Hypericum para Actividad antiinflamatoria (anti-oedematogénica)
Hypericum grandifolium — 8 estudios científicos revisados
Moderate¿Sirve Hypericum para actividad antiinflamatoria (anti-oedematogénica)?
Los extractos de la planta poseen la capacidad de reducir el edema (hinchazón) en modelos experimentales, posiblemente mediante la inhibición de mediadores inflamatorios.
Compuestos activos involucrados: Flavonoides, Hipericina, Terpenos, Hiperforina
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y actividad antiinflamatoria (anti-oedematogénica):
HPLC-MS analysis and anti-oedematogenic activity of Hypericum grandifolium Choisy (Hypericaceae).
A study has been carried out on the chemical composition and in vivo anti-oedematogenic activity of several extracts from Hypericum grandifolium Choisy (Hypericaceae) collected in Tenerife (Canary Islands). The HPLC-MS analysis (HPLC-ESI/MS and HPLC-FT/MS) revealed the presence of hyperforin, flavonoids and probably benzophenone derivatives, while naphthodianthrones were absent. Pharmacological results revealed that the methanol extracts and the aqueous, butanol and chloroform fractions obtained therefrom possess anti-oedematogenic activity against TPA-induced ear oedema and carrageenan-induce
PubMed: 18484525Hypericum grandifolium Choisy: a species native to Macaronesian Region with antidepressant effect.
AIM OF THE STUDY: Various species of Hypericum genus have been used in the Canary Islands as sedative, diuretic, vermifuge, wound healing, antihysteric and antidepressant agent. Studies have shown that methanol extract of Hypericum grandifolium Choisy is active in tetrabenazine-induced ptosis and forced swimming tests. In the current study, the aqueous, butanol and chloroform fractions obtained from the methanol extract as well as three sub-fractions derived from the chloroform fraction were evaluated for their central nervous effects in mice, particularly their antidepressant activity. MATERI
PubMed: 19041704Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium).
In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Islands where they are traditionally used as diuretic, wound healing, vermifuge, sedative and antidepressive agents. The polar extracts of the top flowering aerial parts, prepared by Soxhlet apparatus using a methanol-acetone (1:1) extracting mixture, were analyzed by HPLC-DAD and HPLC-MS for the content of eight biomarkers such as hypericin, hyperforin, chlorogenic acid, rutin, hyperoside, isoquerc
PubMed: 25464055Bioactive Potential: A Pharmacognostic Definition through the Screening of Four
In this work, we propose a general methodology to assess the bioactive potential (BP) of extracts in the quest of vegetable-based drugs. To exemplify the method, we studied the anticancer potential (AP) of four endemic species of genus
PubMed: 36144833Antinociceptive activity of Hypericum grandifolium Choisy in mice.
The present study investigated the antinociceptive activity of different extracts prepared from the aerial parts of blossom of Hypericum grandifolium Choisy-a species native to the Macaronesian Region-using the acetic acid-induced writhing, formalin and tail flick test in mice. Oral administration of methanol extract (500 and 1,000 mg/kg p.o.), the aqueous, butanol and chloroform fractions (500 mg/kg p.o.) as well as subfractions F2 and F3 (45 mg/kg p.o.) from the chloroform fraction significantly inhibited acetic acid-induced writhing, with values ranging from 28 to 50% of inhibition. The met
PubMed: 20953723Seguridad y Precauciones
El uso de Hypericum grandifolium conlleva riesgos significativos que deben ser evaluados con rigor clínico. En el caso de mujeres embarazadas o en periodo de lactancia, la evidencia científica es insuficiente para garantizar la seguridad fetal o neonatal; debido a que los componentes como la hiperforina y los flavonoides pueden atravesar la barrera placentaria o ser excretados en la leche materna, su uso está estrictamente desaconsejado para prevenir posibles alteraciones en el desarrollo neuropsicológico del infante. Para niños menores de 12 años, el riesgo es aún mayor, ya que su sistema nervioso central está en formación y la interacción de compuestos con efectos antidepresivos y neurofarmacológicos (como la potenciación de la actividad serotoninérgica observada en modelos animales) podría causar efectos impredecibles en el comportamiento o el desarrollo motor. Las interacciones farmacológicas son una de las mayores preocupaciones. El mecanismo de acción de este género suele involucrar la modulación de neurotransmisores; por tanto, el uso concomitante con fármacos como la warfarina (anticoagulante) podría verse alterado por la inducción enzimática, aumentando el riesgo de hemorragias o reduciendo la eficacia del tratamiento. En el caso de la metformina (antidiabético), la interacción podría alterar los niveles de glucosa de forma impredecible.
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