedd., have been widely used for centuries to treat malaria and inflammatory disorders. In addition to their antimalarial activity, these compounds exhibit multifunctionality, including anti-inflammatory, antifibrotic, and immunomodulatory effects. Although preliminary studies suggested that the artemisinin-hydroxychloroquine (AH) combination may attenuate idiopathic pulmonary fibrosis (IPF), its underlying mechanisms remain poorly understood. AIM OF
PubMed: 41076144Medicinal plants, human health and biodiversity: a broad review.
Biodiversity contributes significantly towards human livelihood and development and thus plays a predominant role in the well being of the global population. According to WHO reports, around 80 % of the global population still relies on botanical drugs; today several medicines owe their origin to medicinal plants. Natural substances have long served as sources of therapeutic drugs, where drugs including digitalis (from foxglove), ergotamine (from contaminated rye), quinine (from cinchona), and salicylates (willow bark) can be cited as some classical examples.Drug discovery from natural sources
PubMed: 25001990Seguridad y Precauciones
El uso de la corteza de Quina roja (Cinchona pubescens) conlleva riesgos significativos debido a su compleja composición de alcaloides, como la quinina, la cinconina y la cinconidina. Debido a la variabilidad química reportada en mercados populares, donde la autenticidad de la especie no siempre está garantizada [PMID 24971797], la toxicidad puede ser impredecible. En el caso de mujeres embarazadas y en periodo de lactancia, el consumo está estrictamente contraindicado. Los alcaloides de la quina pueden atravesar la barrera placentaria y la barrera hematoencefálica, con el potencial de causar efectos teratogénicos o alteraciones en el desarrollo fetal. Durante la lactancia, los compuestos pueden excretarse en la leche materna, exponiendo al lactante a riesgos de toxicidad sistémica y alteraciones en el ritmo cardíaco. Para niños menores de 12 años, el uso debe evitarse por completo debido a la inmadurez de sus sistemas metabólicos para procesar alcaloides complejos, lo que aumenta el riesgo de intoxicación aguda.
Otras plantas estudiadas para Inflamación
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