Gymnema sylvestre para Inflamación
Gymnema sylvestre — 5 estudios científicos revisados
Preliminary¿Sirve Gymnema sylvestre para inflamación?
El compuesto G3OG modula la vía de señalización NF-κB/MAPK, lo que ayuda a reducir la respuesta inflamatoria en tejidos pulmonares.
Compuestos activos involucrados: ácido gimnémico, gimnemagenina, gurmarina, Flavonoides, Gymnemasaponina, Saponina, Saponinas, Terpenoides, ácido
Evidencia Científica
Los siguientes estudios han investigado la relación entre Gymnema sylvestre y inflamación:
Gymnemagenin-3-O-glucuronide mitigates lipopolysaccharide-induced acute lung inflammation/injury by regulating the NF-κB/MAPK signalling.
Acute lung injury (ALI) and lung inflammation are key causes of death in bacterial or viral lung infections, largely due to cytokine storms and the lack of effective therapies. Gymnema sylvestre hydroalcoholic extract has been reported to exert anti-inflammatory effects in both in vitro and in vivo models of lung inflammation; however, the specific bioactive constituent responsible for its therapeutic efficacy remains unidentified. This study aimed to screen the bioactive molecules and evaluate their therapeutic potential using a lipopolysaccharide (LPS)-induced differentiation model in both i
PubMed: 41915178Biotechnological approaches for the production of gymnemic acid from Gymnema sylvestre R. Br.
Diabetes is a chronic disease that affects several organs and can be treated using phytochemicals found in medicinal plants. Gymnema sylvestre (Asclepiadaceae) is one such medicinal plant rich in anti-diabetic properties. The plant is commonly known as madhunashini in Sanskrit because of its ability to cure diabetes (sugar). Gymnemic acid (GA) is a phytochemical (a triterpenoid saponin) responsible for the herb's main pharmacological activity. This secondary metabolite has a lot of potential as a phytochemical with pharmacological properties including nephroprotection, hypoglycemia, antioxidan
PubMed: 37266583C-4 gem-dimethylated oleanes of Gymnema sylvestre and their pharmacological activities.
Gymnema sylvestre R. Br., one of the most important medicinal plants of the Asclepiadaceae family, is a herb distributed throughout the World, predominantly in tropical countries. The plant, widely used for the treatment of diabetes and as a diuretic in Indian proprietary medicines, possesses beneficial digestive, anti-inflammatory, hypoglycemic and anti-helmentic effects. Furthermore, it is believed to be useful in the treatment of dyspepsia, constipation, jaundice, hemorrhoids, cardiopathy, asthma, bronchitis and leucoderma. A literature survey revealed that some other notable pharmacologica
PubMed: 24304585Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant.
Gymnema sylvestre (Asclepiadaceae), popularly known as "gurmar" for its distinct property as sugar destroyer, is a reputed herb in the Ayurvedic system of medicine. The phytoconstituents responsible for sweet suppression activity includes triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin. The herb exhibits a broad range of therapeutic effects as an effective natural remedy for diabetes, besides being used for arthritis, diuretic, anemia, osteoporosis, hypercholesterolemia, cardiopathy, asthma, constipation, microbial infections, indigestion, and anti-inf
PubMed: 24511547Radio-protective efficacy of
PURPOSE: Freshwater fish MATERIALS AND METHODS: This study was done via stress marker enzymes, cell cycle analysis (CCA) and DNA damage assay prediction with molecular docking, which are reported here for the first time. The results indicate an elevated LPO level and decreased level of CAT, SOD and GSH due to oxidative stress initiation by RESULTS: In CCA, G0/G1 phase was observed to be the highest in Ami and lowest in GG, against CONCLUSION: Predictive assessment was carried out by docking of Ami, various components of GS with p53, NF-κβ cells and Rad51 proteins structures responsible for
PubMed: 34705596Seguridad y Precauciones
El uso de Gymnema sylvestre debe abordarse con extrema precaución debido a su potente actividad metabólica. En relación con el embarazo y la lactancia, no existe evidencia científica suficiente que garantice la seguridad en humanos; por lo tanto, su uso está contraindicado en mujeres gestantes y lactantes, ya que los efectos de los ácidos gimnémicos sobre el desarrollo fetal y la transferencia de compuestos bioactivos a través de la leche materna no han sido estudiados. En el caso de niños menores de 12 años, se desaconseja su administración debido a que sus sistemas endocrinos y metabólicos están en desarrollo, y la interferencia con la regulación de la glucosa y el crecimiento podría tener consecuencias impredecibles. Respecto a las interacciones farmacológicas, la Gymnema sylvestre presenta riesgos significativos de interacción con fármacos hipoglucemiantes como la metformina, ya que la planta potencia la reducción de la glucosa en sangre, lo que podría derivar en episodios de hipoglucemia severa por un efecto sinérgico no controlado. Asimismo, puede interactuar con la warfarina y otros anticoagulantes, alterando potencialmente la respuesta hematológica, aunque la evidencia es limitada. También debe evitarse su combinación con antihipertensivos, dado que la modulación metabólica de la planta podría influir en la presión arterial de forma indirecta.
Otras plantas estudiadas para Inflamación
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