Hypericum para Inducción enzimática (Interacción farmacológica)
Hypericum peplidifolium — 11 estudios científicos revisados
Strong¿Sirve Hypericum para inducción enzimática (interacción farmacológica)?
Los compuestos de la planta activan las enzimas del hígado (citocromo P450), lo que hace que el cuerpo elimine los medicamentos recetados mucho más rápido de lo normal, reduciendo su efecto.
Compuestos activos involucrados:
Evidencia Científica
Los siguientes estudios han investigado la relación entre Hypericum y inducción enzimática (interacción farmacológica):
Herbal medicines in the treatment of psychiatric disorders: 10-year updated review.
This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exi
PubMed: 29575228Ethnobotanical and ethnomedicinal research into medicinal plants in the Mt Stara Planina region (south-eastern Serbia, Western Balkans).
BACKGROUND: Ethnobotanical research in Southeast Europe-one of the most important European hotspots for biocultural diversity-is significant for the acquisition of Traditional Ecological Knowledge related to plants as well as for encouraging the development of local environments. The current ethnobotanical research was conducted in the region of Mt Stara Planina (south-eastern Serbia), which is characterised by rich phytodiversity with a large number of endemic and relict plant species. The aim of the study was to document the diversity of uses of medicinal plants and of traditional knowledge
PubMed: 38200599Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression.
PubMed: 39598400Pharmacokinetic and pharmacodynamic herb-drug interactions-part I. Herbal medicines of the central nervous system.
Unlike conventional drug substances, herbal medicines are composed of a complex of biologically active compounds. Therefore, the potential occurrence of herb-drug interactions is even more probable than for drug-drug interactions. Interactions can occur on both the pharmacokinetic and pharmacodynamic level. Herbal medicines may affect the resulting efficacy of the concomitantly used (synthetic) drugs, mainly on the pharmacokinetic level, by changing their absorption, distribution, metabolism, and excretion. Studies on the pharmacodynamic interactions of herbal medicines and conventional drugs
PubMed: 38025741A review of effective herbal medicines in controlling menopausal symptoms.
BACKGROUND: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. OBJECTIVE: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms. METHODS: This review article was carried out by examining clinical trial studies between the period of 1994 and 2016. The
PubMed: 29403626Seguridad y Precauciones
El uso de especies del género Hypericum, como Hypericum peplidifolium, requiere una vigilancia extrema debido a su compleja química secundaria. En el contexto de embarazo y lactancia, el uso de estas plantas está contraindicado debido a la falta de estudios de seguridad clínica que garanticen la ausencia de efectos teratogénicos (malformaciones fetales) o alteraciones en el desarrollo del lactante. Los compuestos bioactivos, como los fenil policetidos y derivados de floroglucinol identificados en especies de este género [PMID 26880290], pueden atravesar la barrera placentaria o ser excretados en la leche materna, con riesgos potenciales de toxicidad sistémica para el neonato. En niños menores de 12 años, la precaucción debe ser absoluta; el sistema enzimático hepático y el desarrollo neurológico infantil son altamente sensibles a los inductores enzimáticos, lo que podría alterar procesos metabólicos críticos. Uno de los riesgos más severos es la interacción fármaco-planta. Los compuestos de Hypericum actúan como potentes inductores de las enzimas del citocromo P450 (específicamente CYP3A4) y de la glicoproteína P.
Otras plantas estudiadas para Inducción enzimática (Interacción farmacológica)
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