Hippeastrum para Toxicidad sistémica por alcaloides
Hippeastrum aulicum — 8 estudios científicos revisados
Moderate¿Sirve Hippeastrum para toxicidad sistémica por alcaloides?
La presencia de compuestos bioactivos en la planta puede provocar efectos adversos en diversos órganos al interactuar con receptores celulares específicos.
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hippeastrum y toxicidad sistémica por alcaloides:
Multitarget anti-parasitic activities of isoquinoline alkaloids isolated from Hippeastrum aulicum (Amaryllidaceae).
BACKGROUND: Chagas disease and leishmaniasis affect a significant portion of the Latin American population and still lack efficient treatments. In this context, natural products emerge as promising compounds for developing more effective therapies, aiming to mitigate side effects and drug resistance. Notably, species from the Amaryllidaceae family emerge as potential reservoirs of antiparasitic agents due to the presence of diverse biologically active alkaloids. PURPOSE: To assess the anti-Trypanosoma cruzi and anti-Leishmania infantum activity of five isolated alkaloids from Hippeastrum aulic
PubMed: 38503155Ligand fishing approach to explore Amaryllidaceae alkaloids as potential antiviral candidates targeting SARS-CoV-2 Nsp4.
Ligand fishing, also described as affinity-based assay, represents a convenient and efficient approach to separate potential ligands from complex matrixes or chemical libraries. This approach contributes to the identification of lead compounds that can bind to a specific target. In the context of COVID-19, the search for novel therapeutic agents is crucial. Small molecule-based antiviral drugs, such as Amaryllidaceae alkaloids, have been described as potential candidates because they can inhibit RNA viruses. Among various SARS-CoV-2 proteins, Nsp3, Nsp4, and Nsp6 play a crucial role in the pat
PubMed: 38181554Candimine from Hippeastrum escoipense (Amaryllidaceae): Anti-Trypanosoma cruzi activity and synergistic effect with benznidazole.
BACKGROUND: Chagas disease (CD), caused by Trypanosoma cruzi, represents a health threat to around 20 million people worldwide. Side effects of benznidazole (Bzn) cause 15-20% of patients to discontinue their treatment. Evidence has increased in favor of the use of drug combinations to improve the efficacy and tolerance of the treatment. Natural products are well known to provide structures that could serve as new drugs or scaffolds for CD treatment. Spp of the Amaryllidoideae sub family of Amaryllidaceae family are known by their bioactives alkaloids, which have been reported by their antipar
PubMed: 37037085Studies on the Nonalkaloidal Secondary Metabolites of
Sixteen chemically varied metabolites were isolated from the bulbs of
PubMed: 37546665Anti-Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species.
Diseases caused by trypanosomatid parasites like human African trypanosomiasis (HAT), Chagas disease (CD), leishmaniasis, and malaria are persistent health problems in developing countries that still demand new drug development. The species of the Amaryllidoideae subfamily (Amaryllidaceae) represent a vast source of alkaloids with a wide range of bioactive properties, including antiparasitic effects. The aim of this study was to evaluate the antiparasitic activity of the alkaloids hamayne, 7-hydroxyclivonine, 4-O-methylnangustine, and candimine against Trypanosoma brucei rhodesiense, Trypanoso
PubMed: 40101140Seguridad y Precauciones
El uso de productos derivados de Hippeastrum aulicum debe abordarse con extrema cautela debido a la presencia de alcaloides isoquinolínicos altamente bioactivos, como la haemanthamina y la licorina, los cuales poseen una toxicidad celular intrínseca. En el contexto de embarazo y lactancia, el uso de estos compuestos está estrictamente contraindicado. No existe evidencia clínica suficiente que garantice la seguridad de los alcaloides de Amaryllidaceae en el desarrollo fetal; por el contrario, la capacidad de estos metabolitos para interactuar con procesos celulares fundamentales (como la síntesis de proteínas o la división celular) sugiere un riesgo potencial de teratogenicidad (malformaciones congénitas). Durante la lactancia, existe el riesgo de transferencia de alcaloides a través de la leche materna hacia el lactante, lo que podría provocar efectos neurotóxicos o gastrointestinales impredecibles en el bebé. Para niños menores de 12 años, la seguridad es desconocida y el riesgo es elevado, ya que sus sistemas enzimáticos de desintoxicación hepática no están plenamente desarrollados, lo que aumenta la susceptibilidad a la toxicidad aguda. En cuanto a interacciones farmacológicas, los alcaloides de esta planta pueden interferir con la warfarina (anticoagulante) mediante la alteración de las vías metabólicas del citocromo P450, lo que podría potenciar el efecto anticoagulante y elevar el riesgo de hemorragias.
Otras plantas estudiadas para Toxicidad sistémica por alcaloides
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