Hypericum para Infecciones bacterianas
Hypericum acmosepalum — 13 estudios científicos revisados
Preliminary¿Sirve Hypericum para infecciones bacterianas?
Los metabolitos secundarios pueden interferir con procesos celulares de las bacterias como la síntesis de pared celular.
Compuestos activos involucrados: {'name': 'Acmoxantona A', 'class': 'Xantona lavandulilada'}, {'name': 'Hiperacmosina', 'class': 'Acilflorglucinol policíclico'}, {'name': 'Hiperacmotona A', 'class': 'Acilflorglucinol policíclico'}, {'name': 'Quercetina', 'class': 'Flavonoide'}
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y infecciones bacterianas:
An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis.
In a project to characterise new antibacterial chemotypes from plants, hyperenone A and hypercalin B were isolated from the hexane and chloroform extracts of the aerial parts of Hypericum acmosepalum. The structures of both compounds were characterised by extensive one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and were confirmed by mass spectrometry. Hyperenone A and hypercalin B exhibited antibacterial activity against multidrug-resistant strains of Staphylococcus aureus, with minimum inhibition concentration ranges of 2-128 mg/L and 0.5-128 mg/L, respectively. Hypere
PubMed: 22079533The Phytochemistry and Pharmacology of Hypericum.
Hypericum L. is a genus of the family Hypericaceae within the dicotyledones. The constituents of Hypericum species are valued for their important biological properties. Their use is in the treatment of depression and as antibacterial agents has been well documented in the primary literature and in ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents of members of the genus Hypericum and their biological effects.
PubMed: 33306173Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson.
Hyperacmotone A, a polycyclic polyprenylated acylphloroglucinol (PPAP) with an unprecedented skeleton, along with five undescribed congeners and eleven reported ones, was isolated from Hypericum acmosepalum. Hyperacmotone A possesses a unique monocyclic ring skeleton based on a cyclopent-4-ene-1,3-dione acylphloroglucinol core. Their structures were elucidated by extensive analysis of HRESIMS, NMR, biogenetic pathway, and quantum-chemical calculations. In addition, hypercohone G exhibited significant protective effects on high-glucose-injured HUVECs.
PubMed: 36309111Pharmacokinetic and pharmacodynamic herb-drug interactions-part I. Herbal medicines of the central nervous system.
Unlike conventional drug substances, herbal medicines are composed of a complex of biologically active compounds. Therefore, the potential occurrence of herb-drug interactions is even more probable than for drug-drug interactions. Interactions can occur on both the pharmacokinetic and pharmacodynamic level. Herbal medicines may affect the resulting efficacy of the concomitantly used (synthetic) drugs, mainly on the pharmacokinetic level, by changing their absorption, distribution, metabolism, and excretion. Studies on the pharmacodynamic interactions of herbal medicines and conventional drugs
PubMed: 38025741A review of effective herbal medicines in controlling menopausal symptoms.
BACKGROUND: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. OBJECTIVE: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms. METHODS: This review article was carried out by examining clinical trial studies between the period of 1994 and 2016. The
PubMed: 29403626Contexto Científico
Esto significa que, en un entorno controlado de laboratorio, estas sustancias demostraron capacidad para proteger las células del hígado contra toxinas químicas. Tercero, se ha explorado el potencial antibacteriano de la planta, específicamente contra patógenos resistentes. Los resultados mostraron concentraciones mínimas de inhibición (el nivel más bajo de la sustancia necesario para detener el crecimiento bacteriano) de entre 2-128 mg/L para la hiperenona A y 0.5-128 mg/L para la hipercalina B. En términos simples, la planta contiene sustancias que pueden frenar el crecimiento de bacterias peligrosas, aunque la efectividad varía según la dosis. En el mismo contexto del estudio antibacteriano, se evaluó si los compuestos inhibían la enzima MurE (una proteína esencial para la construcción de la pared celular de la bacteria) en Mycobacterium tuberculosis.
Seguridad y Precauciones
El uso de Hypericum acmosepalum debe abordarse con extrema cautela debido a la complejidad de sus metabolitos secundarios, como los poliprenilados acilfloroglucinoles (PPAPs) y las xantonas, cuya farmacocinética exacta en humanos es aún objeto de investigación. En el contexto de embarazo y lactancia, no existe evidencia clínica suficiente que garantice la seguridad del consumo de esta especie; por lo tanto, su uso está estrictamente contraindicado. Los compuestos bioactivos podrían atravesar la barrera placentaria o excretarse en la leche materna, con riesgos potenciales de interferencia en el desarrollo fetal o neonatal. En niños menores de 12 años, la seguridad no ha sido establecida, y debido a que los sistemas enzimáticos hepáticos infantiles están en desarrollo, el riesgo de toxicidad o de alteraciones metabucionales es significativamente más alto que en adultos. Respecto a las interacciones farmacológicas, el riesgo es crítico. El uso de este tipo de plantas suele inducir enzimas del citocromo P450 en el hígado, lo que puede acelerar el metabolismo de otros fármacos y reducir su eficacia.
Otras plantas estudiadas para Infecciones bacterianas
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