Hypericum para Toxicidad sistémica por acumulación
Hypericum aethiopicum — 4 estudios científicos revisados
Preliminary¿Sirve Hypericum para toxicidad sistémica por acumulación?
La falta de dosis estandarizadas puede llevar a niveles de metabolitos que afectan órganos diana como el hígado o los riñones.
Compuestos activos involucrados: {'name': 'Hipericina', 'class': 'Naftodiantrona'}, {'name': 'Quercetina', 'class': 'Flavonoide'}, {'name': 'Ácido clorogénico', 'class': 'Ácido fenólico'}
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y toxicidad sistémica por acumulación:
Antimicrobial Activity, Phenolic Content, and Cytotoxicity of Medicinal Plant Extracts Used for Treating Dermatological Diseases and Wound Healing in KwaZulu-Natal, South Africa.
Medicinal plants used for wound healing and skin diseases are the key to unlocking the doors to combating problematic skin diseases as resistance of pathogens to pharmaceuticals and allopathic management continues to increase. The study aimed at investigating the antimicrobial efficacies, phenolic content, and cytotoxicity effects of 11 medicinal plant extracts commonly used for treating skin conditions and wound healing in traditional medicine within KwaZulu-Natal. Eleven plant species were separated into different plant parts (bulbs, roots, leaves) and extracted with different solvents. The
PubMed: 27746731The Phytochemistry and Pharmacology of Hypericum.
Hypericum L. is a genus of the family Hypericaceae within the dicotyledones. The constituents of Hypericum species are valued for their important biological properties. Their use is in the treatment of depression and as antibacterial agents has been well documented in the primary literature and in ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents of members of the genus Hypericum and their biological effects.
PubMed: 33306173Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression.
PubMed: 39598400Optimization of Combined Ultrasound and Microwave-Assisted Extraction for Enhanced Bioactive Compounds Recovery from Four Medicinal Plants: Oregano, Rosemary, Hypericum, and Chamomile.
This study presents the synergistic application of ultrasound- and microwave-assisted extraction (UAE-MAE) as a novel and efficient method for recovering bioactive compounds from the medicinal plants oregano, rosemary,
PubMed: 39683930Seguridad y Precauciones
El uso de Hypericum aethiopicum requiere una vigilancia extrema debido a su potencial de interacciones bioquímicas complejas. En el caso de mujeres embarazadas o en periodo de lactancia, el uso de esta planta no se recomienda bajo ninguna circunstancia debido a la falta de estudios de seguridad clínica que garanticen que sus compuestos no atraviesen la barrera placentaria o se secreten en la leche materna. La exposición fetal o neonatal a compuestos bioactivos de plantas con actividad enzimática puede alterar el desarrollo fisiológico del infante. Asimismo, el uso en niños menores de 12 años debe evitarse estrictamente, ya que los sistemas metabólicos y de aclaramiento renal/hepático en etapas de crecimiento son altamente sensibles a la inducción enzimática y a la toxicidad sistémica, lo que podría interferir con procesos hormonales críticos. Respecto a las interacciones farmacológicas, aunque los datos específicos de H. aethiopicum son limitados, se debe extrapolar la precaución observada en especies del género Hypericum.
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